DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30440 and Arhgef25

DIOPT Version :10

Sequence 1:NP_610172.1 Gene:CG30440 / 35496 FlyBaseID:FBgn0050440 Length:1057 Species:Drosophila melanogaster
Sequence 2:NP_082303.2 Gene:Arhgef25 / 52666 MGIID:1277173 Length:618 Species:Mus musculus


Alignment Length:504 Identity:150/504 - (29%)
Similarity:241/504 - (47%) Gaps:79/504 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   474 SEEDCCE-----CNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSG------ 527
            :|.||.|     ..|.:.:|..|...|...  ||.||..             |:...||      
Mouse    47 TESDCIEEDQTGQREPEVLAWAPQPESYSI--AVSEGSM-------------SASAVSGLAALSG 96

  Fly   528 --SFCDDDGCSYLDEGLSVDIK-----SK---NVQSLHESG---------------TDEKLSRKT 567
              |....|.||.:..|....::     ||   :|::..|||               |.::|...|
Mouse    97 PSSGLSSDPCSPIPPGPVTGLRRWLDHSKHCLSVETEAESGQTGQCENWTLEPTLTTGQELPELT 161

  Fly   568 ILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKI 632
            :|....|...|..|...:.|        ::..||:.|..||     |...|...:|.||.|||:.
Mouse   162 LLTTLLEGPGDKAQPAEEET--------LSQAPKNEEEQKK-----MALERSMFVLGELVETERT 213

  Fly   633 YVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALC 697
            ||:::..|::||...: :.:..|.||:|:..::|||:.:||.:|.|.||::|:.|:...:.:|..
Mouse   214 YVDDLGQIVEGYMATM-ATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPDWLAQL 277

  Fly   698 FVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQL 762
            |:|...:.: :|..||||..:||.:.....|:  :|:|.:..|||:|.|...|:||||||.||||
Mouse   278 FIKHERRLH-MYVVYCQNKPKSEHVLSEFGDS--YFEELRQQLGHRLQLNDLLIKPVQRIMKYQL 339

  Fly   763 LLKDLLLF---TDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQV 824
            ||||.|.:   ...|:  .||:.|::.|..|.|..||.|....:.||.|.|..||:||.||:|.|
Mouse   340 LLKDFLKYYRRAGKDT--EELEQAVEVMCFVPKRCNDMMSLGRLRGFEGKLTAQGKLLGQDTFLV 402

  Fly   825 WIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYN--KSSYQFKSDVKMSQIGLTESVSGDA 887
             .|.:....|..:.:.|.:||:::.::..:.....|..  :..|.:|:.:|:|.:||..::.|:.
Mouse   403 -TEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGGRGGAQPGYVYKNSIKVSCLGLEGNLQGNP 466

  Fly   888 KRFEVWLKGRQ---EVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQ 933
            .||.:..:|.:   :.|.||||...|.:.|:.::.::|.:|.:.|...|
Mouse   467 CRFALTSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILESQRDFLNALQ 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30440NP_610172.1 RhoGEF 622..796 CDD:214619 67/176 (38%)
PH-like 802..925 CDD:473070 36/127 (28%)
Arhgef25NP_082303.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..63 5/15 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..193 6/31 (19%)
RhoGEF 203..373 CDD:459876 67/175 (38%)
Important for binding to Rho GTPases. /evidence=ECO:0000250 317..338 13/20 (65%)
PH2_Kalirin_Trio_p63RhoGEF 378..520 CDD:270061 39/139 (28%)
Sufficient to bind activated GNAQ. /evidence=ECO:0000250 506..532 3/10 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..604
Blue background indicates that the domain is not in the aligned region.

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