Protein Alignment hrm and SLC16A5

DIOPT Version :9

• Sequence 1: NP_001286141.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: XP_005257847.1
• Gene: SLC16A5 / 9121
• HGNCID: 10926
• Length: 545
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 126/623 - (20%)
• Similarity: 217/623 - (34%)
• Gaps: 204/623 - (32%)

  Fly    51 DGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSIL 115
            ||.|.|:|||.:.:|..|..|.....|:.|:|....|.:|.::.:|.|::...:....||:.|||
Human    49 DGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSIL 113

  Fly   116 SVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRG 180
            ..::..|...:|||..|||||:.|.::.::..||.:.|.:.|:|...||..::.::..||.:.|.
Human   114 VGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRV 178

  Fly   181 LANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRAR 245
            |||.|...|.:||..:.|.|.|:|||..|:.|:.|:.|||.|:..:......||
Human   179 LANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPV----------- 232

  Fly   246 QALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQ 310
             |....||.::                            .||.|
Human   233 -ATSVAPETKE----------------------------CPPPP--------------------- 247

  Fly   311 SYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRLSK 375
                                                       ||
Human   248 -------------------------------------------PE-------------------- 249

  Fly   376 RSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQAQQ 440
                        ||                 :|..:.:.|                       :.
Human   250 ------------TP-----------------ALGCLAACG-----------------------RT 262

  Fly   441 PQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSVVSATDLI 505
            .||...||: |..:..|.|.::....:.:.:....:.|..:......::..:|.|:|::..:::.
Human   263 IQRHLAFDI-LRHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIF 326

  Fly   506 GR-IGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAWTYSSVC-----FW-----CALFGLA- 558
            .| :.|.......:.....|.        .|||||....| :.||     ||     |..:.::
Human   327 LRPLAGLMAGRPAFASHRKYL--------FSLALLLNGLT-NLVCAASGDFWVLVGYCLAYSVSM 382

  Fly   559 SGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFH-----AL 618
            |||...|..|:| |::..::...:.|:...::||..|:.|||.....:|.|:::.:|:     .:
Human   383 SGIGALIFQVLM-DIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLI 446

  Fly   619 GLTLLAGASLWSFMPWINRRKANAEEQLDAQIEKAAVD 656
            ...|..|.|.::.......::|.|.:.|:..:...|.|
Human   447 SAALFMGGSFYALQKKEQGKQAVAADALERDLFLEAKD 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	124/618 (20%)
		MFS	59..>234	CDD:119392	57/174 (33%)
		MFS	<449..633	CDD:119392	41/200 (21%)
SLC16A5	XP_005257847.1	2A0113	41..493	CDD:273325	126/623 (20%)
		MFS	54..452	CDD:119392	116/584 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D518644at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm9818
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920