Protein Alignment hrm and chk

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Alignment Length: 813
• Identity: 189/813 - (23%)
• Similarity: 315/813 - (38%)
• Gaps: 203/813 - (24%)

  Fly    23 NGNTNESRHKTV-----------SLINKKDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSF 76
            |||....|.|.:           |...||..|     .||||:||:|:..|.:.:::..|...||
  Fly   100 NGNGQVKRRKRLISNESGDSIDSSSTEKKTPK-----MPDGGYGWVVVFASLVVSLIADGLSFSF 159

  Fly    77 GVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFW 141
            |::..|..:.|..|.:|.|||.:|.:.:...:||:.|.|..||..|.:|:|||..::.|..||.:
  Fly   160 GLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSF 224

  Fly   142 ASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLE 206
            .:|||.|.:::|::.|:|.|:.:...|..:..:|.|.|..|.|:..||:.:|:.:...|..:|:|
  Fly   225 CNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIE 289

  Fly   207 TYGYHGSCLIMGGITLNVFV-AALFYEP---VE--------QHMVRVPRARQALENIPEEEDIGI 259
            :||:.|:.||:||..||..| .||..:|   :|        |.:.....:...||.|.:..|.||
  Fly   290 SYGWRGATLILGGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGI 354

  Fly   260 VMKFENVDEPVPKN---------EPADKPLLPYNS------------------------------ 285
            . |...:|..|.||         :|.|..|..|.|
  Fly   355 T-KEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHK 418

  Fly   286 ---------------------PPSPLYL--PGD--------ERLQFVRSASAAVVQSYS------ 313
                                 |||...:  |.|        |..:..:.|..|.:::.|
  Fly   419 EGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRS 483

  Fly   314 ---------KSGDEFQSRSRKISTPVRLPQ----------------------------------- 334
                     :|.||.....:..|:...|.:
  Fly   484 TGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCY 548

  Fly   335 --RNQTFT---PGQLNSQSSLYAVPEGRSSSN-KLTLRNSSKS------RLSK-RSPS------- 379
              :::||.   |.: ..:.::.|:||...|.| :|..|.:...      |||: :.||
  Fly   549 YSKDETFALLEPSR-RIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLR 612

  Fly   380 ------TSSFLYVSTPYHGSTLSFQPKEFSSH-LSLRSMG------SSGTGHAGDSTGQDGSYAD 431
                  .|:|| .....|.:::.::....::| ..||:..      :|.|..|.:.  :|..|.:
  Fly   613 RNISIRNSNFL-KDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEE--EDTWYDN 674

  Fly   432 -VDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFII---LLPSFGEARGFNKSLS 492
             ||.        ....||.||..|..:.:.   |.:....:..|||   .||.:.:...::.|.|
  Fly   675 FVDT--------MKSIFDFSLFLDMKFALF---NLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQS 728

  Fly   493 AYLLSVVSATDLIGRIGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAWT-YSSVCFWCALFG 556
            |.|:|.|.....:|.||...|.|:.::.....:...:.:.|.|:..:|...| |..:...|.:||
  Fly   729 AELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFG 793

  Fly   557 LASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLT 621
            .........|..|:..::..:..|.:||:.|.|.|:..:.|||:....:|....::..|:..|:
  Fly   794 FTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGI- 857

  Fly   622 LLAGASLWSFMPWINRRKANAEEQLDAQIEKAA 654
            .:|.:.:.|::.....:||..|...|....|.|
  Fly   858 FIALSGVCSYLIEFCEKKAPKESDSDVLETKKA 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	62/176 (35%)
		MFS	<451..633	CDD:475125	43/185 (23%)
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	62/176 (35%)
		MFS	<687..869	CDD:475125	43/185 (23%)