DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1344 and scyl-1

DIOPT Version :9

Sequence 1:	NP_001260711.1	Gene:	CG1344 / 35500	FlyBaseID:	FBgn0027507	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001366843.1	Gene:	scyl-1 / 179789	WormBaseID:	WBGene00012337	Length:	820	Species:	Caenorhabditis elegans

Alignment Length:	796	Identity:	163/796 - (20%)
Similarity:	268/796 - (33%)	Gaps:	233/796 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GKVFVKAH-------VWSNGVGPIERAIKNLMVYRHPYILKYIATWEKSGRKYLATERVRPLDEV 106
            |..|.||.       .|.|....:::..:.|...|||.|:.|:.:.|..|..||.||:.:||:..
Worm    35 GNSFKKAEPGELATIFWDNRSSTLKQQAQKLKTMRHPNIITYLDSIELEGTFYLVTEKCKPLELY 99

  Fly   107 LAQ------QTDIEVCLGLRTILCALIFLVEKALARHLNINTQSIYVTESGSWRLAGFEYVWRAT 165
            |.:      |.:..|..|:..:|.||.|:.|..|: |.|:. :.::||..|.|::.|...|...|
Worm   100 LKEAGLTESQKEFVVSWGMFQLLNALKFMHEAKLS-HENLR-KGVFVTAGGDWKIGGLHLVTGFT 162

  Fly   166 DVNKQLLDLAHSFIDLTIHGENFEQFFFSILCEKVLSRKGTDSCITDSTP-----HVHEFREYCS 225
            .....|..||      .:..|.|..|              .|:......|     .:||.
Worm   163 SPQTDLNQLA------IVLWEVFNGF--------------NDAITRPQAPGKIPQRIHEL----- 202

  Fly   226 THLKHQNTKLRPRLSAI-------LLHPYFNHEFVLIHSFLFELPLKSVHERHKFFRSLIDRLRY 283
              .|....:...||:..       |...|..::||....||.|..||...|:..||..|.:.:..
Worm   203 --YKKIGAQSAARLAVCDIIKEYRLTGGYLKNKFVDTLLFLEEFELKEASEKQSFFMHLRENIDI 265

  Fly   284 FDEEVVASQLACDLLSRMVL---LDPAAQEFVTPHILRTKVTDKAPASLFSPQIYVQYLMPHILK 345
            |.|:|...:    :|.:::|   ...|....:.|.....::.|:|.        |.:.::|.:.|
Worm   266 FPEDVAKYK----ILPKLILTYEYGDAGPNILIPLFKLGRLLDEAE--------YQRTIVPCLCK 318

  Fly   346 MFRLRDAQIRLILLDYFMDYVRLLSDEQLESEILPHLQLGMNDTNDVLVGKTLRCMADLVSILGA 410
            :|...|...|:.||:...::...|:.:.|..:|..:|..|..|||..:...|::.|..|...|..
Worm   319 LFGSPDRTTRVKLLERIDEFAPHLTPQILNDKIFGNLTSGFLDTNPAVRESTVKAMVSLAEKLNY 383

  Fly   411 N-----------KVLGGDR-------------------ARCFSDGRPHAAVSRDSNNPYPEPR-- 443
            |           ::.|||.                   |.....|...:|.:|...:|:...|
Worm   384 NNLNVELMKYLARLQGGDEHGGIRTNTTICLGKIGHLIAPAKRQGILISAFTRALKDPFAPSRMA 448

  Fly   444 SISPLMNTRSFDVEDFMVSGSPLPQESN---ASPLSIRLSPD-----------GGEDEKLRLNSN 494
            |:..|..|:.|         .||.:.||   .|.:.:...|:           .|..|||. .::
Worm   449 SVLALSATQQF---------YPLVEISNRIVPSLIPLTCDPEKQVRDQAFKAIRGFLEKLE-KAS 503

  Fly   495 EKSISIKHNIDPEKDSYI-----SGTEHERVANIDEEGTWLDWDNTDHLQQGYQ----------- 543
            |....|     ||.::.:     |..:||:|..      |..|.......:.|:
Worm   504 ENPACI-----PELEAGVKAGASSILDHEKVPQ------WASWALKSLSGKFYKGPPPAEVKPGA 557

  Fly   544 ------VDHAVTDSETNSNSFAREIQTGKSLSPSYRTGKCNLSVGVNE-TISQTEQKVIDDLSEL 601
                  ....||.:.|.....:..:.......|:...|..:|:.|.:. .:..:....|||.:::
Worm   558 PATADTSSRPVTPNPTAEKEKSSTVLKPTPAKPATNDGWGDLTDGGDMFAVKDSNDSAIDDWADI 622

  Fly   602 DIKVQTVIQRSEFNEFDFF----------KDMEPIIEIRTSTC---------------------- 634
            :.|         .|:.|.:          ....||..::.|:.
Worm   623 NTK---------SNDADDWGVGWDTPIATATSSPIPGVKKSSSSSSAAAKKPTIGRLNLGSNLAG 678

  Fly   635 -----ETPEQISSRF---------AAAASAVNCNELCA---------DQGWGHDE---------- 666
                 :|.:.|....         .||.|:|..|.|.|         :.|||.|:
Worm   679 SSAQKQTKKAIDDNIDALLGISAPPAAGSSVKPNSLNALMNNSSSSTNTGWGFDDPLPTTNNSSA 743

  Fly   667 QDDKDDIVWGVTNVST 682
            ....||..||..::|:
Worm   744 NKGWDDDGWGDNSMSS 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1344	NP_001260711.1	PKc_like	24..>170	CDD:304357	39/133 (29%)
scyl-1	NP_001366843.1	PKc_like	58..>165	CDD:419665	33/108 (31%)
		HEAT repeat	313..337	CDD:293787	7/23 (30%)
		HEAT repeat	346..379	CDD:293787	10/32 (31%)
		HEAT repeat	389..420	CDD:293787	3/30 (10%)
		HEAT repeat	429..455	CDD:293787	6/25 (24%)
		HEAT_EZ	446..492	CDD:404407	11/54 (20%)
		HEAT repeat	466..492	CDD:293787	4/25 (16%)
		HEAT repeat	507..539	CDD:293787	9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1074965at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820