Protein Alignment hrm and SLC16A7

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: XP_011537291.1
• Gene: SLC16A7 / 9194
• HGNCID: 10928
• Length: 504
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 147/640 - (22%)
• Similarity: 240/640 - (37%)
• Gaps: 225/640 - (35%)

  Fly    49 PPDGGWGWLVLLGSCLTNI----LIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPAL--------- 100
            ||||||||:| :|:...:|    ..|   |:..|.|.|....|:::.::.|||.::
Human    13 PPDGGWGWIV-VGAAFISIGFSYAFP---KAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGG 73

  Fly   101 ---------------CYFLYSS--LGPVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFL 148
                           |.|..|.  ||||||:|..||..|.|.:.||....|||:|:.::||:..|
Human    74 RIFESFLIFTSLRIQCSFTQSGSCLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQL 138

  Fly   149 YISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGS 213
            |::.|.:.|:|...:..|.:.|:..||.:.|.:||||.::||.:....|.|..::|..|:|:.||
Human   139 YLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGS 203

  Fly   214 CLIMGGITLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADK 278
            .||:|.:.||..||                              |.:|                :
Human   204 FLILGSLLLNACVA------------------------------GSLM----------------R 222

  Fly   279 PLLPYNSPPSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQ 343
            ||.|.                          |:.|||                   :|:|
Human   223 PLGPN--------------------------QTTSKS-------------------KNKT----- 237

  Fly   344 LNSQSSLYAVPEGRSSSNKLTLRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSL 408
                    ...|..||..|:..:.|:..::
Human   238 --------GKTEDDSSPKKIKTKKSTWEKV----------------------------------- 259

  Fly   409 RSMGSSGTGHAGDSTGQDGSYADVDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTN 473
                                               :|:.|.||.|...:|:.|   |.|.|.:..
Human   260 -----------------------------------NKYLDFSLFKHRGFLIYL---SGNVIMFLG 286

  Fly   474 F---IILLPSFGEARGFNKSLSAYLLSVVSATDLIGRIGGSALSDMGYI-PKTWYFVG-GLSISG 533
            |   ||.|..:.:.:|.::..:|:||||::..|:..|.....:::..|| |:..||.. .:..:|
Human   287 FFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNG 351

  Fly   534 LSLALLPFAWTYSSVCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGP 598
            :...|.|.|..|:|:..:...|||..|....:....:.|::|..|.:|:.|:...|.....|:||
Human   352 VCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGP 416

  Fly   599 PLCNYWFEAVNDYNPLFHALGLTLLAGASLWSFM-PWIN-------RRKANAEEQ 645
            ||.....:...:|..::.:.|..::| ||:|..: ..||       |::.||.::
Human   417 PLAGKLVDLTGEYKYMYMSCGAIVVA-ASVWLLIGNAINYRLLAKERKEENARQK 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	66/205 (32%)
		MFS	<451..633	CDD:475125	51/187 (27%)
SLC16A7	XP_011537291.1	2A0113	15..484	CDD:273325	145/638 (23%)