DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and sif

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	NP_001261446.1	Gene:	sif / 43892	FlyBaseID:	FBgn0085447	Length:	2734	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	174/902 - (19%)
Similarity:	309/902 - (34%)	Gaps:	286/902 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 SDFLTAAGGIQSRADRIARIETCGIRTTHLQPETQILKPVTEPNETRFDQHSPDWLFKNSRIGDV 218
            ::.|...|..:.|...::| ...|.....:|..::     .||.:| |....||..:....:.|.
  Fly  1102 NNLLAGRGATKRRPPMLSR-SNSGSSRRSMQMNSR-----DEPEKT-FKVAMPDNAYSTVYLRDA 1159

  Fly   219 SNSSKL--SAC-NSELPPEEY----KGRTLYHDTKFDCAYIKNRRPLITTESKMSITEAEHPQTK 276
            .:..:.  ||| ...|.|.|:    |.|....|..:   ::.:|..||  |:.:...|
  Fly  1160 MSVEEFLASACARRNLNPMEHFVRVKKRRDMEDHNY---FVPHRNDLI--ENYLHNHE------- 1212

  Fly   277 YTDI--KYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENIQK-----LHLSKESER 334
            :.::  |..|:.......|.|...|              ||:.:..||.::     .::|:..::
  Fly  1213 FVEVCMKILYQVELQRTTLEQMWGF--------------SVEAELIENAERQDELCCYVSRVEDK 1263

  Fly   335 QIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKEEDHTSNDSGNSY 399
            .:.           :...:||.....::..|..|      ||:....:..::||...|....:|.
  Fly  1264 SVA-----------MHNGIIKGDEIMVINGAIVS------DLDMMYLESVLQEEQSLSMMMRSSR 1311

  Fly   400 KNDPYLVSMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGS 464
            ...|.||.:.::..                                   |::.|........|..
  Fly  1312 TEPPDLVGIMRVTD-----------------------------------DMIDSLVCPPPPTDPP 1341

  Fly   465 CLNKDSICGSEEDCCECNEYQCIATPP--NELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSG 527
            .::::.|.|            .|...|  |..|||..:...|
  Fly  1342 VMSEEMITG------------LIVPAPGWNGTSKDLYSPEAE----------------------- 1371

  Fly   528 SFCDDDGCSYLDE------------------GLSVDIKSKNVQSLHESG---TDEKLSRKTILLA 571
               .....|::|.                  ||.|...:....|.....   |.|:.:||
  Fly  1372 ---SSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRTSSFEIENLLKTAEQETRK----- 1428

  Fly   572 RTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNE 636
             :..|..||..:|  ||..|.|..:|             |.|..|    .::.||.:||:.||..
  Fly  1429 -SSPTGSVTSSVS--TTALTPSRQLT-------------DAEKLR----KVVMELVDTERTYVKH 1473

  Fly   637 IASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVT---ERVALCF 698
            :.::|:.|.:.:|.:....   ..:.|.||||::||.:|... ||::||..:.:.   .:...|.
  Fly  1474 LNNLLEHYLEPMKRETFLS---NAEINALFGNIHEIVTFQRQ-FLQNLEESLDLEPDFNKFEHCG 1534

  Fly   699 VKRRDKF------------YQLYSFYCQNIQRSEKLRETLVDTHM---FFKECQIGLGHKLPLGA 748
            ..|...|            ::|||.:|.:..:::|:.......|.   |.........|...|.:
  Fly  1535 QFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSSTLES 1599

  Fly   749 YLLKPVQRITKYQLLLKDLLLFTDNDSCRN-ELKNALDCMLIVLKCVND---------------- 796
            ||:||:|||.||.|||:.:...||..:..: .|..||..|..|.:.:|:
  Fly  1600 YLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLF 1664

  Fly   797 SMHQISITGFSGDLAKQ------GELLMQDSFQVWI-------ESKKDIRLRMKPKRRHIFLYQK 848
            ..||.|        .||      |:||.....: |:       :.||.:.|...     .|:::.
  Fly  1665 RQHQKS--------CKQPIDLSPGDLLYYGGVE-WLNISDFLGKIKKGLELHAM-----CFVFKS 1715

  Fly   849 SLL-LCKQ-----------TSKSGYNK-SSYQFKSDVKMSQIGLTESVSGDAKRFEVW------- 893
            ::: |||:           :||:..|: ...:::..:.::::.:..|.:.|.....:|
  Fly  1716 AVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRS 1780

  Fly   894 -LKGRQE-VYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQKS 948
             |:.|.| ||.|..||...:..::..|:             ||.|.::|:.|:..|:
  Fly  1781 QLQRRSEKVYVLSNSTADFRNAFLKTIR-------------QIIRESVRNMSIPMKN 1824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	52/192 (27%)
		PH-like	802..925	CDD:302622	29/157 (18%)
		PH	829..922	CDD:278594	22/114 (19%)
sif	NP_001261446.1	WH1	35..144	CDD:214674
		PH1_Tiam1_2	860..985	CDD:269937
		PH	873..974	CDD:278594
		TIAM1_RBD	1141..1219	CDD:176413	19/90 (21%)
		PDZ_signaling	1221..1308	CDD:238492	18/117 (15%)
		RhoGEF	1456..1647	CDD:238091	53/198 (27%)
		PH2_Tiam1_2	1650..1823	CDD:269957	36/199 (18%)
		PH	1693..1812	CDD:278594	24/136 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840