Protein Alignment CG30440 and TIAM1

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_003244.2
• Gene: TIAM1 / 7074
• HGNCID: 11805
• Length: 1591
• Species: Homo sapiens
• Alignment Length: 1244
• Identity: 246/1244 - (19%)
• Similarity: 427/1244 - (34%)
• Gaps: 343/1244 - (27%)

  Fly     4 PKMQIH---PTKMEEDSDTRNSTYVPKMELLMTHYIHEGKKAIMYRSSEPQIA------ARRNKK 59
            |.:..|   |...||.....|...:|..:   :|.:.||       ::.|||:      .||.|.
Human   265 PNLANHKMPPAAAEETPPYSNYNTLPCRK---SHCLSEG-------ATNPQISHSNSMQGRRAKT 319

  Fly    60 TRFV--------------GNRRQLRNLSQPENSHKTSRSLCPDTAKTEPKVYSLRFVLNKSEDKD 110
            |:.|              |.......||:..|:  |:.|..|.|.:.        ||.:.|....
Human   320 TQDVNAGEGSEFADSGIEGATTDTDLLSRRSNA--TNSSYSPTTGRA--------FVGSDSGSSS 374

  Fly   111 Y--MSRLKAQNDFSQSSCLCNNLSHANTEAGAYQND----GILKGQRDHSDFLTAAGGIQSRADR 169
            .  .:|.....:|.:...:....|.:..|||:..:|    |.|.........||||.|...:|..
Human   375 TGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGA 439

  Fly   170 IA-----------RIETC--------------------------GIRTTHLQP-----ETQILKP 192
            :|           ::|:.                          ||....:..     |..|::.
Human   440 LAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQA 504

  Fly   193 VTEPNETRF-----DQHSPDWLFKNSRIGDVSN--SSKLSACNSELPPEEYKGRTLYHDTKFDCA 250
            |.|..:..|     :.....:||:.:...::.|  ::..|||.:.:....:|..||    :...:
Human   505 VPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTL----RLLKS 565

  Fly   251 YIKNRRPLITTESKM---------SITEAEHPQTKYTDI-KYDYKTCSISQGLHQNKAFL----- 300
            .||.....|..:.||         |:|:::..:|....| .::.........|.:.:.:|
Human   566 EIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQG 630

  Fly   301 NKVPPSKQ-----SKP---------------FHSV------DYDYYENIQKLHLSKESERQIRDN 339
            .::|..|:     |:|               ||::      :.......|.:..| .|:|:.|.:
Human   631 GELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRS-ASKRRSRFS 694

  Fly   340 ---GDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDL---NIKEED------HTS 392
               |    |....||...:.:.|::.....::.||   .||...:|:   ..:|::      |..
Human   695 SLWG----LDTTSKKKQGRPSINQVFGEGTEAVKK---SLEGIFDDIVPDGKREKEVVLPNVHQH 752

  Fly   393 NDSGNSYKNDPYLVSMSKINSCKFIRSYNRDCETIFPTG----------------DHSDLNEFRK 441
            |...:.:.::.:..|.       |....|:...|:...|                ||| .:..|.
Human   753 NPDCDIWVHEYFTPSW-------FCLPNNQPALTVVRPGDTARDTLELICKTHQLDHS-AHYLRL 809

  Fly   442 SFM------------------------------PQSVDLLSSASV------SLSSCD-------- 462
            .|:                              .||:.:..|.:.      ||||.:
Human   810 KFLIENKMQLYVPQPEEDIYELLYKEIEICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLY 874

  Fly   463 -------GSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLT 520
                   |....|....|.|  ..|.|.....|...:.| ||.|:....|:...| |.:..|.:
Human   875 VNSVKETGLASKKGLKAGDE--ILEINNRAADALNSSML-KDFLSQPSLGLLVRT-YPELEEGV- 934

  Fly   521 SSCCCSGSFCDD-----DGCSYLDEGLSVDIKSKNVQSL-HESGTDEKLSRKTILLARTE----D 575
                   ...:.     ||.:.|.|.....:.|....|| .|.|:..:.:.:     .||    :
Human   935 -------ELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAETAPE-----ETEGPDLE 987

  Fly   576 TNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQD---PEMQRHRR-------GHILKELFETE 630
            ::|.|...|..|..........|....::....|||   |::...|:       ..::.||.|||
Human   988 SSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETE 1052

  Fly   631 KIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVT---- 691
            :.||.::..:::.|   ||..:......|.:.:||||||.|:..|..: |||.||:.:.:.
Human  1053 RTYVKDLNCLMERY---LKPLQKETFLTQDELDVLFGNLTEMVEFQVE-FLKTLEDGVRLVPDLE 1113

  Fly   692 --ERV----------ALCFVKRRDKFYQLYSFYCQNIQRSEK-LRETLVDT--HMFFKECQIGLG 741
              |:|          ...|:...|:| :|||.:|.:..:..| |.:...||  ..|.........
Human  1114 KLEKVDQFKKVLFSLGGSFLYYADRF-KLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQ 1177

  Fly   742 HKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRN-ELKNALDCMLIVLKCVND--SMHQISI 803
            |...|.:||:||:|||.||.|||::|...||.:|..: .|..|:..|..|...:|:  .:|:...
Human  1178 HSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFG 1242

  Fly   804 TGFSGDLAKQ------------GELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQT 856
            ..|...:|:|            |:||:..:. :|:.....:....|......|:::.:::|.
Human  1243 AVFDQLIAEQTGEKKEVADLSMGDLLLHTTV-IWLNPPASLGKWKKEPELAAFVFKTAVVLV--- 1303

  Fly   857 SKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRV 921
                |...|.|.|..|...::.:.|  ..|..||.         :.:....:.|:.:..|:.:..
Human  1304 ----YKDGSKQKKKLVGSHRLSIYE--DWDPFRFR---------HMIPTEALQVRALASADAEAN 1353

  Fly   922 LFNQLEKLKGDQIAR-YNIRHQSLWQKSSCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKTC 985
            ...::..:|.:...| ..:.|      ..|.:|......|:.....   |.|.:|...:::|...
Human  1354 AVCEIVHVKSESEGRPERVFH------LCCSSPESRKDFLKAVHSI---LRDKHRRQLLKTESLP 1409

  Fly   986 LSDQNIVNG 994
            .|.|.:..|
Human  1410 SSQQYVPFG 1418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	60/193 (31%)
		PH-like	802..925	CDD:473070	21/134 (16%)
TIAM1	NP_003244.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..379		21/97 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..422		7/28 (25%)
		PH1_Tiam1_2	432..558	CDD:269937	18/125 (14%)
		Tiam_CC_Ex	572..669	CDD:408184	15/96 (16%)
		Ubl1_cv_Nsp3_N-like	766..832	CDD:475130	10/73 (14%)
		PDZ	858..>901	CDD:214570	10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..1034		20/99 (20%)
		RhoGEF	1044..1233	CDD:214619	60/193 (31%)
		PH2_Tiam1_2	1235..1406	CDD:269957	31/198 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1456..1482