DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TpnC4 and EFCAB3

DIOPT Version :9

Sequence 1:	NP_001163055.1	Gene:	TpnC4 / 35498	FlyBaseID:	FBgn0033027	Length:	153	Species:	Drosophila melanogaster
Sequence 2:	NP_001138405.1	Gene:	EFCAB3 / 146779	HGNCID:	26379	Length:	490	Species:	Homo sapiens

Alignment Length:	159	Identity:	37/159 - (23%)
Similarity:	70/159 - (44%)	Gaps:	34/159 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DGAGSIEHADVSSILEILGQKLEPPAVKALIK-----EVDKGTTG---------KLDFSQFCKLA 74
            :|.|.|   :|:||:|.| :|.:|..:..|.|     ::....||         ||..:...|:.
Human    11 NGNGKI---NVNSIMEGL-KKFKPKGMVTLHKLKTANDIKDRVTGHMAVSEIKPKLKLNPLTKVP 71

  Fly    75 ARFIEVEEDV-GALQNEL---------------KEAFRVYDKEGKGYLTVATLRGILHELDDKLS 123
            ....:.:.|: |:||.:|               ::|:..:.|:..|.:....|...:.:|...|:
Human    72 ISHNKRDRDLPGSLQCQLQHKEKKLSASQMAAFQDAYNFFYKDKTGCIDFHGLMCTVAKLGMNLT 136

  Fly   124 NQDLDMIIEEIDADGSGTVDFDEFMQVMT 152
            ..|:...::..|.|..|.|:|.:|::|:|
Human   137 KHDVYNELKCADIDRDGKVNFSDFIKVLT 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TpnC4	NP_001163055.1	PTZ00184	1..152	CDD:185504	36/157 (23%)
		EFh	14..75	CDD:238008	17/64 (27%)
		EFh	90..152	CDD:238008	15/76 (20%)
EFCAB3	NP_001138405.1	EF-hand_8	115..167	CDD:290545	13/51 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143665
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930