Protein Alignment hrm and slc16a1

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_001015931.1
• Gene: slc16a1 / 548685
• XenbaseID: XB-GENE-1014566
• Length: 490
• Species: Xenopus tropicalis
• Alignment Length: 612
• Identity: 131/612 - (21%)
• Similarity: 236/612 - (38%)
• Gaps: 174/612 - (28%)

  Fly    49 PPDGGWGWLVLLGSCLT---NILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGP 110
            ||:|||||:|::.:.::   :...|   ||..|.|.:....|.::.::.:||.::...:..:.||
 Frog    13 PPEGGWGWVVVVAAFVSIGFSYAFP---KSITVFFKDIEAIFGATSSEVSWISSIMLAVMYAGGP 74

  Fly   111 VSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYF 175
            :||:|..||..|.|.:.||..|..|:|.:.:.:::..||:..||:.|.|...:..|.:.::..||
 Frog    75 ISSVLVNKYGSRPVMIAGGCLAGTGLIAASFCNTVAELYLCIGVVGGFGLAFNLNPALTMIGKYF 139

  Fly   176 AKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVR 240
            .|.|.:||||.::||.:....|.||.::....:|:.||.||:||:..|..||.....|:.
 Frog   140 FKKRPIANGLAMAGSPVFLSTLAPLNQYFYSIFGWRGSFLILGGLLFNCCVAGSLMRPIG----- 199

  Fly   241 VPRARQALENIPEE--EDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRS 303
             |:.....:.:.:|  |:.|..:..|:.|        |.|.|:
 Frog   200 -PKPEDTKKKVTKEVLEEAGKCVSKEDGD--------AHKDLI---------------------- 233

  Fly   304 ASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNS 368
                                                               ||::.: |.||
 Frog   234 ---------------------------------------------------EGKAKT-KPTL--- 243

  Fly   369 SKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVD 433
                                        ||
 Frog   244 ----------------------------FQ----------------------------------- 245

  Fly   434 ARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSV 498
                    ..:||.||||.....:|:.|..:..........::.|.::.:::..:...:|:|||:
 Frog   246 --------TINKFLDLSLFTHRGFLLYLSGHMIMFFGLFAPLVFLSNYAKSKNISPESAAFLLSI 302

  Fly   499 VSATDLIGRIGGSALSDMGYI-PKTWYFVG-GLSISGLSLALLPFAWTYSSVCFWCALFGLASGI 561
            ::..|:|.|.....:::..:: ||..||.. .:..:|:...|:|.:.:|...|.:...||.|.|.
 Frog   303 LAIVDMIARPSMGIVANTKWVRPKIQYFFAVAVLYNGICHLLVPLSTSYVGFCIYAGFFGFAFGW 367

  Fly   562 YVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLTLLAGA 626
            ...:....:.|::|.:|.:|:.|:...|.....|:||||.....:...||...:.|.|:.|:. |
 Frog   368 LSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYQACGIVLIV-A 431

  Fly   627 SLWSFMPWINRRKANAEEQLDAQIEKA 653
            |::.|:......:..|:|| .|:.:||
 Frog   432 SVYLFIGMTIHYRLLAKEQ-KAEQKKA 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	55/178 (31%)
		MFS	<451..633	CDD:475125	43/183 (23%)
slc16a1	NP_001015931.1	2A0113	6..471	CDD:273325	131/612 (21%)