Protein Alignment CG30440 and Plekhg1

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_001177928.1
• Gene: Plekhg1 / 679812
• RGDID: 1583676
• Length: 1380
• Species: Rattus norvegicus
• Alignment Length: 509
• Identity: 129/509 - (25%)
• Similarity: 224/509 - (44%)
• Gaps: 98/509 - (19%)

  Fly   575 DTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIAS 639
            |||...|..:|..|                      .|::....|  :::|:.|||:.||.::.|
  Rat    93 DTNGTPQTTADSAT----------------------SPKLLYVDR--VVQEILETERTYVQDLKS 133

  Fly   640 ILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDK 704
            |::.|...::.....|...:.:| .||||:.:||.|:::: |::||||.:....:|.|||.:.::
  Rat   134 IVEDYLACIRDQTKLPLGTEDRA-ALFGNIQDIYHFNSEL-LQELENCENDPVAIAECFVSKSEE 196

  Fly   705 FYQLYSFYCQNIQRS-----EKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLL 764
            |: :|:.||.|..||     |.:|..::  ..||:|.|..|.|.||||:|||||||||.||.|||
  Rat   197 FH-IYTQYCTNYPRSVAVLTECMRNKML--AKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLL 258

  Fly   765 KDLLLFTDNDS-CRNELKNALDCMLIVLKCVNDSMH-----------QISITGFSG-DLAKQGEL 816
            .::....|.|: ..:.:.:|:|.|..|...:||...           |..:|.:.| ||...|||
  Rat   259 HEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGEL 323

  Fly   817 LMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSSYQFKSDVKMSQIGLTE 881
            :::.:|          |::.....|.:||..|.||:.|:      .:.::.:|:.:....:.|.|
  Rat   324 VLEGTF----------RIQRAKNERTLFLLDKLLLITKK------REDTFTYKAHILCGNLMLVE 372

  Fly   882 SVSGDAKRFEVW-LKGRQEVYTLQASTIGVKEMWVAEIKR-VLFNQLEKLKGDQIARYNIRHQSL 944
            .:..:...|.|: .|..:..:|:||.:...|.:|:..:|| :|.|...|:...       ..|::
  Rat   373 VIPKEPLSFSVFHYKSPKLQHTVQAKSQQEKRLWILHLKRLILENHAAKIPAK-------AKQAI 430

  Fly   945 WQKSSCEAPNITHCSLRRTECFE------LPLNDSNRNTNIRSEKTCLSDQNIVNGPSVQD---- 999
            .:..:...|..         |::      .|...:......:||.:..|.:.:....:.||
  Rat   431 LEMDAIHHPGF---------CYDPKGEVKTPCGSAPHRLRRKSEPSSRSHKVLKTSETAQDIQKV 486

  Fly  1000 QHEKNSWSSDCSDIDEDETINP------ILMQKTGQPKLLWNRSSSHQVFIKSK 1047
            ..|::| |...|.:.......|      .:::..|..:.||......|.|..|:
  Rat   487 SREESS-SQLTSAVPAQRNRQPGNAAVLNMLRGGGSVRGLWMDHHIQQPFFPSR 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	66/179 (37%)
		PH-like	802..925	CDD:473070	30/125 (24%)
Plekhg1	NP_001177928.1	RhoGEF	116..290	CDD:459876	66/178 (37%)
		PH_PLEKHG1_G2_G3	272..417	CDD:270063	37/160 (23%)