Protein Alignment CG30440 and Vav2

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_038960659.1
• Gene: Vav2 / 296603
• RGDID: 1306285
• Length: 873
• Species: Rattus norvegicus
• Alignment Length: 662
• Identity: 131/662 - (19%)
• Similarity: 250/662 - (37%)
• Gaps: 198/662 - (29%)

  Fly   375 DLERKLND-LNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCKFIRSYNRDC--------ETIFPT 430
            ||.:.|.| :.:.:..|..:......|:..:...||:....|.||::.:.|        ..:|..
  Rat    32 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDP 96

  Fly   431 GDHSDLNEFRKSFMPQSVDLLSSASVSLSS------CDGSCLNKDSICGSEEDCCECNEYQCIAT 489
            .|..|:.:|.|  :..:|..||..|::.|.      .:.:..|.|.:..|.|:..:
  Rat    97 FDLFDVRDFGK--VISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSLEELAD--------- 150

  Fly   490 PPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSL 554
             .::|.:|..:.|.    |..|.||.:|::                      :.|::
  Rat   151 -EHDLGEDIYDCVP----CEDEGDDIYEDI----------------------IKVEV-------- 180

  Fly   555 HESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRR 619
                      ::.:.:..|||                                         .:|
  Rat   181 ----------QQPMKMGLTED-----------------------------------------DKR 194

  Fly   620 GHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDL 684
            ...|.|:.|||..|...:..|.|.|...|:...| |..:.    .:|.||.::...|:. ||:.:
  Rat   195 SCCLLEIQETEAKYYRTLEDIEKNYMGPLRQVLS-PVDMA----TIFINLEDLIKVHHS-FLRAI 253

  Fly   685 E-NCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLV----DTHMFFKECQIGLGH-K 743
            : :.::....:|..|::.:::.. :|..||.:::.::.....|:    |.....:||.:.:.. |
  Rat   254 DVSMMAGGSTLAKVFLEFKERLL-IYGEYCSHMEHAQSALNQLLASRDDFRQKVEECTLKVQEGK 317

  Fly   744 LPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVND-----------S 797
            ..|...|:.|:||:.||.||||:||..:.:...|.:||.||:.|..:...:|:           |
  Rat   318 FKLQDLLVVPMQRVLKYHLLLKELLSHSADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKIS 382

  Fly   798 MHQISITGFSGDLAK------QGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQT 856
            ..|.||......|.:      .|||.::   .:...:|:|         |::||:.|.:::||
  Rat   383 EFQCSIENLQVKLEEFGRPKIDGELKVR---SIVNHTKQD---------RYLFLFDKVVIVCK-- 433

  Fly   857 SKSGYNKSSYQFKSDVKMSQIGLTESV--SGDAKRF--EVW--------LKGRQEVYTLQASTIG 909
             :.||   ||:.|..:::....:|:..  :.|.|:.  ::|        |:|:|. :.....|..
  Rat   434 -RKGY---SYELKEVIELLFHKMTDDPMHNKDIKKSHGKMWSYGFYLIHLQGKQG-FQFFCKTED 493

  Fly   910 VKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLW-----QKSSCEAPNI------------TH 957
            :|..|:.:.:..:.|    :|.|   :.|..|.|..     :.::|:|..:            |.
  Rat   494 MKRKWMEQFEMAMSN----IKPD---KANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTR 551

  Fly   958 CSL-RRTECFEL 968
            |.: ...||.|:
  Rat   552 CGVGAHKECLEV 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	47/179 (26%)
		PH-like	802..925	CDD:473070	29/140 (21%)
Vav2	XP_038960659.1	CH_VAV2	2..120	CDD:409112	20/89 (22%)
		RhoGEF	197..369	CDD:459876	47/178 (26%)
		PH_Vav	384..511	CDD:269930	31/149 (21%)
		C1_VAV2	514..571	CDD:410418	10/50 (20%)
		SH3_VAV2_1	585..644	CDD:212913
		SH2_Vav2	662..764	CDD:198269
		SH3_VAV2_2	814..871	CDD:212910