Protein Alignment CG30440 and Plekhg4

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_038954139.1
• Gene: Plekhg4 / 307796
• RGDID: 1310790
• Length: 1231
• Species: Rattus norvegicus
• Alignment Length: 1120
• Identity: 249/1120 - (22%)
• Similarity: 427/1120 - (38%)
• Gaps: 290/1120 - (25%)

  Fly    45 YRSSEPQIAARRNKKTRFVGNRRQL--------------------------RNLSQPENSHKTSR 83
            :.|.:||....::...|..||:|.:                          .||:|.||.|:...
  Rat    66 FLSKKPQSLPDQSAADRSGGNQRSILGAPQAQSEEPAFSEMENCLCPGSSHLNLTQGENDHRGGG 130

  Fly    84 SL-CPDTAKTEPKVYS-LRFVLNKSEDKDYMSRLKAQNDFSQ-SSC-LCNNLSHANTEAGAYQND 144
            .: .|:..:..|..:| |..:.:|..:.|     .:.:.|.: :.| |..:|:.....:|.....
  Rat   131 LIGDPEPGRALPAGFSPLLEMSSKLPEAD-----PSGSSFPRPADCLLARDLTWELLASGMAALP 190

  Fly   145 GILKG----------QRDHSDFLTAAGGIQSRADRIARIETCGIRTTHL---------------- 183
            |.|.|          .|.||...|....|:.||..:    .|......|
  Rat   191 GSLGGLMRWRKWPGKARIHSLLSTGTRDIEGRAVLL----LCAHSPAWLHPKCNSHELLSLLFYL 251

  Fly   184 ----QPETQIL-------KPVTEPNE------TRFDQHSPDWLFKNSRIGDV------------- 218
                :||.|.|       ..:..|:.      ::..:.||..:.:...:|.:
  Rat   252 RGIPRPEVQALGLTVLVDARICPPSSALTWGLSQLQEASPGSVQQLLLVGKMPEDMPVGLQAKQL 316

  Fly   219 -SNSSKLSAC-NSELPPE-------------EYKGR--TLYHDTKFDCAYIKN--------RRPL 258
             |:.|.|:.. |.|||..             :::.|  ||....:..||.::.        |:||
  Rat   317 ASHQSLLTHIPNMELPTSLGGCLSYCHQAWLDFRMRLETLQQSCQVACALLQGVIDSMKAMRQPL 381

  Fly   259 ITTESKMSITEA--------EHPQTKYTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSV 315
            .:.|....:.:|        |.||..:..          ||| ....|:|      ||..|..::
  Rat   382 ESGEVGELLQQAQSLMQQVLESPQLSWLQ----------SQG-SLELAWL------KQGMPQVAL 429

  Fly   316 DYDYYENIQK-----------LH-LSKESERQIRDNGDPNDLQNFLKKNLIKATTNELLKA-AAQ 367
            ..||...:.|           || |:.:|.::||                    ..|||:| .||
  Rat   430 SPDYRSAVDKADELYGQVDELLHRLTLKSNQRIR--------------------ALELLQALEAQ 474

  Fly   368 STKKCNIDL-ERKLNDLNIKEEDHTSND-----SGNSYKNDPYLVSMSKINSCKFIRS--YNRDC 424
            ....|.|:: .:::....::|....|.|     .|...:.|  ||:..::...:.:..  ...:.
  Rat   475 EGVLCQIEVWLQEVGWPGLEEPGEPSLDMLLQAQGPFQELD--LVAQEQVKQGEKLLQPLVGWEA 537

  Fly   425 ETIFPTGD-----HSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCECNEY 484
            ..:.|||.     .|.|.||.:: :.|....|:.|.....      ..|.:...:||.
  Rat   538 AELGPTGKRFLALRSQLMEFSRA-LAQRRQRLADAEKLFQ------FFKQASTWTEEG------- 588

  Fly   485 QCIATPPNELSKDCLNAVEEGVFCN-TEYDDF----------------HENLTSSCCCSGSFCDD 532
            |.:.|   ||.::....|.:.:..: :::.|.                .|.:...|..:.:.|.|
  Rat   589 QRVLT---ELEQETPEVVLQRLQLHWSKHPDLPPAHFRKMWALATGLGSEGIRQECRWAWAQCQD 650

  Fly   533 DGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLARTEDTNDVTQG--ISDGTT--YFTGS 593
            ...: ||:.....:|.:::.|..........:..||...|...:.|...|  :.|.:.  :...:
  Rat   651 TWLA-LDQKREAALKPQSMNSTATLYVRRAPAIPTIPPLRKSYSFDQNLGKHLGDASNRGHCAAT 714

  Fly   594 LNITHLPKSNEIFKKPQDPEM---------QRHRRGHILKELFETEKIYVNEIASILKGYYDRL- 648
            :...|.|::....:....|.:         ..:|...:|.|:..||:.||..:...::.|:..|
  Rat   715 VTDCHRPEARGGIRPRSSPSVPLSGSSDFRSPNRLQLVLAEMVATEREYVRALDYTIQNYFPELD 779

  Fly   649 KSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYC 713
            :||  .|..|:|:...|||||.::..||...||::||.|.....|||..|::.|.:| .:|:.|.
  Rat   780 RSD--VPQGLRGQRAHLFGNLEKLRDFHFHFFLRELEACTRHPPRVAHAFLRHRVQF-GMYALYS 841

  Fly   714 QNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSC-- 776
            :|..||:.|....  .|.||||.|..||..|.|.:|||||:||::||.|||::|.     .:|
  Rat   842 KNKPRSDALMSNY--GHTFFKEKQQALGDHLDLASYLLKPIQRMSKYALLLQELA-----RACGG 899

  Fly   777 ----RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESKKDIRLRMK 837
                ...|:.|...:...|:..||.:...:|.|...:|.:||:|:.||.|.|.....|..
  Rat   900 PAQELGALQAAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFTVRAGHHKSC----- 959

  Fly   838 PKRRHIFLYQKSLLLCK-QTSKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGR--QE 899
               |.:||:::.||..| :...:|.:  .:.:|...||:.:||||.......|||:|.:.|  ::
  Rat   960 ---RRVFLFEELLLFSKPRRGPAGVD--IFTYKRSFKMADLGLTECCGESKLRFEIWFRRRKARD 1019

  Fly   900 VYTLQASTIGVKEMWVAEIKRVLFNQL---EKLKGDQIARYNIRHQSLWQKSSCEAPNITHCSLR 961
            ::.||||.:..|:.|.|:|.|:|:.|.   ::::..::|...:.:::.|.    .||:
  Rat  1020 LFVLQASDVATKQAWTADISRLLWRQAVHNKEVRMAEMASMGVGNKAFWD----IAPS------- 1073

  Fly   962 RTECFELPLNDSNRN 976
                 |..:||.|.|
  Rat  1074 -----EEAINDRNIN 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	64/180 (36%)
		PH-like	802..925	CDD:302622	40/125 (32%)
		PH	829..922	CDD:278594	29/95 (31%)
Plekhg4	XP_038954139.1	SPEC	463..>614	CDD:413338	34/189 (18%)
		RhoGEF	749..915	CDD:238091	63/175 (36%)
		PH_puratrophin-1	915..1050	CDD:270062	44/144 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910