DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and quo

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	NP_001004109.2	Gene:	quo / 321031	ZFINID:	ZDB-GENE-030131-9944	Length:	1987	Species:	Danio rerio

Alignment Length:	983	Identity:	239/983 - (24%)
Similarity:	392/983 - (39%)	Gaps:	211/983 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MTHYIHEGKKAIMYRSSEPQIAARRNKKTRFVGN---RRQLRNLS----QPENSHKTSRSLCPDT 89
            |...:.:.:...:.|.....:|..|.:::||..:   |..|.:::    |.|.|..|.      .
Zfish   943 MKMVLEDTRLVALQREGGAILARMRREESRFAHSEDFRDSLESVTCLYDQVEESVHTL------V 1001

  Fly    90 AKTEPKVYSLRFVLNKSEDKDYMSRLKAQNDFSQSSCLCNNLSHANTEAGAYQND------GILK 148
            .|:...:..|..||...|.:|.:..:       |..|        :.|...:|.|      .:.|
Zfish  1002 MKSNQSLQHLEHVLLLRETQDSLHTI-------QKWC--------DAEERLWQKDKDDAEKTLQK 1051

  Fly   149 GQRDHSDFLTAAGGIQSRADR----IARIETCGIRTTHLQPETQILKPVTEPNETRFDQHSPDWL 209
            .|:...|..|.....:...:|    |..:|... :.|| .|||...:..|    |.|......:|
Zfish  1052 IQQRLQDTQTLLRQAKENKERGMLLIKDVERKS-KGTH-YPETDAFRCYT----TGFKTRMTGFL 1110

  Fly   210 FK-NSRIGDV----------------------------SNSSKLSACNSELPPEEYKGRTLYHDT 245
            .| ..|..|:                            |::|.:|.|.|.|...|.:   ..|
Zfish  1111 LKAEERKSDLQTSVDLYRFCEEASSLVKECMEYLDHMKSSNSPMSVCWSSLHAFEQR---FQH-- 1170

  Fly   246 KFDCAYIKNRRPLITTESKMSITEAEHPQTKYTDIKYDYKTCSISQGLH-----QNKAFLNKVPP 305
             |...:.::|...:.......|......||:..||:  .:...|.|..|     |::|.||.|..
Zfish  1171 -FSPQHFQDRSAALLERLPDGIWMWNAVQTQCRDIR--QRLSEILQAAHTHKDSQDEAQLNPVSG 1232

  Fly   306 SKQSKP-----------FHSVDYDYYENIQKLHLSKESERQIRDNGDPNDLQ----NFLKKNLIK 355
            ..|::.           ..|.:...:|.:....:.::|..:|:.:.:..:.:    :..|..|..
Zfish  1233 QTQNRAAEQGDNETLTYLQSAEGSKFEQVMTSSVHEQSASRIQQSVECTEQETRHLHETKDKLHN 1297

  Fly   356 ATT--NELLKAAAQSTKKCNIDLERKLNDLN------IKEEDHTSN--------DSGNSYKNDPY 404
            |::  ||....|.||. :|.:.....|.:.|      ...:|..|:        |...|:.::|.
Zfish  1298 ASSMHNESTSHAQQSV-QCTVQKASMLQETNNTSRNPSMHKDSASHIQESVQCTDQNTSHLHEPQ 1361

  Fly   405 LVSMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKD 469
            .:|...  |.:.::.::.       ...||| ::.|||.........:...|.:.|
Zfish  1362 AISHHP--SDRKLKEHHH-------KHSHSD-DDLRKSGRIHKFGQTAHYKVFIRS--------- 1407

  Fly   470 SICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDG 534
               .|.|.|.....|. |.....:.:..|:.|..||:  ::|.:. |::..||.......|..|
Zfish  1408 ---QSAESCLRGYRYN-IPLCKTDAAASCVGASLEGL--SSELNQ-HDSFCSSASGFSQKCSSD- 1464

  Fly   535 CSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHL 599
            |...|.|..|.. |.|..:..|    |.:.:...:|..|.                      |.|
Zfish  1465 CGSEDHGSGVRC-SDNAFTKQE----ESVCKPECILENTS----------------------TAL 1502

  Fly   600 PKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANV 664
                         ::||     |::||.:||:.||..:|.:::.|...|:..: .|..|:|:..:
Zfish  1503 -------------KLQR-----IMQELLQTEQEYVRALAYVVENYMPELERPD-VPQDLRGQRGL 1548

  Fly   665 LFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDT 729
            :||||.::..||...|:::||.|:.....|..||:|.::.| .||:.|.:|..|||.|  .:...
Zfish  1549 IFGNLEKLRDFHQHHFIQELELCLEKPFSVGRCFLKHKESF-GLYALYSKNKPRSENL--LIQHG 1610

  Fly   730 HMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLL----LFTDNDSCRNELKNALDCMLIV 790
            ..|||:.|..|...|.|.:|||||||||:||.|||:|||    ..|:.:..|.|:..||:.:...
Zfish  1611 KDFFKQKQQLLKDALDLSSYLLKPVQRISKYSLLLQDLLRECECVTNAELQRTEIHTALNIIQFQ 1675

  Fly   791 LKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQ 855
            |:..|:.:....|.|...:|.:||:|:.||.|.:....||..        |||||:| .|:|..:
Zfish  1676 LRHGNNLLAMDDIYGCDVNLKEQGQLIRQDEFLLTFRKKKCY--------RHIFLFQ-DLILFSK 1731

  Fly   856 TSKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKR-FEVWLKGR--QEVYTLQASTIGVKEMWVAE 917
            |.|:.....:|.:|...|.|.||:|.: |||:.. ||:|.:.|  |:.|.|||::..|||.|..:
Zfish  1732 TRKTDVGNDTYIYKQSFKTSDIGMTHN-SGDSGLCFEIWFRRRKTQDTYVLQAASREVKESWTRD 1795

  Fly   918 IKRVLFNQ 925
            ::|:|:.|
Zfish  1796 LERILWEQ 1803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	66/177 (37%)
		PH-like	802..925	CDD:302622	46/125 (37%)
		PH	829..922	CDD:278594	36/95 (38%)
quo	NP_001004109.2	SMC_N	<894..>1314	CDD:330553	78/406 (19%)
		RhoGEF	1507..1680	CDD:306973	66/176 (38%)
		PH_puratrophin-1	1673..1808	CDD:270062	49/141 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910