DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and Mcf2

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_008771798.1	Gene:	Mcf2 / 317598	RGDID:	1566098	Length:	1110	Species:	Rattus norvegicus

Alignment Length:	1001	Identity:	254/1001 - (25%)
Similarity:	419/1001 - (41%)	Gaps:	248/1001 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 CNSELPPEEYKGRTLYH----------DTKFDCAYIKNRRPLITTESKMSITE--AEHP------ 273
            ||....|||...:.|.:          |::|  ..|.:||....:..|:|:.:  |..|
  Rat   139 CNFRCIPEEVIAKVLNYLTSIARQSGSDSRF--TIILDRRMDTWSSLKISLQKISASFPGNLHLV 201

  Fly   274 ---------QTKYTDIKYDYKTCSISQGLHQNKAFLNKVP--------------PSKQSKP---- 311
                     |..:|||.:.:          ..:.|:.|:|              ..||..|
  Rat   202 LVLRPTSFLQRTFTDIGFRF----------SQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGG 256

  Fly   312 ----FHSVDYDYYENIQKLHLS-KESERQIRDNGD-------PNDL-------------QNFLKK 351
                .||....:...|:|..:: ||..:.::..|.       |:|:             .:.||.
  Rat   257 TLQYCHSEWIIFRNAIEKFAVTVKEMAQMLQSFGTELAETELPDDIPSIEEILAGRAERYHLLKN 321

  Fly   352 NLIKAT--------------TNELLKAAAQSTKKCNID---LERKLNDLNIKEEDHTSNDSGNSY 399
            :|...|              |.|.|.::.:..:..|.|   :::.|..::..|.........:..
  Rat   322 DLTTVTKEGKVLLMNLQVPDTEENLSSSHECPQHINGDWQTIKKLLAQVHDMETAFDGFWEKHQL 386

  Fly   400 KNDPYL-------VSMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFM---PQSVDLLSSA 454
            |.:.||       .....:...:|:.|..|:...:  ||:.:.:.:..|...   .:|.:||:..
  Rat   387 KMEQYLQLWKFEQEFQEVVTQVEFLLSQQRELGDV--TGNLAQVKQRLKKIEILDDKSQELLAKG 449

  Fly   455 SVSLSSCDGSCLNKDSICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENL 519
            .:.:  ..|..|..:.....:..|..|||.:       .||...:|.:.......:.....|..|
  Rat   450 RIVI--LHGHKLASNHHYALDLICQRCNELR-------YLSDILVNEIRSKRIQLSRTFKMHRLL 505

  Fly   520 TSSCCCSGSFCDDDGCSYLDEG------------------------------------------L 542
            ..:..|    ||...|...:.|                                          |
  Rat   506 QQARQC----CDQGECLLANRGMDKFQTKEDAQKALQDVDNFLQMAMPFINYDIENLQFEFDVLL 566

  Fly   543 SVDIKS---------KNVQSLHESGTDE-KLSR--------------KTILLARTEDTNDVTQGI 583
            |.::|:         :|::|:.|:..:. |:|:              ::::.|||...:....||
  Rat   567 SPELKAQMKNIQRKLENIRSVFENQQNAYKISKDRPEGAVQRMIPAPESVMRARTIFFSPKHVGI 631

  Fly   584 SDGTTYFTGSLNITHLPK--------SNEIFKKPQDPEMQRH------------RRGHILKELFE 628
              |.::|......:.:.|        ||...:..||.:.:..            .:.|:|.||.:
  Rat   632 --GYSFFQACKIFSKVKKSWRQIQAQSNVKVQATQDSQEKNFDQPPKLDSSLDILKNHVLNELIQ 694

  Fly   629 TEKIYVNEIASILKGYYDRLKSDES---APASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISV 690
            ||:.||.|:.::|.||...:.:.:.   .|..|:.|.:|||||:.|||.|||::|:..||:|...
  Rat   695 TERAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDA 759

  Fly   691 TERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQ 755
            .|||..||::|::.| |:|:.||||..|||.:.....:. .||:|||..|.|:|.|.:|||||||
  Rat   760 PERVGPCFLERKEDF-QMYAKYCQNKPRSELIWRKYSEC-AFFQECQRKLKHRLGLDSYLLKPVQ 822

  Fly   756 RITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQD 820
            ||||||||||:||.::.......:||.|||.||.:||.|||||||.:|.|:.|::...|::::|.
  Rat   823 RITKYQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNMNDLGKMILQG 887

  Fly   821 SFQVWIESKKDIR-----LRMKPKRRHIFLYQKSLLLCKQTSKSGYNKS---SYQFKSDVKMSQI 877
            :|.||:..:|...     .|.||.:||:|||:|:::.||:..:||....   ||.||..:||.:.
  Rat   888 AFSVWVGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEEA 952

  Fly   878 GLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLE----KLKGDQIA--- 935
            |:||.|.||.::||:|...::|:|.:||..|.||.:|:.||:.:|..|.|    |.:.||::
  Rat   953 GITEHVKGDNRKFEIWYGEKEEIYIVQAPNIDVKMLWLKEIRNILLKQQELLTAKTQQDQLSDQD 1017

  Fly   936 -----RYNIRHQSLWQKSSCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEKTCLSDQNIV--- 992
                 :.|...|.....::.||......:....|..|..|       .:::|..|.:...::
  Rat  1018 QLPPQQQNAEKQEETLLNAVEAGAEVEQASAMMEVREAAL-------LVQAEANCTTWNGMLPCT 1075

  Fly   993 NGPSVQDQHEKNSWSSDCSDIDEDET 1018
            .|.:...:|..||.|.: ||..||.:
  Rat  1076 EGTAATAEHPCNSLSPN-SDNGEDRS 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	83/176 (47%)
		PH-like	802..925	CDD:302622	48/130 (37%)
		PH	829..922	CDD:278594	39/100 (39%)
Mcf2	XP_008771798.1	SEC14	119..259	CDD:214706	25/131 (19%)
		SPEC	399..590	CDD:295325	30/205 (15%)
		RhoGEF	685..862	CDD:238091	83/178 (47%)
		PH-like	869..1000	CDD:302622	48/130 (37%)
		PH	884..997	CDD:278594	43/112 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm44888
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	LDO	PTHR22826
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.960