Protein Alignment TpnC4 and CALM3

DIOPT Version :10

• Sequence 1: NP_610173.2
• Gene: TpnC4 / 35498
• FlyBaseID: FBgn0033027
• Length: 153
• Species: Drosophila melanogaster
• Sequence 2: NP_005175.2
• Gene: CALM3 / 808
• HGNCID: 1449
• Length: 149
• Species: Homo sapiens
• Alignment Length: 152
• Identity: 56/152 - (36%)
• Similarity: 96/152 - (63%)
• Gaps: 5/152 - (3%)

  Fly     1 MADGEYDKEQLRILRNAFKAFDHDGAGSIEHADVSSILEILGQKLEPPAVKALIKEVDKGTTGKL 65
            ||| :..:||:...:.||..||.||.|:|...::.:::..|||......::.:|.|||....|.:
Human     1 MAD-QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTI 64

  Fly    66 DFSQFCKLAARFIEVEEDVGALQNELKEAFRVYDKEGKGYLTVATLRGILHELDDKLSNQDLDMI 130
            ||.:|..:.||.::..:.    :.|::|||||:||:|.||::.|.||.::..|.:||:::::|.:
Human    65 DFPEFLTMMARKMKDTDS----EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEM 125

  Fly   131 IEEIDADGSGTVDFDEFMQVMT 152
            |.|.|.||.|.|:::||:|:||
Human   126 IREADIDGDGQVNYEEFVQMMT 147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TpnC4	NP_610173.2	PTZ00184	1..152	CDD:185504	54/150 (36%)
CALM3	NP_005175.2	PTZ00184	1..149	CDD:185504	56/152 (37%)
		Necessary and sufficient for interaction with PCP4. /evidence=ECO:0000269|PubMed:27876793	77..149		30/75 (40%)