Protein Alignment hrm and slc16a12b

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_001139286.1
• Gene: slc16a12b / 449947
• ZFINID: ZDB-GENE-050522-80
• Length: 488
• Species: Danio rerio
• Alignment Length: 630
• Identity: 139/630 - (22%)
• Similarity: 246/630 - (39%)
• Gaps: 181/630 - (28%)

  Fly    40 KDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFL 104
            ::.|:..::||||||||:::.|..:..:......:...:.|.||...|....:..|||.:|....
Zfish    14 QEKKKGGVLPPDGGWGWMIVAGCFVVTVCTRAVTRCISIFFVEFQMHFAKDYSGTAWIHSLVDCT 78

  Fly   105 YSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVY 169
            .....|:.|::..:.|.|...:|||..||:|::||.:|:|:|:||.:.|:|.|:|..|.:.|.:.
Zfish    79 TMLCAPLGSLIGNQLSCRIAVILGGFLASVGLVLSSFATSLEYLYATLGLLTGLGFALCYTPAIA 143

  Fly   170 IVTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPV 234
            :|..||.:.:.||.|:.:|||.:|:.||.|:::.|:|.|.:.|:.||:||..||:.|......|:
Zfish   144 MVGIYFCERKALAYGIAMSGSGIGTFILAPVVQLLIEHYSWRGALLILGGFVLNLCVCGALLRPI 208

  Fly   235 EQHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQ 299
                  :.:..:|.. :|.:.:.|..:|                       ||:   |.|..
Zfish   209 ------ILKEEEACP-LPVDSECGYSVK-----------------------PPT---LNGGP--- 237

  Fly   300 FVRSASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLT 364
             .|||::...|...:|..|:..        :.:|.                :.|..|
Zfish   238 -TRSAASDAKQRCFQSMQEYHF--------LLMPD----------------FLVLAG-------- 269

  Fly   365 LRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSY 429
                             |||.:::   |.:|.|
Zfish   270 -----------------SFLLLAS---GCSLPF-------------------------------- 282

  Fly   430 ADVDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAY 494
                                      :|||                    .:....|.....:|:
Zfish   283 --------------------------VYLV--------------------PYALDVGVGHQHAAF 301

  Fly   495 LLSVVSATDLIGRIGGSALSDMGYIPK----TWYFVGGLSISGLSLALLPFAWTYSSVCFWCALF 555
            |:|::...|::|.|....|:|...:.|    .:.|..|:  .||....:|...|:..:..:..|:
Zfish   302 LMSILGVIDIVGNITFGWLTDRRCLKKYRNICYMFAVGM--EGLCCLFIPLLRTFVWLVPFSVLY 364

  Fly   556 GLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGL 620
            |...|.||.:..|:.:|::|.:.|:|:.|:..|::.:..||.||:..:..:....|...|...|.
Zfish   365 GYFDGAYVALIPVVTSDVVGRQYLSSALGVVYFLHAVPYLVSPPIGGWLVDTTGTYTATFFLSGF 429

  Fly   621 TLLAGASLWSFMPWINR-----RKANAEEQLDAQI--EKAAVDSY 658
            .|:: :||..|...|.|     :|.|:..::...:  |...||.|
Zfish   430 ALIS-SSLLLFSVAIIRYCQRNQKKNSLSKIPKLVSCEGKQVDYY 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	58/175 (33%)
		MFS	<451..633	CDD:475125	42/185 (23%)
slc16a12b	NP_001139286.1	MFS_MCT12	29..430	CDD:340982	120/569 (21%)