DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and MCF2

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_005262470.1	Gene:	MCF2 / 4168	HGNCID:	6940	Length:	1044	Species:	Homo sapiens

Alignment Length:	1023	Identity:	279/1023 - (27%)
Similarity:	426/1023 - (41%)	Gaps:	261/1023 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 CNSELPPEEYKGRTLYH----------DTKFDCAYIKNRRPLITTESKMSIT----EAEHP---- 273
            ||....|||...:.|.:          |::|  ..|.:||  :.|.|.:.|:    .|..|
Human    68 CNFRCIPEEVIAKVLTYLTSIARQNGSDSRF--TIILDRR--LDTWSSLKISLQKISASFPGNLH 128

  Fly   274 -----------QTKYTDIKYDYKTCSISQGLHQNKAFLNKVP--------------PSKQSKP-- 311
                       |..:|||.:.:          ..:.|:.|:|              ..||..|
Human   129 LVLVLRPTSFLQRTFTDIGFWF----------SQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPEL 183

  Fly   312 ------FHSVDYDYYENIQKLHLS-KESERQIRDNGD-------PNDLQNF------------LK 350
                  .||....:...|:...|: ||..:.::..|.       |:|:.:.            |.
Human   184 GGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLL 248

  Fly   351 KNLIKATTNE---LL--------KAAAQSTKKCNIDLE---RKLNDLNIKEEDHTSNDSG----N 397
            ||.|.|.|.|   ||        :.|..|..:|:..:.   :.:|.|..:..|..:...|    :
Human   249 KNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 313

  Fly   398 SYKNDPYLV-------SMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRK---SFMPQSVDLLS 452
            ..|.:.||.       ....:...:|:  .|:..|....||..:.:.:..|   :....|.:|||
Human   314 QLKMEQYLQLWKFEQDFQQLVTEVEFL--LNQQAELADVTGTIAQVKQKIKKLENLDENSQELLS 376

  Fly   453 SASVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHE 517
            .|...:  ..|..|..:.....:..|..|||.:       .||...:|.::......:.....|:
Human   377 KAQFVI--LHGHKLAANHHYALDLICQRCNELR-------YLSDILVNEIKAKRIQLSRTFKMHK 432

  Fly   518 NLTSSCCCSGSFCDDDGC------------------------SYLDEGL---------------- 542
            .|..:..|    ||:..|                        ::|:..|
Human   433 LLQQARQC----CDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDV 493

  Fly   543 -----------SVDIKSKNVQSLHES------GTDEKLSRKTILLARTEDTNDVTQG-------- 582
                       ::.:|.:|::|:.|:      ...:|..|....:..|.: |.||.|
Human   494 ILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPE-NLVTSGTPFFSSKQ 557

  Fly   583 ISDGTTYF----------------TGSLNITHLPKSNEIFKKPQDPEMQRHR-------RGHILK 624
            :..|.::|                ..:|.|..:|...|  |:...|......       :.|:|.
Human   558 VGVGYSFFQACKLFSKGKKTWRQNQSNLKIEVVPDCQE--KRSSGPSSSLDNGNSLDVLKNHVLN 620

  Fly   625 ELFETEKIYVNEIASILKGYYDRLKSDES---APASLQGKANVLFGNLNEIYSFHNDVFLKDLEN 686
            ||.:||::||.|:.::|.||...:.:.|.   .|..|:.|.::||||:.|||.||||:||..|||
Human   621 ELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLEN 685

  Fly   687 CISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLL 751
            |....|||..||::|:|.| |:|:.||||..|||.:.....:. .||:|||..|.|:|.|.:|||
Human   686 CAHAPERVGPCFLERKDDF-QMYAKYCQNKPRSETIWRKYSEC-AFFQECQRKLKHRLRLDSYLL 748

  Fly   752 KPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGEL 816
            ||||||||||||||:||.::.:......||.|||.||.:||.||||||||:|.|:.|:|.:.|::
Human   749 KPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKM 813

  Fly   817 LMQDSFQVWIESK------KDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKS---SYQFKSDV 872
            :||..|.|||..|      ||: .|.||.:||:|||:|:::.||:..:||....   ||.||...
Human   814 IMQGGFSVWIGHKKGATKMKDL-ARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCW 877

  Fly   873 KMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKL------KG 931
            ||.::|:||.|.||.::||:|...::|||.:|||.:.||..|:.||:.:|..|.|.|      :.
Human   878 KMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQ 942

  Fly   932 DQIARYNIRHQSLWQKS--------SCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKTCLSD 988
            ||:...:....||.|..        |.|...:.|.|.....|..:....:..|| :.:|.:
Human   943 DQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANT-VWTEAS---- 1002

  Fly   989 QNIVNGPSVQDQHEKNSWSSD--CSDIDEDETINPILMQKTGQPKLLW 1034
                  .|.:...|...|||:  ....||:|..|..||:...:..||:
Human  1003 ------QSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	87/176 (49%)
		PH-like	802..925	CDD:302622	54/131 (41%)
		PH	829..922	CDD:278594	42/101 (42%)
MCF2	XP_005262470.1	SEC14	48..188	CDD:214706	26/133 (20%)
		SPEC	328..519	CDD:238103	31/205 (15%)
		RhoGEF	615..792	CDD:238091	87/178 (49%)
		PH-like	799..930	CDD:302622	54/131 (41%)
		PH	842..927	CDD:278594	36/84 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3967
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm40749
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	LDO	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.870