DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and Scyl3

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001178757.1	Gene:	Scyl3 / 360866	RGDID:	1308992	Length:	735	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	203/777 - (26%)
Similarity:	344/777 - (44%)	Gaps:	149/777 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNEGSKLKGILVEENAVETNQFWTVYNAKTPETTNDERCSQMLSVFEGKVFVKAHVWSNGVGPI 65
            ||:|.|.||...:.|..........||    |....|.:|:   |||..|        ......:
  Rat     1 MGSENSALKSYTLGEPPYTLPSGLAVY----PAVLQDGKCA---SVFVYK--------RENEDKV 50

  Fly    66 ERAIKNLMVYRHPYILKYIATWEKSGRKYLATERVRPLDEVLAQQTDIEVCLGLRTILCALIFLV 130
            .:|.|:|...|||.:|::::...::...:|.||||:||:..|...:..|||.|:..||.||:||.
  Rat    51 NKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSPAEVCAGIYDILLALVFLH 115

  Fly   131 EKALARHLNINTQSIYVTESGSWRLAGFEYVWRATDVNKQLL---------------DLAHSFID 180
            |:....|.|:...|::|:|.|.|:|.|.|.|.:.:....:.|               :::..|..
  Rat   116 ERGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSVRDPASIPPEEMSPDFAA 180

  Fly   181 L-TIHGENFEQFFFSILCEKVLS--RKGTDSCITDSTPHVHEFREYCSTHLKHQNTKLRPRLSAI 242
            | ..||...:.:.|..|.:.:|.  .:...:.:..|      |.:...:.|.......||.||.:
  Rat   181 LPESHGHARDAYAFGALVDSLLPIFNEQVSADVLSS------FLQTLHSALLSPTPTCRPALSTL 239

  Fly   243 LLHPYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEEVVASQLACDLLSRMVLLDPA 307
            |.|.:|.::|:.:.:||..|.|||..|:.:||:.|:||:....||::||:|...||:::|..:|.
  Rat   240 LSHDFFRNDFLEVVNFLKSLTLKSEDEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPV 304

  Fly   308 AQEFVTPHILRTKVTDKAPAS---LFSPQIYVQYLMPHILKMFRLRDAQIRLILLDYFMDYVRLL 369
            |.:...|::|..| .:.||..   |.||.::...::|.:|::|.:.:..:|::||.:...||...
  Rat   305 AVKSFLPYLLGPK-KENAPGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHF 368

  Fly   370 SDEQLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGANKVLGGDRARCFS----------- 423
            :.|||:..|||.:.||:.||:|.:|..|||.:|.|||:||...|:||.|::.|.
  Rat   369 TQEQLKKVILPQVLLGLRDTSDSIVAITLRSLAVLVSLLGPEVVVGGQRSKIFKRTAPSFTKTSD 433

  Fly   424 ---DGRP-HAAVSRD----------SNNPYPEPRSISPLMNTRSFDVEDFMVSGSPLPQESNASP 474
               :|.| |...|:.          |:|.:|:..|.:..:|:|....|::.   |.|.|..:...
  Rat   434 LSPEGSPMHVVCSQQSRISKVLENPSSNVFPKWFSGNMSINSRKHIQEEYY---STLLQTGDQFS 495

  Fly   475 LSIRLSPDGGEDEKLRLNSNEKSISI-------------------KH-----NIDPEKDSYISGT 515
            .:|:...:|..|.|   |::|.:.|.                   :|     :|.|::...::.|
  Rat   496 HTIKFPMNGLSDVK---NTSEDNGSFPAGSNKPEEWPDWSEPEEPEHQTTSIHIWPQEPGDVAET 557

  Fly   516 EHERVANIDEEGTWLDWDNTDHLQQGYQVDHA--------VTDSETNSNSF-------AREIQTG 565
            :|..::..:     |.||:.:. ..|.:|:.|        ||..|....:.       ::.:|:.
  Rat   558 QHTSLSAQE-----LSWDDCES-SFGPEVNTAARASAPRPVTSGEQMPTAALLPLTEESKPVQSR 616

  Fly   566 KSLSPSYRTGKCNLSVGVNETISQTEQKVIDDL---SELDIKVQTVIQRSEFNEFDFFKDMEPII 627
            .|...|:|..:   .|...:...:...:|..:|   .|..|:|:.  :.::..|.|:|.||.|.|
  Rat   617 PSSKTSHRQQE---EVKAPQMSQERPPQVRSELGLGEEFTIQVKK--KPAQDPELDWFADMVPEI 676

  Fly   628 ----------EIRT-------STCETPEQISSRFAAAASAVNCNELCADQGWGHDEQDDKDD 672
                      |:||       .|.....|.||:|||......     ..:||..:|...:||
  Rat   677 KPSGTFLILPELRTEGMVPDKDTVSPVMQFSSKFAATEMTEG-----EAEGWEGEELAWEDD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	46/145 (32%)
Scyl3	NP_001178757.1	PKc_like	9..247	CDD:304357	66/258 (26%)
		Pkinase	26..245	CDD:278497	63/239 (26%)
		HEAT repeat	256..283	CDD:293787	11/26 (42%)
		HEAT repeat	294..319	CDD:293787	8/25 (32%)
		HEAT repeat	337..367	CDD:293787	8/29 (28%)
		HEAT repeat	376..402	CDD:293787	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336643
Domainoid	1	1.000	203	1.000	Domainoid score	I2888
eggNOG	1	0.900	-	-		E1_KOG1243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3683
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	1	1.000	-	-		FOG0008108
OrthoInspector	1	1.000	-	-		oto95551
orthoMCL	1	0.900	-	-		OOG6_107909
Panther	1	1.100	-	-	LDO	PTHR12984
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6059
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760