DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1344 and Scyl1

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001011938.1	Gene:	Scyl1 / 293684	RGDID:	1307330	Length:	807	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	139/665 - (20%)
Similarity:	230/665 - (34%)	Gaps:	197/665 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 AIKNLMVYRHPYILKYIATWEKSGRKYLATERVRPLDEVLAQQTDI------EVCLGLRTILCAL 126
            |.|.|...|||.||.||...|.....::.||.|.||...|..:.:.      |:..||..|:.||
  Rat    64 AFKRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTYLKARAEAGGLKEQELSWGLHQIVKAL 128

  Fly   127 IFLVEKALARHLNINTQSIYVTESGSWRLAGFEYVWRAT-----DVNKQLLDLAHSFIDLTIHGE 186
            .|||......|.|:...:::|.::|.|:|.|.:|::.|.     ..||.:.:|
  Rat   129 SFLVNDCNLIHNNVCMAAVFVDKAGEWKLGGLDYMYSAQGNGGGPPNKGIPEL------------ 181

  Fly   187 NFEQFFFSILCEK----VLSRKGTD----SCI-----TDSTPHVHEFR-----------EYCSTH 227
              ||:....|.:.    |..:...|    .|:     ..|.|.....|           .||  .
  Rat   182 --EQYDPPELADSSSRAVKEKWSADMWRLGCLIWEVFNGSLPRATALRNPGKIPKSLVTHYC--E 242

  Fly   228 LKHQNTKLRPRLSAILLH-----PYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRYFDEE 287
            |...|.|:||..:..|.:     .:.::.||..:.||.|:.:|...|:.|||:.|...|..|.|:
  Rat   243 LVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDSFPED 307

  Fly   288 VVASQLACDLLSRMVLLDPAAQEF-------VTPHILRTKVTDKAPASLFSPQIYVQYLMPHILK 345
            ....::...||:        |.||       :||..   ||     ....|.:.|.|.::|.::|
  Rat   308 FCRHKVLPQLLT--------AFEFGNAGAVVLTPLF---KV-----GKFLSAEEYQQKIIPVVVK 356

  Fly   346 MFRLRDAQIRLILLDYFMDYVRLLSDEQLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGA 410
            ||...|..:|:.||.....:::.|.:..:.::|.||:..|..|||..:..:|::.|.
  Rat   357 MFSSTDRAMRVRLLQQMEQFIQYLDEPTVNTQIFPHVTHGFLDTNPAIREQTVKSML-------- 413

  Fly   411 NKVLGGDRARCFSDGRPHAAVSRDSNNPYPEPRSISPLMNTRSFDVEDFMVSGSPLPQESNASPL 475
                                             .::|.::..:.:|| .:...:.|..:.:..|
  Rat   414 ---------------------------------LLAPKLSETNLNVE-LLKHFARLQAKDDQGP- 443

  Fly   476 SIRLSPDGGEDEKLRLNSNEKSISIKHNIDPEKDSYISGTEHERVANIDEEGTWLDWDNTDHLQQ 540
                         :|.|:......|        .||:|.:...||.
  Rat   444 -------------IRCNTTVCLGKI--------GSYLSASTRHRVL------------------- 468

  Fly   541 GYQVDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSVGVN-ETISQTEQKVIDDLSELDIK 604
                          :::|:|  .|....:||...|....:...| .::.....|::..|..|.:.
  Rat   469 --------------TSAFSR--ATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKILPVLCGLTVD 517

  Fly   605 VQTVIQRSEFNEF-DFFKDMEPIIEIRTSTCETPEQISSRFAAAASAVNCNELCADQGWGHDEQD 668
            .:..::...|... .|...:|.:.|..|...|..:.:.     |||:.......|  .|..
  Rat   518 PEKSVRDQAFKTIRSFLSKLESVSEDPTQLAEIEKDVH-----AASSPGTGGAAA--SWAG---- 571

  Fly   669 DKDDIVWGVTNVSTL 683
                  |.||.||:|
  Rat   572 ------WAVTGVSSL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	36/112 (32%)
Scyl1	NP_001011938.1	PK_SCY1_like	29..296	CDD:270913	65/247 (26%)
		HEAT repeat	314..336	CDD:293787	7/32 (22%)
		HEAT 1	350..388		9/37 (24%)
		HEAT repeat	351..372	CDD:293787	8/20 (40%)
		HEAT repeat	384..417	CDD:293787	9/73 (12%)
		HEAT 2	389..427		10/78 (13%)
		HEAT repeat	427..458	CDD:293787	6/53 (11%)
		HEAT repeat	467..499	CDD:293787	8/66 (12%)
		HEAT 3	507..545		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..807
		Interaction with COPB1. /evidence=ECO:0000250	792..807
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820