DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrm and chk

DIOPT Version :9

Sequence 1:	NP_001286141.1	Gene:	hrm / 35499	FlyBaseID:	FBgn0033028	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	813	Identity:	189/813 - (23%)
Similarity:	315/813 - (38%)	Gaps:	203/813 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NGNTNESRHKTV-----------SLINKKDDKEYDLVPPDGGWGWLVLLGSCLTNILIPGTIKSF 76
            |||....|.|.:           |...||..|     .||||:||:|:..|.:.:::..|...||
  Fly   100 NGNGQVKRRKRLISNESGDSIDSSSTEKKTPK-----MPDGGYGWVVVFASLVVSLIADGLSFSF 159

  Fly    77 GVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFW 141
            |::..|..:.|..|.:|.|||.:|.:.:...:||:.|.|..||..|.:|:|||..::.|..||.:
  Fly   160 GLINVELLEYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSF 224

  Fly   142 ASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLRWLLE 206
            .:|||.|.:::|::.|:|.|:.:...|..:..:|.|.|..|.|:..||:.:|:.:...|..:|:|
  Fly   225 CNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIE 289

  Fly   207 TYGYHGSCLIMGGITLNVFV-AALFYEP---VE--------QHMVRVPRARQALENIPEEEDIGI 259
            :||:.|:.||:||..||..| .||..:|   :|        |.:.....:...||.|.:..|.||
  Fly   290 SYGWRGATLILGGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGI 354

  Fly   260 VMKFENVDEPVPKN---------EPADKPLLPYNS------------------------------ 285
            . |...:|..|.||         :|.|..|..|.|
  Fly   355 T-KEAVLDSLVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHK 418

  Fly   286 ---------------------PPSPLYL--PGD--------ERLQFVRSASAAVVQSYS------ 313
                                 |||...:  |.|        |..:..:.|..|.:::.|
  Fly   419 EGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRS 483

  Fly   314 ---------KSGDEFQSRSRKISTPVRLPQ----------------------------------- 334
                     :|.||.....:..|:...|.:
  Fly   484 TGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCY 548

  Fly   335 --RNQTFT---PGQLNSQSSLYAVPEGRSSSN-KLTLRNSSKS------RLSK-RSPS------- 379
              :::||.   |.: ..:.::.|:||...|.| :|..|.:...      |||: :.||
  Fly   549 YSKDETFALLEPSR-RIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLR 612

  Fly   380 ------TSSFLYVSTPYHGSTLSFQPKEFSSH-LSLRSMG------SSGTGHAGDSTGQDGSYAD 431
                  .|:|| .....|.:::.::....::| ..||:..      :|.|..|.:.  :|..|.:
  Fly   613 RNISIRNSNFL-KDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEE--EDTWYDN 674

  Fly   432 -VDARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFII---LLPSFGEARGFNKSLS 492
             ||.        ....||.||..|..:.:.   |.:....:..|||   .||.:.:...::.|.|
  Fly   675 FVDT--------MKSIFDFSLFLDMKFALF---NLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQS 728

  Fly   493 AYLLSVVSATDLIGRIGGSALSDMGYIPKTWYFVGGLSISGLSLALLPFAWT-YSSVCFWCALFG 556
            |.|:|.|.....:|.||...|.|:.::.....:...:.:.|.|:..:|...| |..:...|.:||
  Fly   729 AELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFG 793

  Fly   557 LASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLT 621
            .........|..|:..::..:..|.:||:.|.|.|:..:.|||:....:|....::..|:..|:
  Fly   794 FTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGI- 857

  Fly   622 LLAGASLWSFMPWINRRKANAEEQLDAQIEKAA 654
            .:|.:.:.|::.....:||..|...|....|.|
  Fly   858 FIALSGVCSYLIEFCEKKAPKESDSDVLETKKA 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	178/773 (23%)
		MFS	59..>234	CDD:119392	60/178 (34%)
		MFS	<449..633	CDD:119392	44/187 (24%)
chk	NP_001163063.1	MFS	143..>315	CDD:119392	59/171 (35%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	44/187 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4618
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I274
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm25394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	8	7.960