Protein Alignment hrm and ESBP6

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_014274.1
• Gene: ESBP6 / 855598
• SGDID: S000005069
• Length: 673
• Species: Saccharomyces cerevisiae
• Alignment Length: 662
• Identity: 122/662 - (18%)
• Similarity: 207/662 - (31%)
• Gaps: 231/662 - (34%)

  Fly    12 ASKINQKDHKPNGNTN-ESRHKTV-SLINKKDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIK 74
            ::|.:.||.:..|.|. |....|| .:...|...:.:| |||||:||:|.....||.....|...
Yeast   168 STKHSGKDLEAQGITEFEPDEPTVKKVFTNKSTGQLEL-PPDGGYGWVVTFCVFLTMFSTWGCNA 231

  Fly    75 SFGVLFSEFT--DAF-NSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGM 136
            ||||..:.:.  |.: .:|....|.|..|..||...|.|:...|......||..|.|.|......
Yeast   232 SFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAY 296

  Fly   137 ILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLL 201
            :|:.:.:.:..||::.|.:||....|.|.|...::..:|.|.|.:|.|:.:.|:..|.::.....
Yeast   297 LLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLAT 361

  Fly   202 RWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENV 266
            ..:|..:|....||.:.||:.::.|.                             :.|.:
Yeast   362 NKMLSDFGNTRWCLRIIGISCSISVL-----------------------------VAIAL----- 392

  Fly   267 DEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKISTPVR 331
                                                                             
Yeast   393 ----------------------------------------------------------------- 392

  Fly   332 LPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLS 396
            |.:||.|                                ..:..:||
Yeast   393 LKERNPT--------------------------------PAIGLKSP------------------ 407

  Fly   397 FQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQAQQPQRSKFFDLSLLKDPMYLVIL 461
                                                    :|...|....|.|.::..|..::|.
Yeast   408 ----------------------------------------RAMFEQLKAMFSLKVITKPFVVLIA 432

  Fly   462 ISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSVVSATDLIGR-IGGSALSDMGYIPKTWYF 525
            :.......:|...:..|.|:..::|.:...::.|.::::.:..||| :.|.|....|....|
Yeast   433 LWFMFALFAYNMMVFTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRANVT--- 494

  Fly   526 VGGLSISGLSLALLPFA-W----TYSSVCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGI 585
               :.::.| |.:..|| |    |:..:.|:..|.|...|:...:..|::|||:..|....::.
Yeast   495 ---IVLTTL-LTIYMFAFWIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWA- 554

  Fly   586 SLFVNGLLQLVGPP---LCNYWFEAV----NDYNPLFHA---LGLTLLAGASL------WSFMPW 634
              |||    ..|.|   :|....:|:    :..||..||   .|...:|...|      :|....
Yeast   555 --FVN----YCGAPFLLVCEVIAQALTVEKDKSNPYLHAQIFCGCCFIAALILISILREYSIRMK 613

  Fly   635 INRRKANAEEQL 646
            :..|:|...|:|
Yeast   614 LTERQAMTNEKL 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	48/178 (27%)
		MFS	<451..633	CDD:475125	44/203 (22%)
ESBP6	NP_014274.1	MFS_MCT_SLC16	212..606	CDD:340910	102/596 (17%)