Protein Alignment hrm and SLC16A8

DIOPT Version :9

• Sequence 1: NP_001286141.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_037488.2
• Gene: SLC16A8 / 23539
• HGNCID: 16270
• Length: 504
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 139/587 - (23%)
• Similarity: 225/587 - (38%)
• Gaps: 184/587 - (31%)

  Fly    49 PPDGGWGWLVLLGSC--LTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPV 111
            |||||||| |:||:|  :|.... |..|:..|.|......|::..:..||:.::...:....|||
Human    12 PPDGGWGW-VVLGACFVVTGFAY-GFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPV 74

  Fly   112 SSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFA 176
            ||||..::..|.|.|.||..||.||||:.:|:.:..||::.|||.|:|..|:|.|::.::..||.
Human    75 SSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFE 139

  Fly   177 KLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRV 241
            :.|.|||||..:||.:....|.||.:.|||.:|:.|..|::||:.|:....
Human   140 RRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCAC-------------- 190

  Fly   242 PRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASA 306
                            |.||:                       ||     ||
Human   191 ----------------GAVMR-----------------------PP-----PG------------ 199

  Fly   307 AVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNSSKS 371
                                              ||           |..|        |:|:..
Human   200 ----------------------------------PG-----------PRPR--------RDSAGD 211

  Fly   372 RLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQ---DGSYADVD 433
            |                                              |||:.|:   ||:...:.
Human   212 R----------------------------------------------AGDAPGEAEADGAGLQLR 230

  Fly   434 ARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSV 498
            ......:|:| :..||::..|..:.|..::....|:......|||.::.:..|...:.:|:|||:
Human   231 EASPRVRPRR-RLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSI 294

  Fly   499 VSATDLIGRIGGSALSDMG----YIPKTWYFVGGLSISGLSLALLPFAWTYSSVCFWCALFGLAS 559
            |...|::.|....||:.:.    ::|  :.|...|..:||:......|.:|.::..:|..|||:.
Human   295 VGFVDIVARPACGALAGLARLRPHVP--YLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSY 357

  Fly   560 GIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLTL-L 623
            |:...:...::...:|..|..|:.|:.|.|.....|:|||......:.:.:|..:|:..|..: |
Human   358 GMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVAL 422

  Fly   624 AG 625
            ||
Human   423 AG 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	139/587 (24%)
		MFS	59..>234	CDD:119392	62/176 (35%)
		MFS	<449..633	CDD:119392	45/182 (25%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	139/587 (24%)
		MFS	19..429	CDD:119392	132/580 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..224		15/143 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..504

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm9818
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920