Protein Alignment hrm and SLC16A2

DIOPT Version :9

• Sequence 1: NP_001286141.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_006508.2
• Gene: SLC16A2 / 6567
• HGNCID: 10923
• Length: 539
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 119/612 - (19%)
• Similarity: 207/612 - (33%)
• Gaps: 197/612 - (32%)

  Fly    49 PPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFS----EFTDAFNSSPTKAAWIPALCYFLYSSLG 109
            ||:||:||:|:..:...|..|.|...|.|:|:|    |..:.......:|||:.||...:.....
Human    94 PPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCS 158

  Fly   110 PVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSY 174
            |:.||.:.:...|.....|.|.|.:|:..|.:.||:...|.:||:|.|.|...:|.|::.|:..|
Human   159 PIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHY 223

  Fly   175 FAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMV 239
            |.:..|||||:..:||::.|:..|.|:|.|.:......:..::......:.:.:|.|
Human   224 FQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTY-------- 280

  Fly   240 RVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSA 304
                                                  :||||
Human   281 --------------------------------------RPLLP---------------------- 285

  Fly   305 SAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSS 369
                                                                           ||
Human   286 ---------------------------------------------------------------SS 287

  Fly   370 KSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDA 434
            :...|||...|         .|...|:
Human   288 QDTPSKRGVRT---------LHQRFLA-------------------------------------- 305

  Fly   435 RGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSV- 498
                   |..|:|::.:.:...|.:.....:..|:.|....:.|..:.|.. |::....::|.|
Human   306 -------QLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEE-FSEIKETWVLLVC 362

  Fly   499 VSATDLIGRIGGSALSDMGYIP---KTWYFVGGLSISGLSLALLPFAWTYSSVCFWCALFGLASG 560
            :.||..:||:....:||.  ||   |.:..|....:.||...::|....:..:...|...||..|
Human   363 IGATSGLGRLVSGHISDS--IPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDG 425

  Fly   561 IYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLTLLAG 625
            .::.|.|.|..:::|..:.:.:.|..|.:..|..:.|||:.........||:..|:..|:..:.|
Human   426 FFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIG 490

  Fly   626 ASLWSFMPWINRRKANAEEQLDAQIEK 652
            |.:..|:|.:::|... :||.|:..:|
Human   491 AVILFFVPLMHQRMFK-KEQRDSSKDK 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	119/612 (19%)
		MFS	59..>234	CDD:119392	49/178 (28%)
		MFS	<449..633	CDD:119392	42/187 (22%)
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..92
		2A0113	86..513	CDD:273325	118/607 (19%)
		MFS	101..498	CDD:119392	108/584 (18%)
		DUF1564	<286..>334	CDD:284922	13/101 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..539		4/9 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820