Protein Alignment CG30440 and plekhg4

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_009301619.1
• Gene: plekhg4 / 326099
• ZFINID: ZDB-GENE-030131-4824
• Length: 2630
• Species: Danio rerio
• Alignment Length: 1168
• Identity: 252/1168 - (21%)
• Similarity: 438/1168 - (37%)
• Gaps: 352/1168 - (30%)

  Fly    10 PTKMEEDSDTRNSTYVP---KMELLMTHYIHEGKKAIMYRSSEPQIAARRNKKTRFVGNRRQLRN 71
            ||:.|......:|::|.   ::|.|.:|             .|..::..:|..::       |.:
Zfish  1567 PTEFEGTFPYAHSSWVSFRMRLEQLTSH-------------CEDAVSLLQNTISK-------LES 1611

  Fly    72 LSQPENSHKTSRSLCPDTAKTEPKVYSLRFVLNKSEDKDYMSRLKAQNDFSQSSCLCNNLSHANT 136
            ...|..:.:....||.........:...|.|..:.|....:|||:.:   ..|..|..:...|..
Zfish  1612 TVLPPTAEEAQLLLCKYRELMRTVLEDSRLVRLQLEGGAALSRLRKE---ETSVSLTEDYRDAIE 1673

  Fly   137 EAGAYQND--------------------------GILKGQRDHSDFLTAAGGIQSRADRIARIET 175
            .||...|.                          .:.:|.::.|.::...|  :||...::.:|.
Zfish  1674 SAGRLYNQVDELVHRLVMLSNKCTQELEFIMEFKSLEEGFKEVSQWIEEVG--ESRLQTLSELED 1736

  Fly   176 CGIRTTHLQPETQILKPVTEPNETRFDQH--SPDWLFKN-SRIGDVSNSSKLSACNSELPPEEYK 237
            ...:..|.|       .:.....|...:|  |.:.|.|. .:..|||        ::||...|.|
Zfish  1737 SLEQLHHKQ-------SIFREFYTAAYEHCKSGEALLKRLEKWEDVS--------SAELQVYEVK 1786

  Fly   238 GRTLY----------HDTK------------FDCAY---IKNRRPL---------ITTESKMSIT 268
            .|:.:          .|||            ||.||   ::..|.|         ::.:.:..||
Zfish  1787 VRSFWVHLRDFSQRVEDTKDKIDKTVQLYEFFDKAYEWALEGMRHLACVSMEDCGMSEKCQSVIT 1851

  Fly   269 -----EAEHPQ------TKYTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYEN 322
                 .::||.      .:..|:..:.|:   .|||.|.|...:|...:||          .:|
Zfish  1852 CLETYRSQHPPIPDAHFQEMKDLAGELKS---EQGLKQWKFAWSKCQETKQ----------MFE- 1902

  Fly   323 IQKLHLSKESERQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKE 387
             :||.::..|.|.                               ..:|....|..|:.:|::.|.
Zfish  1903 -KKLEMALRSRRD-------------------------------SDSKSVRSDSSRRNSDVSTKH 1935

  Fly   388 EDHTSNDSGNSYKNDPYLVSMSKINSCK--FIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDL 450
            ::.:|:.|                .||:  |..::.||     ....|
Zfish  1936 QERSSSIS----------------FSCRKAFGGAWGRD-----RLSSH----------------- 1962

  Fly   451 LSSASVSLSSCDGSCLN-KDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDD 514
             ||.|.:.||..|..|: :|:                :.||...     ..::|..:..:|....
Zfish  1963 -SSTSSTPSSPSGIRLDARDT----------------VRTPTGS-----PYSIEHRIPHSTPVRS 2005

  Fly   515 FHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLARTEDT--- 576
              ..||.|..     .|:...|...|||:         |...|||..:.:|:.:...::.||
Zfish  2006 --HRLTRSIS-----TDESPQSPHAEGLA---------STSPSGTSVQTNRRVLRKTQSFDTAGS 2054

  Fly   577 NDVTQ------GISD-----GTTYFTGSLNITHLPKSNEIFKKPQDPEM---------QRHRRG- 620
            ..|:|      .:|:     .|..|...|.::    |.|:..:|..|.:         ..||.|
Zfish  2055 EPVSQYGTCQRTLSEPARRGNTGVFIKGLEVS----STEVIDRPYSPRLPPIHGWSSIDAHRSGS 2115

  Fly   621 -------------HILKELFETEKIYVNEIASILKGYYDRLKSDESA--PASLQGKANVLFGNLN 670
                         ||:.|:..||:.||..:..|:..|:..:   |.|  |..|:||.:|:||||.
Zfish  2116 PAPETRSKGSKLRHIVDEMVTTEREYVRSLRYIIDNYFPEM---ERAVLPQDLRGKRSVIFGNLE 2177

  Fly   671 EIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTH--MFF 733
            ::..||:..|||:||:|.:...||:.||::.:|:| .||:.|.:|..:|    :||:.:|  .||
Zfish  2178 KLVDFHSQYFLKELESCCNHPLRVSHCFLRHQDQF-SLYALYSKNKPKS----DTLLASHGNNFF 2237

  Fly   734 KECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLL--LFTDNDSCRNELKNALDCMLIVLKCVND 796
            |..|:.||.|:.|.:|||||:||::||.||||||:  :....:.....|:.|.:.:...|:..||
Zfish  2238 KHKQMELGDKMDLASYLLKPIQRMSKYALLLKDLIKEVSEVQEQELTYLRAAAEMVKFQLRHGND 2302

  Fly   797 SMHQISITGFSGDLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGY 861
            .:...:|.....:|.:||:|:.||.|.:....||        .:||:||::..:|..|.....|
Zfish  2303 LLAMDAIRDCDVNLKEQGQLVRQDEFTISYGRKK--------CQRHVFLFEDLVLFSKPKRIEG- 2358

  Fly   862 NKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGR---QEVYTLQASTIGVKEMWVAEIKRVLF 923
            ....|.:|...|.:.:|:||:...::.|||:|.:.|   .:.|.||:||..:|..|..:|.|:|:
Zfish  2359 GLDVYIYKHSFKTADVGMTETSGENSLRFEIWFRRRTSKNQTYILQSSTADIKHAWTCDIARILW 2423

  Fly   924 NQLEKLK---------------------------GDQIARYNIRHQSLWQKSSCEAPNITHCSLR 961
            .|..:.|                           .|:...|.::.:....::|.......|.:..
Zfish  2424 QQATRNKEIRMQEMVSMGVGNKPFLDIKPSDAAINDRAIDYIMKGRGARTRASIAVSLFDHSNPF 2488

  Fly   962 RTECFELPLNDS-------------NRNTNIRSEKTCLSDQNIVNGPSVQD---QHEKNSWSS 1008
            :......|::.:             ..|.::.|.::.|:.:..:.||.:::   :||.:|..|
Zfish  2489 KRAAVNTPVSGTPVSGGPSSSTLLGPLNLHMYSSQSLLAGERPLIGPCIEEDELEHETSSQPS 2551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	67/179 (37%)
		PH-like	802..925	CDD:302622	38/125 (30%)
		PH	829..922	CDD:278594	29/95 (31%)
plekhg4	XP_009301619.1	COG5099	467..>912	CDD:227430
		SEC14	1433..1573	CDD:238099	3/5 (60%)
		BAR	<1707..>1807	CDD:299863	24/116 (21%)
		RhoGEF	2130..2302	CDD:279015	67/179 (37%)
		PH_puratrophin-1	2294..2430	CDD:270062	42/144 (29%)
		PH	2319..2414	CDD:278594	32/103 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810