Protein Alignment hrm and Slc16a12

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_766426.1
• Gene: Slc16a12 / 240638
• MGIID: 2147716
• Length: 486
• Species: Mus musculus
• Alignment Length: 593
• Identity: 126/593 - (21%)
• Similarity: 226/593 - (38%)
• Gaps: 169/593 - (28%)

  Fly    49 PPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSS 113
            ||||||||:::.|..|..|......:...:.|.||...|....::.|||.::...:.....|:.|
Mouse    12 PPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGS 76

  Fly   114 ILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKL 178
            ::|.:.|.:...:|||..||.|.||..:|:|::.||:|.|||.|:|..|.:.|.:.:|..||::.
Mouse    77 VVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRR 141

  Fly   179 RGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPR 243
            :.||.|:.:|||.:|:.||.|:::.|:|.:.:.|:.||:||..||:.|......|:
Mouse   142 KALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPI--------- 197

  Fly   244 ARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAV 308
                  .:.|:..:
Mouse   198 ------TLKEDRSV--------------------------------------------------- 205

  Fly   309 VQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKSRL 373
                                    |::|.                       |:.:.|...|.
Mouse   206 ------------------------PEKNH-----------------------NRESQREDCKQ-- 221

  Fly   374 SKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDARGQA 438
                         ::||  |.|:.:..|.....||
Mouse   222 -------------ASPY--SPLTKECTETRLCCSL------------------------------ 241

  Fly   439 QQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSVVSATD 503
            ||.     :...|:.|  ::|:.:|....|...:...:.|..:..:.|.:...:|:|:|::...|
Mouse   242 QQE-----YGFLLMSD--FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVID 299

  Fly   504 LIGRIGGSALSDMGYIPKTWY--FVGGLSISGLSLALLPFAWTYSSVCFWCALFGLASGIYVGIT 566
            ::|.|....|:|...:....|  ::..:::.||....||...|:..:..:...||...|.||.:.
Mouse   300 IVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLI 364

  Fly   567 AVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLTLLAGASLWSF 631
            .|:.|:::||..|:|:.|:..|::.:..||.||:..:..:....|...|...|..::..:.|..|
Mouse   365 PVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGF 429

  Fly   632 MPWINRRK 639
            :..:.|.|
Mouse   430 VRIVKRMK 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	59/175 (34%)
		MFS	<451..633	CDD:475125	43/183 (23%)
Slc16a12	NP_766426.1	MFS_MCT12	18..431	CDD:340982	118/579 (20%)