Protein Alignment CG30440 and ROM1

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_011584.2
• Gene: ROM1 / 852961
• SGDID: S000003302
• Length: 1155
• Species: Saccharomyces cerevisiae
• Alignment Length: 789
• Identity: 154/789 - (19%)
• Similarity: 277/789 - (35%)
• Gaps: 220/789 - (27%)

  Fly   202 DQHSPDWLFKNSRIGDVSNSSKLSACNSELPPEE---------YKGRTLYHDTKF------DC-A 250
            |..:|..||..|::  .:|.:::|..|.|  .|:         .|..||.|||..      || :
Yeast    24 DTSTPTQLFSGSKV--QTNINEISITNDE--DEDSTEDENKASLKDYTLGHDTGARYRIAPDCSS 84

  Fly   251 YIKNRRPLITTESKMSITEAEHPQTKYTD-IKYDYKTCSISQGLHQ---NKAFLNKVPPSKQSKP 311
            :.....|::...:.::    ..||:...| |....|..||:....|   |.......|..|:|
Yeast    85 HQLKASPVLHISTNLN----SSPQSFTGDQISPTNKKISINDSTRQDKGNSCTTTSSPSQKRS-- 143

  Fly   312 FHSVDYDYYENIQKLHLSKESERQI--------RDNGDPNDL----------------QNFLKKN 352
                      |:...|:.|.|...:        ...||||.|                .:|..|:
Yeast   144 ----------NVLLPHVRKHSSPSLLSFSKNSGSHMGDPNQLSTPPTPKSAGHTMELHSSFNGKH 198

  Fly   353 LIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKEE--DHTSNDSGNSYKNDPYLVSMSKINSCK 415
            ...:|::..   |.:|.|..|   .|..|..|...:  .||:....:..::....||:::|:..|
Yeast   199 SSSSTSSLF---ALESLKTQN---RRSSNSSNHSSQYRRHTNQHQRHHSRSKSSPVSLTEISMIK 257

  Fly   416 FIRSYNRDCETIFPT---------------GDHSDLN-EFRKSFM-PQSVD----LLSSASVSLS 459
                   ....::|.               ..|..:. .:|.||. .|::|    ::.|...:|.
Yeast   258 -------GTPLVYPALLSLIAIKFKQTIKLSTHKKMGLLYRDSFTGKQAIDTLCLIIGSLDRNLG 315

  Fly   460 SCDGSCLN--------------KDSICG----SEEDCCECNEYQCIATPPNEL--SKDCLNAVEE 504
            ...|..|.              :||:..    |.|.....::.|...:..|..  |...:|::..
Yeast   316 MLIGKSLEAQKLFHDVLYDHGVRDSVLEIYELSSESIFMAHQSQSSTSIANTFSSSSSSVNSLRT 380

  Fly   505 -----GVFCNTEYDDFHENLTSSCCCSGSFCDDDGC-SYLDEGLSVDIK-----SKNVQSLHESG 558
                 |||....:      ..||.|.....|....| :.|.:..::.:|     .:|:....:..
Yeast   381 KTEIYGVFVPLTH------CYSSTCSLEKLCYSISCPNRLQQQANLHLKLGGGLKRNISLALDKE 439

  Fly   559 TDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHIL 623
            .||::|.          ||.|.:.:.:..:                         .|:.:|...:
Yeast   440 DDERISW----------TNSVPKSVWESLS-------------------------KQQIKRQEAI 469

  Fly   624 KELFETEKIYVNEIASILKGYYDRLKSDESAPASLQ-GKANVLFGNLNEIYSFHNDVFLKDLEN- 686
            .|||.|||.:|..:..|...:..:|......|:.:: .....:|.::|||||.:.: |||.|..
Yeast   470 YELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAHINEIYSVNRE-FLKALAQR 533

  Fly   687 ------CISVTERVALCFVKRRDKFYQL-----YSFYCQNIQRSEKLRETLVDTHMFFKECQIGL 740
                  |..:.: :.|.::...|.|...     |:.|....|||........|..:.....:.|
Yeast   534 QSLSPICPGIAD-IFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNPNFARFDDEVSNSSLRHG- 596

  Fly   741 GHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITG 805
                 :.::|.:.|.|..:|.||:::::.|:|..:.:::|:    .::.|...:.|.|.:|...
Yeast   597 -----IDSFLSQGVSRPGRYSLLVREIIHFSDPVTDKDDLQ----MLMKVQDLLKDLMKRIDRA- 651

  Fly   806 FSGDLAKQGELLMQDSFQVWIESKK------DIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKS 864
             ||        ..||.:.|.:..:|      .:.|.:..::|.|  ..:.||     |:...||:
Yeast   652 -SG--------AAQDRYDVKVLKQKILFKNEYVNLGLNNEKRKI--KHEGLL-----SRKDVNKT 700

  Fly   865 SYQFKSDVK 873
            ...|..|::
Yeast   701 DASFSGDIQ 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	41/186 (22%)
		PH-like	802..925	CDD:473070	16/78 (21%)
ROM1	NP_011584.2	ROM1	1..1155	CDD:227709	154/789 (20%)