DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and arhgef25b

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_005166148.2	Gene:	arhgef25b / 569561	ZFINID:	ZDB-GENE-080225-17	Length:	625	Species:	Danio rerio

Alignment Length:	708	Identity:	177/708 - (25%)
Similarity:	307/708 - (43%)	Gaps:	149/708 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 KNLIK--ATTNELLKAAAQSTKKCNIDLERKLNDLN----IKEEDHTSNDSGNSYKNDPYLVSMS 409
            |:|.|  ..|.:||.:.:.:.....::.::.:.:.|    :.||....:..|...:|:.
Zfish     2 KSLAKLQGNTEQLLMSLSNTLPSLTLNNQQWIQEQNEGCLLLEEKQGCSKKGAGPENEK------ 60

  Fly   410 KINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQ--------SVDLLSSASVS----LSSCD 462
                    :|:|:..|.|....|...|.......:|.        |.|.||..|.|    .||..
Zfish    61 --------KSWNQRLERIPEDKDSYTLTGLSDVSLPPDDPPSASVSTDDLSPISPSNHQLFSSRR 117

  Fly   463 GSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSG 527
            .|..:..||...:         :.:::|...||....|..:.                     |.
Zfish   118 ASVTSTRSIKAFK---------RWLSSPVRRLSLGGGNKSQS---------------------SK 152

  Fly   528 SFCDDDGCSYLDEGLSVDIKSKNVQS-LHESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFT 591
            .....:|.:|:...||      ..|| |......:||:|.    .|:.|..::::..|..:.|:.
Zfish   153 GIQSPEGSTYMFLPLS------PAQSPLSPMEKSQKLTRS----YRSLDCGELSRETSPDSPYYP 207

  Fly   592 GSLNITHLPKSNEIFKKPQDPEMQ-----------------------RHRRG------HILKELF 627
            ..|        |::|::.|..::|                       :|||.      ::|.||.
Zfish   208 RYL--------NDLFQRNQSFDVQTSVSPSLTDKTLVEQSQSLEDNEQHRRTALEKSIYVLTELV 264

  Fly   628 ETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTE 692
            ||||:||.::..:::||...::| ...|..|:||..::|||:::||.:|.|.||.:||.|:|..:
Zfish   265 ETEKLYVEDLGLVVEGYMLTMRS-VGVPEYLEGKDKIVFGNIHQIYDWHKDYFLGELEKCVSEPD 328

  Fly   693 RVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRI 757
            .:|..|:| .::...:|..||||:.:||.:....::|  :|::.:..|||:|.|...|:||||||
Zfish   329 LLAQLFIK-HERRLNMYVVYCQNMPKSEHIVSEYIET--YFEDLRQQLGHRLQLNDLLIKPVQRI 390

  Fly   758 TKYQLLLKDLL-LFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDS 821
            .||||||||.| .:|.......:|:.|::.|..|.|..||.|:...:.||.|.|..||:||.||:
Zfish   391 MKYQLLLKDFLKYYTKAGRQTEDLERAVEVMCFVPKRCNDMMNVGRLQGFEGQLRAQGKLLQQDT 455

  Fly   822 FQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCK-QTSKSGYNKSSYQFKSDVKMSQIGLTESVSG 885
            | .:||::..|..|  ||.|.:||:::.::|.: ...|.|::...|.:|:.:|:|.:.:.:....
Zfish   456 F-TFIENENSILSR--PKERRVFLFEQLIILSEPMDRKRGFSLPGYVYKNSIKISCLSIEDRCPE 517

  Fly   886 DAKRFEVW---LKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQ----IARYNIRHQS 943
            |..|..:.   :.|..:.:.|:||:..::..|..:|.::|..|...|...|    ..|..|:..|
Zfish   518 DPCRLVLTSRNIDGSLQKFILRASSSEIRTSWANDIIQMLETQRNFLNALQSPIEFQRKEIKSLS 582

  Fly   944 LWQKSSCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKTCLSDQNIVNGPSVQDQH 1001
            |.:..:..|                     :.|:.:|...:...|:..:  |.:|..|
Zfish   583 LGKSMTASA---------------------SLNSGLRPYSSASIDRQTL--PCLQSWH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	68/174 (39%)
		PH-like	802..925	CDD:302622	36/126 (29%)
		PH	829..922	CDD:278594	22/96 (23%)
arhgef25b	XP_005166148.2	RhoGEF	258..429	CDD:238091	68/174 (39%)
arhgef25b	XP_005166148.2	PH-like	434..573	CDD:327399	39/141 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810