DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and Arhgef25

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_006241516.1	Gene:	Arhgef25 / 314904	RGDID:	735210	Length:	613	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	149/542 - (27%)
Similarity:	237/542 - (43%)	Gaps:	113/542 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PQSVDLLSSASVSLSSCDGSCLNKD-------------------SICGSEEDCCE---------- 480
            ||..|.|...|....|   .|..:|                   ||.|||.....
  Rat    34 PQERDPLGPGSTKTES---ECTEEDQTGEREREVLAWAPQPESYSIAGSEGSMSASAVSGLAALS 95

  Fly   481 -----CNEYQCIATPPNEL---------SKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCD 531
                 .:.:.|...||..:         ||.||:.       .||.|   ...|..|
  Rat    96 GPSSGLSSHPCSPVPPGPVTGLRRWLDHSKHCLSV-------ETEAD---SGQTRQC-------- 142

  Fly   532 DDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNI 596
                             :|........|.::|...|:|....|......|...:.|        :
  Rat   143 -----------------ENWMLEPTLTTGQELPELTLLTTLLEGPGVKAQPAEEET--------L 182

  Fly   597 THLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGK 661
            :..||:.|..||     ....|...:|.||.|||::||:::..|::||...: :.:..|.||:|:
  Rat   183 SQAPKNEEEQKK-----TALERSMFVLSELVETERMYVDDLGQIVEGYMATM-ATQGVPESLRGR 241

  Fly   662 ANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETL 726
            ..::|||:.:||.:|.|.||::|:.|:...:.:|..|:|...:.: :|..||||..:||.:....
  Rat   242 DRIVFGNIQQIYEWHRDYFLQELQQCLKDPDWLAQLFIKHERRLH-MYVVYCQNKPKSEHVLSEF 305

  Fly   727 VDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLF-----TDNDSCRNELKNALDC 786
            .|:  :|:|.:..|||:|.|...|:||||||.||||||||.|.:     .|.:    ||:.|::.
  Rat   306 GDS--YFEELRQQLGHRLQLSDLLIKPVQRIMKYQLLLKDFLKYYRRAGMDTE----ELEQAVEV 364

  Fly   787 MLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLL 851
            |..|.|..||.|....:.||.|.|..||:||.||:|.| .|.:....|..:.:.|.:||:::.::
  Rat   365 MCFVPKRCNDMMSLGRLRGFEGKLTAQGKLLGQDTFLV-TEPEAGGLLSSRGRERRVFLFEQIVI 428

  Fly   852 LCKQTSKSGY--NKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQ---EVYTLQASTIGVK 911
            ..:.....|.  .:..|.:|:.:|:|.:||..::.|:|.||.:..:|.:   :.|.||||...|.
  Rat   429 FSEALGGGGRGGTQPGYVYKNSIKVSCLGLEGNLQGNACRFALTSRGPEGGIQRYVLQASDPAVS 493

  Fly   912 EMWVAEIKRVLFNQLEKLKGDQ 933
            :.|:.::.::|.:|.:.|...|
  Rat   494 QAWIKQVAQILESQRDFLNALQ 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	67/178 (38%)
		PH-like	802..925	CDD:302622	37/127 (29%)
		PH	829..922	CDD:278594	23/97 (24%)
Arhgef25	XP_006241516.1	RhoGEF	203..374	CDD:279015	67/178 (38%)
Arhgef25	XP_006241516.1	PH2_Kalirin_Trio_p63RhoGEF	378..520	CDD:270061	40/139 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810