DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hrm and gem-1

DIOPT Version :9

Sequence 1:	NP_001286141.1	Gene:	hrm / 35499	FlyBaseID:	FBgn0033028	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	NP_001379120.1	Gene:	gem-1 / 181458	WormBaseID:	WBGene00008214	Length:	771	Species:	Caenorhabditis elegans

Alignment Length:	768	Identity:	153/768 - (19%)
Similarity:	281/768 - (36%)	Gaps:	184/768 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NQKDHKPNGNTNESRHKTVSLINKKDDKEYDLVP--------PDGGWGWLVLLGSCLTNILIPGT 72
            ||:...|:............:..:.||.:.:.|.        .|||:||||:|.|.|.:.:..|.
Worm    25 NQQPFSPSDEPRVRFEAPAPVSARSDDSDAESVESLTERPVYKDGGYGWLVVLASFLMHAVCDGA 89

  Fly    73 IKSFGVLFSEFTDAFNSSPTKAAWIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMI 137
            ...||::|.:..:.|......:....::...|...:.||:.|:|.....|...::|.:..::..|
Worm    90 SFCFGIVFVKIQEHFQCGRFVSMITASMFLSLPLIMSPVAGIVSDILGCRMSIIIGASICTVSCI 154

  Fly   138 LSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIILPPLLR 202
            ::.:.|.|.|..||:|:..|:|....:...:.|||.||.|.||||....:||:.:|::|.|.||.
Worm   155 IAMFCSHIFFFMISFGLGCGVGMSFIYNAAIVIVTYYFEKRRGLATSFAVSGTGVGTVIYPILLN 219

  Fly   203 WLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHMVRVPRARQALENIPEEEDIGIVMKFENV- 266
            .         |.:.:.....::.:..:|:..:...:..:....:.:|...::.|..: .||:..
Worm   220 L---------SMIYLASFVSDIRIILIFFAVMYFVIAVIGFFIKDVEWESDKTDFKL-RKFQKYI 274

  Fly   267 ----DEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRSASAAVVQSYSKSGDEFQSRSRKIS 327
                ||......|.|..:....|.|:         |..:.:.|.: :||...:.    ...||..
Worm   275 AKMDDEKENNTNPTDAFMRHAISLPN---------LNILNNHSGS-IQSICDAA----KAERKSD 325

  Fly   328 TPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKL----------------TLRNSSKSRLSKR 376
            .|.|      :.:....:::..:.::||....:..|                |:|...:..:||.
Worm   326 KPTR------SKSVALFDNKHQMSSIPEYSMLNTNLANLEHLDLELANSPCTTVRAQRRRVISKV 384

  Fly   377 SPSTSSF-------LYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVDA 434
            |.|....       .:::. :..||.|....|.||       ..|...:.|||:..:.|..::|.
Worm   385 SMSVDQINELEDEAFHINL-FQSSTESESDDESSS-------DDSEMSNDGDSSSSELSEKNLDE 441

  Fly   435 ---------------RGQAQQPQRSKFFDLSLLKDPMYLV---ILISNSTNAISYTNFIIL--LP 479
                           |..:..|..::....|:......:.   ::.||:..:...||.|.:  :|
Worm   442 PTTKLINKNLENVAFRATSSVPNSARMNRNSVAAGTSNMFGGRVIASNAIQSRHATNLIAMGKIP 506

  Fly   480 S-------------FGE-ARGFNKS--------------LSAYLLSVVSATDLIGRIGGSALSDM 516
            |             .|: .:||.|.              ..||:...:|...|.      .:.|:
Worm   507 SAPMLVARKNRKSMIGKPIQGFYKKWLETEKPIYQEVIHCRAYIYLALSVLCLY------FILDV 565

  Fly   517 GYIPKTWYFVGGLSIS-----------GLS--LALLPFA----WTYSSVCFWCALFGLASGIYVG 564
            .|:....|.:..|.:.           |:|  :::|.|.    ||...:....|    :|.:.||
Worm   566 PYVCFYEYSIDTLKMEESEANYIYYSIGISNFISVLLFGTLADWTRKHITTIYA----SSMVGVG 626

  Fly   565 IT------------AVIMADMLGTERLTSSY------------GISLF---------VNGLLQLV 596
            ||            .||:....|. .:||:|            .::||         :.|:..|:
Worm   627 ITIMFSTRINSLVELVIVGVCFGV-TITSNYVLQSILVTICFEDVNLFQVAYSLIAMIEGVASLI 690

  Fly   597 GPPLCNYWFEAVNDYNPLFHALGLTLLA-GASLWSFMPWINRRKANAEEQLDA 648
            |||:.....||...|..:|...|:..|| |...:.|...:|:|....::.:::
Worm   691 GPPIFALVREATGGYTVVFFISGIFALASGFFGFMFSYEMNKRNTGDKDSIES 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	147/735 (20%)
		MFS	59..>234	CDD:119392	43/174 (25%)
		MFS	<449..633	CDD:119392	54/267 (20%)
gem-1	NP_001379120.1	MFS	72..>254	CDD:421695	47/190 (25%)
gem-1	NP_001379120.1	MFS	<543..727	CDD:421695	41/194 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820