Protein Alignment hrm and mct-5

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_495464.2
• Gene: mct-5 / 187995
• WormBaseID: WBGene00020168
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 644
• Identity: 157/644 - (24%)
• Similarity: 271/644 - (42%)
• Gaps: 131/644 - (20%)

  Fly    48 VPPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVS 112
            :||||||||:|::||...::...|.:.|||:|..:....|||:.|..:.|.::........||::
 Worm    13 LPPDGGWGWVVVIGSFFIHVFADGFVYSFGILAEKLMIEFNSNNTMTSLIVSMLTGFTLGAGPLA 77

  Fly   113 SILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAK 177
            |.:..||..|..|::|...|.:|.:||.:|:.|....||.||::|||.||.:.|.:.|||.||..
 Worm    78 SAVCNKYGCRITTIIGAGVAFVGCLLSCFATEIWHFVISVGVIMGIGFGLVYCPAIVIVTMYFES 142

  Fly   178 LRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALF-----------Y 231
            .|.||.|:.::|:.:|:::..|:..:::..||:.           .|||..||           :
 Worm   143 KRSLATGIAVAGAGVGAVVFGPINTFIISNYGWR-----------YVFVLFLFVIILCAVCGATF 196

  Fly   232 EPVEQHMVRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYN----------SP 286
            .|::..:|            |:::|.|   ::.:|.|...|.       :.||          ||
 Worm   197 VPLQFALV------------PDDDDDG---EYNDVFEDEVKK-------IDYNKRFEEKVSLLSP 239

  Fly   287 PSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLY 351
            |..|                                .|.:|....:.:.||...|     .||:.
 Worm   240 PQVL--------------------------------ERSMSQCCDIQKNNQHARP-----SSSVG 267

  Fly   352 AV---PEGRSSSNKLTLRNSSKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGS 413
            ||   |..|.....:..|||  ..|:::     ...|..:..:.:.....|.::.|..||.:..:
 Worm   268 AVDLEPLLRPRCGTIGERNS--GYLNRK-----DVFYTGSISNVAEFRANPDKYRSTGSLHTALN 325

  Fly   414 SGTGHAGDSTGQD---GSYADVDARGQAQQPQR---------------SKFFDLSLLKDPMYLVI 460
            ..|.|.| :.|.|   |...|....|..::.:.               :..|...||.||.:|:.
 Worm   326 IHTHHTG-TVGDDRESGHGCDQSLDGMNEKKETDFMDDIEGSNMFKTINNMFSFQLLLDPAFLLF 389

  Fly   461 LISNSTNAISYTNFIILLPSFGEARGFNKSLSAYLLSVVSATDLIGRIGGSALSDMGY-IP---- 520
            .|||...::.:.:.:..||........:.::|..:|||....:.|||:....::|... :|
 Worm   390 AISNLLTSVGFNSPLYFLPLHVTNILSDNNVSGNILSVYGTANTIGRLIFGVVADQKLPLPAGLG 454

  Fly   521 ------KTWYFVGGLSISGLSLALLPFAWTYSSVCFWCALFGLASGIYVGITAVIMADMLGTERL 579
                  :.|.:...|:|.|:..|.......|..:..:..|||.....||.:|:||:.|:||.::|
 Worm   455 DDTARNRLWMYNISLTICGIVTAFCYKFDGYILLDIYAVLFGFTIASYVCLTSVILVDLLGLDKL 519

  Fly   580 TSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHALGLTLLAGASLWSFMPWINRR 638
            |:::|:.|...|:..::||.:..|..:...:|...|...|:.|:....:...:|:..|:
 Worm   520 TNAFGLLLLWQGVGTVIGPLVSGYLADLTGNYTLSFVFCGINLMVSGLMLFVIPYFKRK 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	58/186 (31%)
		MFS	<451..633	CDD:475125	48/192 (25%)
mct-5	NP_495464.2	MFS_MCT_SLC16	20..573	CDD:340910	149/630 (24%)