Protein Alignment hrm and MCH5

DIOPT Version :9

• Sequence 1: NP_001286141.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_014951.4
• Gene: MCH5 / 854483
• SGDID: S000005833
• Length: 521
• Species: Saccharomyces cerevisiae
• Alignment Length: 651
• Identity: 117/651 - (17%)
• Similarity: 204/651 - (31%)
• Gaps: 233/651 - (35%)

  Fly     5 KIINSQNASKINQKDHKPN-GNTNESRHKTVSLINKKDDKEYDLVP-PDGGW-GWLVLLGSCLTN 66
            |:...:..:|....:.:|: |....|.|.:    :|::|...::.. |:||: .|:|..|..|..
Yeast    57 KVYTKKEVNKGTDIESQPHWGENTSSTHDS----DKEEDSNEEIESFPEGGFKAWVVTFGCFLGL 117

  Fly    67 ILIPGTIKSFGVLFSEFTD--AFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKY----SYRTVT 125
            |...|.:.|.||:.|...|  ..:.|.:...|:.:|..|:.|:    |.|:|..|    .:||:.
Yeast   118 IACFGLLNSTGVIESHLQDNQLSSESVSTIGWLFSLFLFVCSA----SCIISGTYFDRNGFRTIM 178

  Fly   126 LLGGASASLGMILSFWASSIEFLY--ISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCIS 188
            ::|......|:..:  |:|.::.:  :|:.::.|.|.|:...|.|.:...||.|.||.|..:...
Yeast   179 IVGTVFHVAGLFAT--ANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATI 241

  Fly   189 GSALGSIILPPLLRWLLE-------TYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRARQ 246
            |.::|.::.|.:||....       |||:     :.|..||.....||.
Yeast   242 GGSVGGVVFPIMLRSFFSMKSDTDPTYGF-----VWGIRTLGFLDLALL---------------- 285

  Fly   247 ALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQS 311
                     .:.|::.               |..||:                        |:::
Yeast   286 ---------TLSIILV---------------KERLPH------------------------VIEN 302

  Fly   312 YSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRLSKR 376
             ||.|   :||.|.|                                      ||
Yeast   303 -SKDG---ESRWRYI--------------------------------------LR---------- 315

  Fly   377 SPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQAQQP 441
                   :|:
Yeast   316 -------VYI------------------------------------------------------- 318

  Fly   442 QRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSVVSATDLIG 506
              .:.||.....|..||..::....:.:|..:.:....|:..:.|.:.:.:..|:.:::...:.|
Yeast   319 --LQCFDAKAFLDMKYLFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPG 381

  Fly   507 RIGGSALSDMGYIPKTWYFVGGLSISGLSL---------ALLPFAWTYSSVCFWCALFGLASGIY 562
            |.....|||.         .|..:::..:|         ..|||....:::....||:|..||..
Yeast   382 RWVPGYLSDK---------FGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSV 437

  Fly   563 VGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCN--YWFEAVNDYNPLFHALGLTLLAG 625
            ..:..|....:..||.....|....||.|...|||.|:..  ...:...||.......||.....
Yeast   438 FSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYIIFCGLATFVS 502

  Fly   626 A 626
            |
Yeast   503 A 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	109/606 (18%)
		MFS	59..>234	CDD:119392	49/189 (26%)
		MFS	<449..633	CDD:119392	38/189 (20%)
MCH5	NP_014951.4	MFS_MCT_SLC16	106..510	CDD:340910	106/598 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I1261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920