Protein Alignment CG30440 and KALRN

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_006713873.1
• Gene: KALRN / 8997
• HGNCID: 4814
• Length: 2988
• Species: Homo sapiens
• Alignment Length: 1038
• Identity: 254/1038 - (24%)
• Similarity: 409/1038 - (39%)
• Gaps: 289/1038 - (27%)

  Fly    36 IHEGKKAI-MYRSSEPQIAARRNKKTRFVGNRRQLRNLSQPENSHKTSRSLCPDTAKT------- 92
            |.||:..| ..||:.|.:......:...|.|.:...:.|   .||..|.....|.|:.
Human   700 IKEGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSS---ISHIESVLQQLDDAQVQMEELFH 761

  Fly    93 EPKV-----YSLR----FVLNKSEDKDYMSR--LKAQNDF-SQSSCLCNNLSHANTEAGAYQN-- 143
            |.|:     ..||    :.:..:.:.|..:.  |:..||| ::...|.......:||.....|
Human   762 ERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNM 826

  Fly   144 --DGILKGQRDHSDFLT--AAGGIQSRADR---IA--------------------------RIET 175
              :.|.:|| |...::|  .|.||:...::   :|                          |:|.
Human   827 TFEVIQQGQ-DLHQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQ 890

  Fly   176 CGIRTTHLQPET-QILKPVTEPNETRFDQHSPDWLFKNSRIGDVS--NSSKLSACNSELPPEEYK 237
            | ::..|||.|. |:|                .|:.....:.:.|  |:|.||  .:|....|::
Human   891 C-LQLRHLQAEVKQVL----------------GWIRNGESMLNASLVNASSLS--EAEQLQREHE 936

  Fly   238 G-----RTLYHDTKFDCAYIKNRRPLITTESKMSI-TEAEHPQTKYTDIKYD---YKTCSISQGL 293
            .     .:|:|.|...    |..:..:..:.|..: .:|.|         ||   .:.|:....|
Human   937 QFQLAIESLFHATSLQ----KTHQSALQVQQKAEVLLQAGH---------YDADAIRECAEKVAL 988

  Fly   294 HQNKAFLN----------KVPPSKQSKPFHSVDYDYYENIQKLHLSKESERQIRDN-GDPNDLQN 347
            |..:..|.          .|...|.|:...||    .|::::.:...|.....||. |...::.:
Human   989 HWQQLMLKMEDRLKLVNASVAFYKTSEQVCSV----LESLEQEYRRDEDWCGGRDKLGPAAEIDH 1049

  Fly   348 FL---------KKNLIKATT----------------NELLKAAAQSTKKCNIDLERKLNDLNIKE 387
            .:         |:..:||.|                |..:.:.|..|:.....::..|::| ::.
Human  1050 VIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSEL-LQR 1113

  Fly   388 EDHTSNDSGNSYKNDPYLVSMSKINSCK----FIRSYNRDCETIFPTGD-----HSDLNEFRKSF 443
            |:...:.         :.:...:::.|:    |.||..:..:.|..||:     |:...|..:
Human  1114 ENRVLHF---------WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTE-- 1167

  Fly   444 MPQSVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCL----NAVEE 504
              ::.:||.                           |..|::..|....|..|..:    :.||:
Human  1168 --ETQELLK---------------------------EYGEFRVPAKQTKEKVKLLIQLADSFVEK 1203

  Fly   505 GVFCNTE-----------YDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESG 558
            |....||           |.||...:       |.:
Human  1204 GHIHATEIRKWVTTVDKHYRDFSLRM-------GKY----------------------------- 1232

  Fly   559 TDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKS---NEIFKKPQDPEMQRHRR- 619
               :.|.:..|...|||..|               |.:..:|.|   .|:..:..:.|:...:|
Human  1233 ---RYSLEKALGVNTEDNKD---------------LELDIIPASLSDREVKLRDANHEVNEEKRK 1279

  Fly   620 -----GHILKELFETEKIYVNEIASILKGY-YDRLKSDESAPASLQGKANVLFGNLNEIYSFHND 678
                 ..|:.||.:|||.||.::...|:.| ::.....|..|..:..|.:::|||:.|||.|||:
Human  1280 SARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNN 1344

  Fly   679 VFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHK 743
            :|||:||....:.|.|..|||...||| |:|..||:|...|.:|  .|.....||.|.|...|..
Human  1345 IFLKELEKYEQLPEDVGHCFVTWADKF-QMYVTYCKNKPDSNQL--ILEHAGTFFDEIQQRHGLA 1406

  Fly   744 LPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSG 808
            ..:.:||:||||||||||||||:||  |..:..:.|||:.|:.||.|.|..||:||...:.||..
Human  1407 NSISSYLIKPVQRITKYQLLLKELL--TCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDE 1469

  Fly   809 DLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQ-TSKSGYNKSSYQFKSDV 872
            :|..||||::||:|||| :.|..||   |.:.||:||::.||:..|: ...||:.|  |.:|:.:
Human  1470 NLDVQGELILQDAFQVW-DPKSLIR---KGRERHLFLFEISLVFSKEIKDSSGHTK--YVYKNKL 1528

  Fly   873 KMSQIGLTESVSGDAKRFEVWLKGR----QEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKG 931
            ..|::|:||.|.||..:|.:| .||    .....|:||.|..|:.|:..|:.|:..::..|||
Human  1529 LTSELGVTEHVEGDPCKFALW-SGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKG 1590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	75/174 (43%)
		PH-like	802..925	CDD:302622	48/127 (38%)
		PH	829..922	CDD:278594	34/97 (35%)
KALRN	XP_006713873.1	SEC14	41..179	CDD:214706
		SPEC	192..412	CDD:238103
		SPEC	313..538	CDD:238103
		SPEC	539..768	CDD:238103	17/70 (24%)
		SPEC	893..1131	CDD:238103	47/282 (17%)
		SPEC	<1101..1240	CDD:295325	29/218 (13%)
		RhoGEF	1286..1456	CDD:238091	75/174 (43%)
		PH1_Kalirin_Trio_like	1463..1585	CDD:270060	48/128 (38%)
		PH	1496..1581	CDD:278594	30/87 (34%)
		SH3_Kalirin_1	1651..1710	CDD:212786
		SH3-RhoG_link	1708..1934	CDD:293215
		RhoGEF	1935..2105	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061
		PH	2142..2228	CDD:278594
		SH3_Kalirin_2	2327..2385	CDD:212787
		I-set	2473..2567	CDD:254352
		Ig	2490..2564	CDD:143165
		FN3	2571..2662	CDD:238020
		S_TKc	2686..2940	CDD:214567
		STKc_Kalirin_C	2692..2939	CDD:271017

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5845
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860