Protein Alignment hrm and slc16a4

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_001074068.2
• Gene: slc16a4 / 567144
• ZFINID: ZDB-GENE-070112-602
• Length: 558
• Species: Danio rerio
• Alignment Length: 643
• Identity: 158/643 - (24%)
• Similarity: 278/643 - (43%)
• Gaps: 124/643 - (19%)

  Fly    18 KDHKPNGNT-----NESRHKTVSLINKKDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSFG 77
            |:...:|.|     :|.:.|   ::.|:..|.....||||||||:|:|...|.|:|:.||:|:||
Zfish     4 KEQHSDGKTAKTPCSELKAK---VMKKEKKKVVYREPPDGGWGWMVVLHCFLVNVLVMGTLKTFG 65

  Fly    78 VLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWA 142
            :.|....|.|..|....:||.::...|..|.||::|:...|...|..:::|....|.|.:.|.:|
Zfish    66 IFFVALQDEFGGSSESISWIGSIMSSLRLSGGPLASVACAKLGNRVTSIVGALFVSAGFLFSIFA 130

  Fly   143 SSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALG-SIILPPLLRWLLE 206
            :|:.:||||.|::||:|..|.:..|..::.:||.|  .||....|..|.:| :..|.|..:.||:
Zfish   131 TSVTYLYISMGLVVGLGFALLYQATSVVIVTYFRK--RLATAYSIGRSGMGLTFALAPFTQLLLD 193

  Fly   207 TYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVP 271
            .|.:.|:.||:||:.||:..:.:...|:.   :|.|.:..:...|.:.|           .:|:.
Zfish   194 QYAWQGALLILGGLMLNLVASGMLLRPIN---IRHPASPISNSTIHKTE-----------KDPLK 244

  Fly   272 KNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRN 336
            .|...:.|                            |....|||..         |.|:   .::
Zfish   245 NNMNGNTP----------------------------VANGTSKSDS---------SPPI---HKD 269

  Fly   337 QTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKE 401
            .......::.|:||..:...:.:.|.:   |.:.|..:|.||..:....|
Zfish   270 TLIIKNPVHEQNSLPHLDLKKPTQNGV---NGTDSSQTKTSPEMNGVSPV--------------- 316

  Fly   402 FSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQAQQPQRS-KFFDLSLLKDPMYLVILISNS 465
                               ||..::|...:|        |:.| |..|.||||:|.:.:.
Zfish   317 -------------------DSLLENGRTENV--------PENSPKVLDFSLLKNPFFCIY----- 349

  Fly   466 TNAISYTNFIILLPSF---GEAR--GFNKSLSAYLLSVVSATDLIGRIGGSALSDMGYIPKTWYF 525
            |.::.::.....:|.|   ..||  |.:...:::::||...|:.:.::....::|...:.|..|.
Zfish   350 TWSLVFSQLAYFIPYFHLSARARNLGIDPMDASFIISVAGITETVAQLASGWVTDRNLVHKYHYH 414

  Fly   526 VGGLSISGLSLALLPFAWTYSSVCFWCALFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVN 590
            ...|.:.|:...|.|.|.:|..:..:...|.:..|.|:.:...::.|::|.::|.:|.|.|:|..
Zfish   415 KAYLILCGVVNLLSPLATSYILLMVYAVFFAIFCGGYMALLLPVLVDLVGADKLNNSMGFSMFFV 479

  Fly   591 GLLQLVGPPLCNYWFEAVNDYNPLFHALGLT-LLAGASLWSFMPWINRRKANAEEQLD 647
            ||..|.||||..:.::....|:..|:..|:. ||:..||  |:..:.||....:|:|:
Zfish   480 GLGCLTGPPLAGFLYDYTQTYDCSFYLAGVCYLLSSISL--FLEPLARRWQARKERLE 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	61/176 (35%)
		MFS	<451..633	CDD:475125	47/187 (25%)
slc16a4	NP_001074068.2	MFS_MCT5	43..526	CDD:340979	141/590 (24%)