Protein Alignment hrm and gem-1

DIOPT Version :10

• Sequence 1: NP_610174.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_001379120.1
• Gene: gem-1 / 181458
• WormBaseID: WBGene00008214
• Length: 771
• Species: Caenorhabditis elegans
• Alignment Length: 768
• Identity: 153/768 - (19%)
• Similarity: 281/768 - (36%)
• Gaps: 184/768 - (23%)

  Fly    16 NQKDHKPNGNTNESRHKTVSLINKKDDKEYDLVP--------PDGGWGWLVLLGSCLTNILIPGT 72
            ||:...|:............:..:.||.:.:.|.        .|||:||||:|.|.|.:.:..|.
 Worm    25 NQQPFSPSDEPRVRFEAPAPVSARSDDSDAESVESLTERPVYKDGGYGWLVVLASFLMHAVCDGA 89

  Fly    73 IKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMI 137
            ...||::|.:..:.|......:....::...|...:.||:.|:|.....|...::|.:..::..|
 Worm    90 SFCFGIVFVKIQEHFQCGRFVSMITASMFLSLPLIMSPVAGIVSDILGCRMSIIIGASICTVSCI 154

  Fly   138 LSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLR 202
            ::.:.|.|.|..||:|:..|:|....:...:.|||.||.|.||||....:||:.:|::|.|.||.
 Worm   155 IAMFCSHIFFFMISFGLGCGVGMSFIYNAAIVIVTYYFEKRRGLATSFAVSGTGVGTVIYPILLN 219

  Fly   203 WLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENV- 266
            .         |.:.:.....::.:..:|:..:...:..:....:.:|...::.|..: .||:..
 Worm   220 L---------SMIYLASFVSDIRIILIFFAVMYFVIAVIGFFIKDVEWESDKTDFKL-RKFQKYI 274

  Fly   267 ----DEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKIS 327
                ||......|.|..:....|.|:         |..:.:.|.: :||...:.    ...||..
 Worm   275 AKMDDEKENNTNPTDAFMRHAISLPN---------LNILNNHSGS-IQSICDAA----KAERKSD 325

  Fly   328 TPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKL----------------TLRNSSKSRLSKR 376
            .|.|      :.:....:::..:.::||....:..|                |:|...:..:||.
 Worm   326 KPTR------SKSVALFDNKHQMSSIPEYSMLNTNLANLEHLDLELANSPCTTVRAQRRRVISKV 384

  Fly   377 SPSTSSF-------LYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDA 434
            |.|....       .:::. :..||.|....|.||       ..|...:.|||:..:.|..::|.
 Worm   385 SMSVDQINELEDEAFHINL-FQSSTESESDDESSS-------DDSEMSNDGDSSSSELSEKNLDE 441

  Fly   435 ---------------RGQAQQPQRSKFFDLSLLKDPMYLV---ILISNSTNAISYTNFIIL--LP 479
                           |..:..|..::....|:......:.   ::.||:..:...||.|.:  :|
 Worm   442 PTTKLINKNLENVAFRATSSVPNSARMNRNSVAAGTSNMFGGRVIASNAIQSRHATNLIAMGKIP 506

  Fly   480 S-------------FGE-ARGFNKS--------------LSAYLLSVVSATDLIGRIGGSALSDM 516
            |             .|: .:||.|.              ..||:...:|...|.      .:.|:
 Worm   507 SAPMLVARKNRKSMIGKPIQGFYKKWLETEKPIYQEVIHCRAYIYLALSVLCLY------FILDV 565

  Fly   517 GYIPKTWYFVGGLSIS-----------GLS--LALLPFA----WTYSSVCFWCALFGLASGIYVG 564
            .|:....|.:..|.:.           |:|  :::|.|.    ||...:....|    :|.:.||
 Worm   566 PYVCFYEYSIDTLKMEESEANYIYYSIGISNFISVLLFGTLADWTRKHITTIYA----SSMVGVG 626

  Fly   565 IT------------AVIMADMLGTERLTSSY------------GISLF---------VNGLLQLV 596
            ||            .||:....|. .:||:|            .::||         :.|:..|:
 Worm   627 ITIMFSTRINSLVELVIVGVCFGV-TITSNYVLQSILVTICFEDVNLFQVAYSLIAMIEGVASLI 690

  Fly   597 GPPLCNYWFEAVNDYNPLFHALGLTLLA-GASLWSFMPWINRRKANAEEQLDA 648
            |||:.....||...|..:|...|:..|| |...:.|...:|:|....::.:::
 Worm   691 GPPIFALVREATGGYTVVFFISGIFALASGFFGFMFSYEMNKRNTGDKDSIES 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_610174.1	MFS_MCT_SLC16	55..>231	CDD:340910	46/175 (26%)
		MFS	<451..633	CDD:475125	53/265 (20%)
gem-1	NP_001379120.1	MFS	72..>254	CDD:475125	47/190 (25%)
		MFS	<543..727	CDD:475125	41/194 (21%)