Protein Alignment CG30440 and vav2

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_017208431.2
• Gene: vav2 / 556413
• ZFINID: ZDB-GENE-091204-420
• Length: 880
• Species: Danio rerio
• Alignment Length: 664
• Identity: 133/664 - (20%)
• Similarity: 244/664 - (36%)
• Gaps: 196/664 - (29%)

  Fly   375 DLERKLND-LNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCKFIRSYNRDC--------ETIFPT 430
            ||.:.|.| :.:.:..|..:......|...:...||:....|.||::.:.|        ..:|..
Zfish    32 DLAQALRDGVLLCQMLHNLSPGSVDLKQINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDP 96

  Fly   431 GDHSDLNEFRKSFMPQSVDLLSSAS-VSLSSCDG--------SCLNKDSICGS------EEDCCE 480
            .|..|:.:|.|     .:..||..| .|::...|        :.||:|.:..|      |.|..|
Zfish    97 FDLFDVRDFGK-----VISALSRISHNSIAQIKGIRPFPSEDTALNEDDVYRSLEELADEHDVGE 156

  Fly   481 CNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVD 545
            .:.|.|:.                                         |:|||....::.:.|:
Zfish   157 DDIYDCVP-----------------------------------------CEDDGDDIYEDIIKVE 180

  Fly   546 IKSKNVQSLHESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQ 610
            ::...::.:.:.|             .|||
Zfish   181 VRQPMIRYMQKMG-------------MTED----------------------------------- 197

  Fly   611 DPEMQRHRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSF 675
                  .:|...|.|:.|||..|...:..|.|.|...|| ....|..::    .:|.||.:|...
Zfish   198 ------DKRNCCLVEIQETEAKYYKTLEDIEKNYMIPLK-QVLTPQEME----AIFVNLEDIIRV 251

  Fly   676 HNDVFLKDLE-NCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFK----E 735
            | ...|:.:: ..:|....:...|:..:::.. :|..||.:::.::|..:.|:.|....|    |
Zfish   252 H-FALLRAIDLTMVSGGNGLGKIFLDFKERLL-IYGQYCSHMENAQKTLDELIATREDVKCKVEE 314

  Fly   736 CQIGLGH-KLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVND--- 796
            |.:.:.. |..|...|:.|:||:.||.||||:|:..:.:...|.:||.||:.|..:...:|:
Zfish   315 CTMKVQEGKFKLQDLLVVPMQRVLKYHLLLKELVSHSMDRPERQQLKEALEAMQDLAMYINEVKR 379

  Fly   797 --------SMHQISITGFSGDLAKQGELLMQDSFQVWI---ESKKDIRLRMKPKRRHIFLYQKSL 850
                    |..|.||......|.:.|...:....:|..   .:|:|         |:|||:.|.:
Zfish   380 DNETLKKISEFQSSIENLQVKLEEYGRPKIDGELKVCSIVNRTKQD---------RYIFLFDKVV 435

  Fly   851 LLCKQTSKSGYNKSSYQFKSDVKMSQIGLTESV--SGDAKRF--EVW--------LKGRQEVYTL 903
            ::||   :.|||   |:.|..:::....:::..  :.|.|:.  ::|        |:|:|. :..
Zfish   436 IVCK---RKGYN---YELKEVIELHLYKMSDDPMNNRDMKKSSGKMWSYGFYLIHLQGKQG-FQF 493

  Fly   904 QASTIGVKEMWVAEIKRVLFN-QLEKLKGDQIARYNIRHQSLWQKSSCEAPNIT---------HC 958
            ...|...|..|:.:.:..:.| :.|:...:|   :|.:..:..:.::|.|..:.         :|
Zfish   494 FCKTEDTKRKWMEQFEMAMSNIKPERATANQ---HNFQMHTFEKNTNCRACKMLLRGIFYQGYYC 555

  Fly   959 SLRRT----ECFEL 968
            ||..|    ||.|:
Zfish   556 SLCGTGAHKECLEI 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	48/179 (27%)
		PH-like	802..925	CDD:473070	29/138 (21%)
vav2	XP_017208431.2	None