Protein Alignment hrm and SLC16A1

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_003042.3
• Gene: SLC16A1 / 6566
• HGNCID: 10922
• Length: 500
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 145/636 - (22%)
• Similarity: 247/636 - (38%)
• Gaps: 207/636 - (32%)

  Fly    49 PPDGGWGWLVLLGSCLT---NILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGP 110
            ||||||||.|::|:.::   :...|   ||..|.|.|....|:::.::.:||.::...:....||
Human    13 PPDGGWGWAVVIGAFISIGFSYAFP---KSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGP 74

  Fly   111 VSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYF 175
            :||||..||..|.|.::||..:..|:|.:.:.::::.||:..||:.|:|...:..|.:.::..||
Human    75 ISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYF 139

  Fly   176 AKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVR 240
            .|.|.|||||.::||.:....|.||.:.....:|:.||.||:||:.||..||.....|:
Human   140 YKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI------ 198

  Fly   241 VPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSAS 305
                                                         .|.|
Human   199 ---------------------------------------------GPKP---------------- 202

  Fly   306 AAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSK 370
                   :|:|                                                 ::.||
Human   203 -------TKAG-------------------------------------------------KDKSK 211

  Fly   371 SRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDAR 435
            :                                   ||...|.||       ..:|...|:.|..
Human   212 A-----------------------------------SLEKAGKSG-------VKKDLHDANTDLI 234

  Fly   436 GQ-AQQPQRS------KFFDLSLLKDPMYLVILISNSTNAISYTNF---IILLPSFGEARGFNKS 490
            |: .:|.:||      :|.||:|.....:|:.|   |.|.|.:...   ::.|.|:|:::.::..
Human   235 GRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYL---SGNVIMFFGLFAPLVFLSSYGKSQHYSSE 296

  Fly   491 LSAYLLSVVSATDLIGRIGGSALSDMGYIPKT--------WYFVGGLSISGLSLALLPFAWTYSS 547
            .||:|||:::..|::.|      ..||.:..|        ::|...:..:|:...|.|.:.||..
Human   297 KSAFLLSILAFVDMVAR------PSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVG 355

  Fly   548 VCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYN 612
            .|.:...||.|.|....:....:.|::|.:|.:|:.|:...|.....|:||||.....:...||.
Human   356 FCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK 420

  Fly   613 PLFHALGLTL-LAGASLWSFMPWINRR------KANAEEQLDAQIEKAAVD 656
            ..:.|.|:.| ::|..|:..| .||.|      ||| |::.:::.|:.::|
Human   421 YTYWACGVVLIISGIYLFIGM-GINYRLLAKEQKAN-EQKKESKEEETSID 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	59/178 (33%)
		MFS	<451..633	CDD:475125	48/193 (25%)
SLC16A1	NP_003042.3	2A0113	1..455	CDD:273325	140/619 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..500		5/17 (29%)