Protein Alignment hrm and SLC16A10

DIOPT Version :9

• Sequence 1: NP_001286141.1
• Gene: hrm / 35499
• FlyBaseID: FBgn0033028
• Length: 658
• Species: Drosophila melanogaster
• Sequence 2: NP_061063.2
• Gene: SLC16A10 / 117247
• HGNCID: 17027
• Length: 515
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 125/624 - (20%)
• Similarity: 224/624 - (35%)
• Gaps: 214/624 - (34%)

  Fly    49 PPDGGWGWLVLLGSCLTNILIPGTIKSFGVLFSEFTDAFNSSPT-----KAAWIPALCYFLYSSL 108
            ||:|||||||:|.:...|..:.|...:.||||....:.|.|...     |.||:.:|...:....
Human    64 PPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFC 128

  Fly   109 GPVSSILSVKYSYRTVTLLGGASASLGMILSFWASSIEFLYISYGVLVGIGAGLSFPPTVYIVTS 173
            .|:.|:.:..:..|...::|.|...:|::.|.:.||||.||::||::...|...::.|::.|:..
Human   129 CPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGH 193

  Fly   174 YFAKLRGLANGLCISGSALGSIILPPLLRWLLETYGYHGSCLIMGGITLNVFVAALFYEPVEQHM 238
            ||.|..||.||:..:||::.:|:||.|||.|:::.|..        .||.|....:|.
Human   194 YFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLF--------YTLRVLCIFMFV------- 243

  Fly   239 VRVPRARQALENIPEEEDIGIVMKFENVDEPVPKNEPADKPLLPYNSPPSPLYLPGDERLQFVRS 303
                                                               |:|.|
Human   244 ---------------------------------------------------LFLAG--------- 248

  Fly   304 ASAAVVQSYSKSGDEFQSRSRKISTPVRLPQRNQTFTPGQLNSQSSLYAVPEGRSSSNKLTLRNS 368
                                             .|:.|                       |..|
Human   249 ---------------------------------FTYRP-----------------------LATS 257

  Fly   369 SKSRLSKRSPSTSSFLYVSTPYHGSTLSFQPKEFSSHLSLRSMGSSGTGHAGDSTGQDGSYADVD 433
            :|.:.|..|              ||:| |..|:||
Human   258 TKDKESGGS--------------GSSL-FSRKKFS------------------------------ 277

  Fly   434 ARGQAQQPQRSKFFDLSLLKDPMYLVILISNSTNAISY-TNFIILLPSFGEARGFNKSLSAYLLS 497
                   |.: |.|:.::.|...|.|..:........| ..::.|:....| |..::.....:|.
Human   278 -------PPK-KIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNE-RFQDEKNKEVVLM 333

  Fly   498 VVSATDLIGRIGGSALSDMGYIP---------KTWYFVGGLSISGLSLALLPFAWTYSSVCFWCA 553
            .:..|..:||:....::|  |:|         .:::|:|.:|:      ::|....:.::...|.
Human   334 CIGVTSGVGRLLFGRIAD--YVPGVKKVYLQVLSFFFIGLMSM------MIPLCSIFGALIAVCL 390

  Fly   554 LFGLASGIYVGITAVIMADMLGTERLTSSYGISLFVNGLLQLVGPPLCNYWFEAVNDYNPLFHAL 618
            :.||..|.::.|.|.|..:::|.:.::.:.|..|....:...||||:.....:.:..|:..|:..
Human   391 IMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLA 455

  Fly   619 GLTLLAGASLWSFMPWINRR------KANAEEQLDAQIE 651
            |:..|.|.::..|:|||:.:      |...:|:::..:|
Human   456 GVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hrm	NP_001286141.1	2A0113	49..653	CDD:273325	125/624 (20%)
		MFS	59..>234	CDD:119392	52/179 (29%)
		MFS	<449..633	CDD:119392	38/193 (20%)
SLC16A10	NP_061063.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		2A0113	67..487	CDD:273325	121/612 (20%)
		MFS	71..470	CDD:119392	113/591 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820