Protein Alignment CG30440 and trio

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Alignment Length: 1071
• Identity: 266/1071 - (24%)
• Similarity: 427/1071 - (39%)
• Gaps: 289/1071 - (26%)

  Fly    45 YRSSEPQIAARRNKKTRFVGNR-----RQLRNLSQP-ENSHKTSRSLCPDTAKTEPKVYSLRFVL 103
            |:.:| |:....|:....:.|.     :|.::|.|. ||:...|.:....||:...: |.|.|:.
  Fly   813 YQKAE-QLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIE-YLLDFLR 875

  Fly   104 NKSEDKDYMSRLKAQNDFSQSSCLCNNLSHANTEAGAYQNDG--ILKGQRDHSDFLTAA----GG 162
            .:..|.:.||..| :....|:..||.           :|||.  ::...|:....|.|:    ..
  Fly   876 EREIDLEEMSEAK-RAKLEQAVQLCQ-----------FQNDANQVISWIRNGEAMLVASFVTPNS 928

  Fly   163 IQSRADRIARIETCGIRTTHLQPETQILKPVTEPNETRFDQHSPDWLFKNSRIGDVSNSSKLSAC 227
            :|         |...:|..|.|.:..|.|..|...:.:
  Fly   929 LQ---------EAEQLRKGHEQFQIAIEKTHTSAVQVK--------------------------- 957

  Fly   228 NSELPPEEYKGRTLYHDTKFDCAYIKNRRPLITTESKMSITEAEHPQTKYTDIKYDYKT----CS 288
                    |:...|.:...:|...|......:|.:.:..:|.||......|.....|||    ||
  Fly   958 --------YRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCS 1014

  Fly   289 ISQGLHQNKAFLNKVPPSKQSKPFHSVDY-------------DYYENIQKLHLSKESERQIRDNG 340
            :...|.:                    :|             |..:.|.:| :||..|::
  Fly  1015 VLDSLER--------------------EYKREDDWCDGGGGSDKAQAIVQL-ISKHQEQK----- 1053

  Fly   341 DPNDLQNFLKK-NLIKATTNELLKAAAQSTK------KCNIDLERKLNDLNIKEEDHTSNDSGNS 398
                 :.|||. .|.:.|....||.|.:|.:      .|...::.||:.|..:|....
  Fly  1054 -----EAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVL------- 1106

  Fly   399 YKNDPYLVSMSKINSCK----FIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSAS--VS 457
               |.:.:....::.|:    |.||..:..|.|..||:                ..|||.|  |.
  Fly  1107 ---DYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGE----------------AYLSSRSNLVG 1152

  Fly   458 LSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSK------DCLNAVEEG----------- 505
            :|..:...|.|           |.||::..|....|..|      |.|  ||:|
  Fly  1153 ISKEETEGLLK-----------EHNEFRSTAKETRERVKLLIQLADSL--VEKGHAHASDIKQWV 1204

  Fly   506 VFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILL 570
            ...:..|.||...:            |..|..|::.|.                   :|::.:||
  Fly  1205 ASVDQRYKDFSNRM------------DSYCEQLEKSLG-------------------MSQQQLLL 1238

  Fly   571 ARTEDTNDVTQGISDGTTYFTGSLNITH--------LPKSNEIFKKPQDPEMQRHRRGH-ILKEL 626
            .            |||.:..:.|....|        |..||:..|:..:.:.:..||.. |:.||
  Fly  1239 G------------SDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAEL 1291

  Fly   627 FETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVT 691
            .:||:.|||::|:.:|.:.:..::.:|.|::|.|:.:|:|||:.||:.||..:||::||...::.
  Fly  1292 MQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMP 1356

  Fly   692 ERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTH--MFFKECQIGLGHKLPLGAYLLKPV 754
            |.|..|||....|| .:|..||:|...|..|   ||. |  .||:|.|..|....||.|||:|||
  Fly  1357 EDVGHCFVTWASKF-DMYVHYCKNKPTSNNL---LVQ-HGGSFFEELQRRLEVDHPLPAYLIKPV 1416

  Fly   755 QRITKYQLLLKDLLLFTDNDSC----RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGE 815
            ||||||||||||||      ||    ..|:|..|:.||.|.|..||:||...:......:.|.||
  Fly  1417 QRITKYQLLLKDLL------SCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGE 1475

  Fly   816 LLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSSYQFKSDVKMSQIGLT 880
            :::||:||.| ::|:.||   |.:.|.:||::..||..|:..:|  |...|||||.:..:.:|:|
  Fly  1476 VVLQDAFQAW-DTKQIIR---KGRERRVFLFELYLLFAKEVKES--NVVKYQFKSKLMTTDMGIT 1534

  Fly   881 ESVSGDAKRFEVWLKGRQEVYT-----LQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIA--RYN 938
            |.:.||..:|.|| .||..:.:     |:|:::..|::||.:::.|:  |.....|..:.  :..
  Fly  1535 EHIEGDETKFAVW-TGRSPMLSDCRIVLKATSLETKQIWVKKLREVM--QETCFSGTSLTLPKSP 1596

  Fly   939 IRHQSLWQKSSCEAPNITHCSLRRTECFELPLNDSNRNT--NIRSEKTCLSDQNIVNGPS--VQD 999
            .:|....|:||.:...            :|..||.:|.:  :..|..|..||..:.|..:  |..
  Fly  1597 AKHSGSSQRSSRDLDE------------QLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVA 1649

  Fly  1000 QHEKNSWSSDCSDIDEDETINPILMQKTGQP 1030
            .:...|.|::.| :.:.:.:..:.....|:|
  Fly  1650 DYIATSGSNELS-VSKGQQVEIVEPPTAGEP 1679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	78/179 (44%)
		PH-like	802..925	CDD:302622	41/127 (32%)
		PH	829..922	CDD:278594	32/97 (33%)
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103	45/241 (19%)
		SPEC	897..1119	CDD:238103	53/317 (17%)
		SPEC	1125..1226	CDD:197544	31/141 (22%)
		RhoGEF	1287..1456	CDD:279015	78/179 (44%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	42/130 (32%)
		PH	1495..1580	CDD:278594	28/87 (32%)
		SH3_Kalirin_1	1643..1707	CDD:212786	6/38 (16%)
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462259
Domainoid	1	1.000	62	1.000	Domainoid score	I2478
eggNOG	1	0.900	-	-		E1_KOG0689
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840