DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and LOC559907

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_009303604.1	Gene:	LOC559907 / 559907	-ID:	-	Length:	1046	Species:	Danio rerio

Alignment Length:	1017	Identity:	287/1017 - (28%)
Similarity:	436/1017 - (42%)	Gaps:	285/1017 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 ILKPVTEPNET------RFDQHSPDWLFKNSRIGDVSNSSKLSACNSELPPEEYKG--------- 238
            :::|.|.|..|      ||.|  .|:..|...|...|.|..|...:......|:.|
Zfish    29 VVRPKTHPQTTGTDLGFRFSQ--DDFALKMPMIMLSSLSDLLRFIDENQLSTEFGGSLEQCHSDW 91

  Fly   239 ---RTLYHDTKFDCAYIKNRRPLITTESKMSITEAEHPQ-------------TKYTDIKYDYKTC 287
               ||...........|........||    ::|.|.|.             .||..:|.|.::.
Zfish    92 IVLRTAIESFAVTVKEIAQLLQTFGTE----LSEIELPDDASGIEYLLRSHTEKYRQMKDDIRSV 152

  Fly   288 SISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENIQKLHLSKESER------QIRDNGDPND-- 344
                 :.:.:..|:.:..||..:...:.|.|         :|::.||      |:||.....|
Zfish   153 -----MREGRQLLSNLEASKAVEGAAAEDRD---------ISQDKERVQRLVAQLRDMEMAFDGF 203

  Fly   345 -------LQNFL-----------------KKNLIK----------ATTNELLK------------ 363
                   ||.:|                 |.|:.:          |.|.:|||
Zfish   204 FEKHHLKLQQYLQLLQYELSFHEMEAILEKLNIQEKAIASVGTTVAQTEQLLKDLEMLENTAEDE 268

  Fly   364 --------------------AAAQSTKKCN------------IDLER----KLNDLNIK-EEDHT 391
                                |.|...::||            :..:|    ::.||.:: ||...
Zfish   269 MGRAQIIILHGHQLAASHHYALALIVQRCNELRHHCDTLTTALRAKRASLTRIRDLLLRLEETVR 333

  Fly   392 SNDSGNSYKNDPYLVS---MSKINSCKFIRSYNRDCETIFPTGD---HSDLN----EFRKSFMPQ 446
            ..|.|      .||::   :.|..|.:..::..||.||:..|..   .|:|:    ||:....||
Zfish   334 WCDEG------AYLLANQLLDKFQSKEGAQAALRDIETLMETAPSVLRSNLDILNLEFQAVLTPQ 392

  Fly   447 SVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTE 511
            ....:.|.:..:|:..|...::.:......| .:....|.:|..|.
Zfish   393 LQSQIESVTEKVSTVQGMIQSRQACLRKLAD-IQVRPIQLVAPRPE------------------- 437

  Fly   512 YDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLARTEDT 576
                    ||..|.|..|....         |.|:.|....|...:...:|.|||.....:.|..
Zfish   438 --------TSPRCKSPLFSPKH---------SFDVNSSLRFSFDLALPGKKASRKGPNTKKIEVM 485

  Fly   577 NDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIASIL 641
            :|..:..|          .:::.|:..|      :|:..:.|   ::|||.|||:|||.|:.|:|
Zfish   486 HDYEENRS----------CLSYGPEGVE------NPDQHKRR---VMKELIETERIYVEELMSVL 531

  Fly   642 KGYYDRLKSDESA-----PASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKR 701
            .||  |.:.|..|     |:.|:.|...|||||.|||.||:.:||:|||:|:...|||...|::|
Zfish   532 LGY--RAEMDNPALSNILPSVLRNKKEDLFGNLPEIYKFHSRIFLQDLESCLETPERVGARFLER 594

  Fly   702 RDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKD 766
            ::.| |:|..||||..||:.|.....|: .|.:||:..|.|||.|.:||||||||:||||||||:
Zfish   595 KEHF-QVYERYCQNKPRSDALWRQCSDS-AFIQECKGKLDHKLGLDSYLLKPVQRLTKYQLLLKE 657

  Fly   767 LLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESK-- 829
            ||..:.|....:||:.||:.||.:||.||||||||||||:.|:|:..|.:|||.||.|||..|
Zfish   658 LLKHSSNSQYASELQGALNAMLDLLKSVNDSMHQISITGYEGELSDLGRVLMQGSFNVWINHKKG 722

  Fly   830 ----KDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGY---NKSSYQFKSDVKMSQIGLTESVSGDA 887
                ||: .|.||.:||:||::::||.||:..::|.   ..:||.||..:.||.:|:||:|.||.
Zfish   723 PTRMKDM-ARFKPMQRHLFLHERALLFCKKREETGEGHDRTASYSFKHCLMMSAVGITENVKGDV 786

  Fly   888 KRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQ-----------IARYNIRH 941
            |:||:|..|::|||.:||.|:.||..|:.||:::|.||.:.:|||.           :|. ::||
Zfish   787 KKFEIWYNGKEEVYVVQAPTVDVKIAWLTEIRKILNNQQKTVKGDSQPDREQPLSPPLAD-SVRH 850

  Fly   942 QSL---WQKSSCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKT-------CLSDQNIVNGPS 996
            .|:   |     .|..||.||    .||::..:..::..::.||:.       .|:|..|:: |.
Zfish   851 ISVCMPW-----SATQITGCS----GCFDVLPHSKHQGASVSSEEADSGRVSPVLTDPVIIS-PR 905

  Fly   997 VQDQHEKNSWS-------------------SDCSDIDEDETI 1019
            .:: |.:.||.                   |:.||.||::.:
Zfish   906 PRN-HNRRSWPGTSHSVDICEGLEDWTTDLSNISDSDEEDDV 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	88/178 (49%)
		PH-like	802..925	CDD:302622	59/131 (45%)
		PH	829..922	CDD:278594	43/101 (43%)
LOC559907	XP_009303604.1	SEC14	<20..85	CDD:326643	15/57 (26%)
		SPEC	119..318	CDD:321951	34/212 (16%)
		SPEC	224..415	CDD:238103	36/196 (18%)
		RhoGEF	509..686	CDD:238091	88/183 (48%)
		PH-like	693..824	CDD:327399	59/131 (45%)
		SH3	952..1005	CDD:327375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm24801
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	LDO	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910