Protein Alignment hrm and Slc16a3

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_109621.1
• Gene: Slc16a3 / 80879
• MGIID: 1933438
• Length: 470
• Species: Mus musculus
• Alignment Length: 649
• Identity: 127/649 - (19%)
• Similarity: 211/649 - (32%)
• Gaps: 242/649 - (37%)

  Fly    41 DDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLY 105
            |:....:..|||||||.||.|..:.........|:..|.|.|....|....:..|||.::...:.
Mouse     7 DEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSVFFKELMHEFGIGYSDTAWISSILLAML 71

  Fly   106 SSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYI 170
            ...||:.|:...::..|.|.|:||..|||||:.:.:..||..:|::.||:.|:|..|:|.|::.:
Mouse    72 YGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQPSLIM 136

  Fly   171 VTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVE 235
            :..||.|.|.:||||..:||.:....|.||.:.|.:.||:.|..||:||:.||..|.|....|:
Mouse   137 LNRYFNKRRPIANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPL- 200

  Fly   236 QHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQF 300
                                                                             
Mouse   201 ----------------------------------------------------------------- 200

  Fly   301 VRSASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTL 365
                                                                             
Mouse   201 ----------------------------------------------------------------- 200

  Fly   366 RNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYA 430
                                |:....|.|
Mouse   201 --------------------VAPQVGGGT------------------------------------ 209

  Fly   431 DVDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYL 495
              :.||..:.|||  ..|||:.:|..:|:..::.|...:......:.:.|:.:..|...:.:|:|
Mouse   210 --EPRGPQRPPQR--LLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFL 270

  Fly   496 LSVVSATDLIGRIGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAW--------------TYS 546
            |:::...|:..|            |...:..|...:...|:.|..||.              .|.
Mouse   271 LTILGFIDIFAR------------PTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTATDYG 323

  Fly   547 SVCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDY 611
            .:..:|..||::.|:...:...::..::||::.:|:.|:.|.:..:..|:|||......:|...|
Mouse   324 GLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVY 388

  Fly   612 NPLFHALGLTLLAGAS---------LWSFMPWINRRK---------ANAEEQLDAQIEKAAVDS 657
            ..:|      :||||.         |.:|. .|.:||         ..:||:|........|||
Mouse   389 KYVF------ILAGAEVLTSSLVLLLGNFF-CIGKRKRPEVTEPEEVASEEKLHKPPVDVGVDS 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	61/175 (35%)
		MFS	<451..633	CDD:475125	39/204 (19%)
Slc16a3	NP_109621.1	MFS_MCT3_4	21..410	CDD:340988	111/597 (19%)
		Basolateral sorting signal. /evidence=ECO:0000250|UniProtKB:O15427	429..446		6/17 (35%)
		Basolateral sorting signal. /evidence=ECO:0000250|UniProtKB:O15427	446..470		127/649 (20%)