Protein Alignment CG30440 and Vav3

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_001365916.1
• Gene: Vav3 / 57257
• MGIID: 1888518
• Length: 875
• Species: Mus musculus
• Alignment Length: 626
• Identity: 128/626 - (20%)
• Similarity: 240/626 - (38%)
• Gaps: 168/626 - (26%)

  Fly   530 CDDDGC--SYLDEGLSV-DIK--SKNVQSLHESGTDEKLSRKTILLAR------TEDT---NDVT 580
            ||..|.  |.|.|...: |::  .|.:::|      .:|||..|.||.      ||::   .|:.
Mouse    83 CDTFGMRKSELFEAFDLFDVRDFGKVIETL------SRLSRTPIALATGIRPFPTEESINDEDIY 141

  Fly   581 QGISDGTTYFTGSLNITHLPKSNEIF-------------------KKPQDPEMQRHR-RGHILKE 625
            :|:.|       .::.|.:....:::                   ::.|.|:.|.:. |...|.|
Mouse   142 KGLPD-------LIDETRVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAQQPKSQENDIRSCCLAE 199

  Fly   626 LFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEI--------YSFHNDVFLK 682
            :.:||:.|...:.||.|.:...||...:|     .:.:.:|.|:.::        ...|:.:..|
Mouse   200 IRQTEEKYTETLESIEKYFMAPLKRFLTA-----AEFDSVFINIPDLVKVHRSLMQEIHDSIVNK 259

  Fly   683 DLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRS----EKLRETLVDTHMFFKECQIGLGH- 742
            |.:|...|       |:..:::.. :|..||..::.:    :.:.:|..|..:..:||.....:
Mouse   260 DDQNLYQV-------FINYKERLV-IYGQYCSGVESAISNLDYISKTKEDVKLKLEECSKRANNG 316

  Fly   743 KLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFS 807
            |..|...|:.|:||:.||.|||::|:..|.:...:..||.|||.|..:.:.||
Mouse   317 KFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKANLKLALDAMKDLAQYVN------------ 369

  Fly   808 GDLAKQGELLMQ-DSFQVWIESKK-------------DIRLRMKPK----RRHIFLYQKSLLLCK 854
             ::.:..|.|.: ..||:.||:..             :||:....|    .|||||:..::::||
Mouse   370 -EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCK 433

  Fly   855 QTSKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYT-------LQASTIGVKE 912
               :.|.|   |:.|..:.:.|..:..:.:.| |..:.|..|...::|       ....|..:|:
Mouse   434 ---RKGDN---YEMKEIIDLQQYKIANNPTTD-KENKKWSYGFYLIHTQGQNGLEFYCKTKDLKK 491

  Fly   913 MWVAEIKRVLFNQLEKLKGDQIAR--YNIRHQSLWQKSSCEAPNITHCSLRRT-----ECFELPL 970
            .|:.:.:..|.|    ::.|....  ::.:..:..:.:||   .:....||.|     .||:
Mouse   492 KWLEQFEMALSN----IRPDYADSNFHDFKMHTFTRVTSC---RVCQMLLRGTFYQGYLCFK--- 546

  Fly   971 NDSNRNTNIRSEKTCLSD-------QNIVNGPSVQDQHEKNSWSSDCSDIDEDETINPILMQKTG 1028
                  ...::.|.||..       .::..||....:...|........:|.......::...||
Mouse   547 ------CGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTG 605

  Fly  1029 QP------------------KLLWNRSSSHQVFIKSKYILS 1051
            .|                  :||  |..:|.||.:.:.:.|
Mouse   606 TPAPGLHEGPPLHIQAGDTVELL--RGDAHSVFWQGRNLAS 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	46/186 (25%)
		PH-like	802..925	CDD:473070	30/147 (20%)
Vav3	NP_001365916.1	CH_VAV3	2..118	CDD:409113	11/40 (28%)
		RhoGEF	193..369	CDD:238091	46/188 (24%)
		PH_Vav	383..506	CDD:269930	29/133 (22%)
		C1_VAV3	506..564	CDD:410419	11/69 (16%)
		SH3_VAV3_1	596..657	CDD:212914	10/51 (20%)
		SH2_Vav3	666..768	CDD:198270
		SH3_VAV3_2	819..874	CDD:212911