Protein Alignment CG1344 and scyl-1

DIOPT Version :10

• Sequence 1: NP_610175.2
• Gene: CG1344 / 35500
• FlyBaseID: FBgn0027507
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_001366843.1
• Gene: scyl-1 / 179789
• WormBaseID: WBGene00012337
• Length: 820
• Species: Caenorhabditis elegans
• Alignment Length: 796
• Identity: 163/796 - (20%)
• Similarity: 268/796 - (33%)
• Gaps: 233/796 - (29%)

  Fly    49 GKVFVKAH-------VWSNGVGPIERAIKNLMVYRHPYILKYIATWEKSGRKYLATERVRPLDEV 106
            |..|.||.       .|.|....:::..:.|...|||.|:.|:.:.|..|..||.||:.:||:..
 Worm    35 GNSFKKAEPGELATIFWDNRSSTLKQQAQKLKTMRHPNIITYLDSIELEGTFYLVTEKCKPLELY 99

  Fly   107 LAQ------QTDIEVCLGLRTILCALIFLVEKALARHLNINTQSIYVTESGSWRLAGFEYVWRAT 165
            |.:      |.:..|..|:..:|.||.|:.|..|: |.|:. :.::||..|.|::.|...|...|
 Worm   100 LKEAGLTESQKEFVVSWGMFQLLNALKFMHEAKLS-HENLR-KGVFVTAGGDWKIGGLHLVTGFT 162

  Fly   166 DVNKQLLDLAHSFIDLTIHGENFEQFFFSILCEKVLSRKGTDSCITDSTP-----HVHEFREYCS 225
            .....|..||      .:..|.|..|              .|:......|     .:||.
 Worm   163 SPQTDLNQLA------IVLWEVFNGF--------------NDAITRPQAPGKIPQRIHEL----- 202

  Fly   226 THLKHQNTKLRPRLSAI-------LLHPYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRY 283
              .|....:...||:..       |...|..::||....||.|..||...|:..||..|.:.:..
 Worm   203 --YKKIGAQSAARLAVCDIIKEYRLTGGYLKNKFVDTLLFLEEFELKEASEKQSFFMHLRENIDI 265

  Fly   284 FDEEVVASQLACDLLSRMVL---LDPAAQEFVTPHILRTKVTDKAPASLFSPQIYVQYLMPHILK 345
            |.|:|...:    :|.:::|   ...|....:.|.....::.|:|.        |.:.::|.:.|
 Worm   266 FPEDVAKYK----ILPKLILTYEYGDAGPNILIPLFKLGRLLDEAE--------YQRTIVPCLCK 318

  Fly   346 MFRLRDAQIRLILLDYFMDYVRLLSDEQLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGA 410
            :|...|...|:.||:...::...|:.:.|..:|..:|..|..|||..:...|::.|..|...|..
 Worm   319 LFGSPDRTTRVKLLERIDEFAPHLTPQILNDKIFGNLTSGFLDTNPAVRESTVKAMVSLAEKLNY 383

  Fly   411 N-----------KVLGGDR-------------------ARCFSDGRPHAAVSRDSNNPYPEPR-- 443
            |           ::.|||.                   |.....|...:|.:|...:|:...|
 Worm   384 NNLNVELMKYLARLQGGDEHGGIRTNTTICLGKIGHLIAPAKRQGILISAFTRALKDPFAPSRMA 448

  Fly   444 SISPLMNTRSFDVEDFMVSGSPLPQESN---ASPLSIRLSPD-----------GGEDEKLRLNSN 494
            |:..|..|:.|         .||.:.||   .|.:.:...|:           .|..|||. .::
 Worm   449 SVLALSATQQF---------YPLVEISNRIVPSLIPLTCDPEKQVRDQAFKAIRGFLEKLE-KAS 503

  Fly   495 EKSISIKHNIDPEKDSYI-----SGTEHERVANIDEEGTWLDWDNTDHLQQGYQ----------- 543
            |....|     ||.::.:     |..:||:|..      |..|.......:.|:
 Worm   504 ENPACI-----PELEAGVKAGASSILDHEKVPQ------WASWALKSLSGKFYKGPPPAEVKPGA 557

  Fly   544 ------VDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSVGVNE-TISQTEQKVIDDLSEL 601
                  ....||.:.|.....:..:.......|:...|..:|:.|.:. .:..:....|||.:::
 Worm   558 PATADTSSRPVTPNPTAEKEKSSTVLKPTPAKPATNDGWGDLTDGGDMFAVKDSNDSAIDDWADI 622

  Fly   602 DIKVQTVIQRSEFNEFDFF----------KDMEPIIEIRTSTC---------------------- 634
            :.|         .|:.|.:          ....||..::.|:.
 Worm   623 NTK---------SNDADDWGVGWDTPIATATSSPIPGVKKSSSSSSAAAKKPTIGRLNLGSNLAG 678

  Fly   635 -----ETPEQISSRF---------AAAASAVNCNELCA---------DQGWGHDE---------- 666
                 :|.:.|....         .||.|:|..|.|.|         :.|||.|:
 Worm   679 SSAQKQTKKAIDDNIDALLGISAPPAAGSSVKPNSLNALMNNSSSSTNTGWGFDDPLPTTNNSSA 743

  Fly   667 QDDKDDIVWGVTNVST 682
            ....||..||..::|:
 Worm   744 NKGWDDDGWGDNSMSS 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_610175.2	Protein Kinases, catalytic domain	24..>170	CDD:473864	39/133 (29%)
scyl-1	NP_001366843.1	Protein Kinases, catalytic domain	58..>165	CDD:473864	33/108 (31%)
		HEAT repeat	313..337	CDD:293787	7/23 (30%)
		HEAT repeat	346..379	CDD:293787	10/32 (31%)
		HEAT	361..492	CDD:441023	27/139 (19%)
		HEAT repeat	389..420	CDD:293787	3/30 (10%)
		HEAT repeat	429..455	CDD:293787	6/25 (24%)
		HEAT repeat	466..492	CDD:293787	4/25 (16%)
		HEAT repeat	507..539	CDD:293787	9/42 (21%)