DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30440 and Arhgef40

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	XP_006519104.1	Gene:	Arhgef40 / 268739	MGIID:	2685515	Length:	1524	Species:	Mus musculus

Alignment Length:	450	Identity:	112/450 - (24%)
Similarity:	188/450 - (41%)	Gaps:	100/450 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 CSGSFCDDDGCSYLDEGLSVDIKSKN-------VQSLHESGT---DEKLS-RKTILLARTEDTND 578
            ||.:.|.:|   |.:|||.:..::..       ::.|..:.|   |...| |:.:||.|.
Mouse  1005 CSLTPCGED---YEEEGLELAPETDGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRA----- 1061

  Fly   579 VTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHR----RGHILKELFETEKIYVNEIAS 639
               |..|| .:..|:                  |.|:|.|    :..::.||...|:.||..:..
Mouse  1062 ---GGPDG-PWGIGT------------------PRMERKRSISAQQRLVSELIACEQEYVTTLNE 1104

  Fly   640 ILKGYYDRLKSDESAP-------ASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALC 697
            .:.     |...|..|       |:|..:        ..:.|||...||::|:.|.:...|:..|
Mouse  1105 PVP-----LPGPELTPELRCTWAAALSVR--------ERLRSFHGTHFLQELQGCAAHPLRIGAC 1156

  Fly   698 FVKRRDKFYQLYSFYCQNIQRSEKLRETL------VDTHMFFKECQIGLGHKLPLGAYLLKPVQR 756
            |::..|:|    :.|.|.::...||...|      |...|....|       ||..  |.:|:::
Mouse  1157 FLRHGDQF----NLYAQFVKHRHKLESGLAALTPSVKGSMESSPC-------LPRA--LQQPLEQ 1208

  Fly   757 ITKYQLLLKDLL--LFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQ 819
            :.:|..||::||  ...:..|.|..|:.|:..:........|.:...::.|...||.:||:||.:
Mouse  1209 LARYGQLLEELLREAGPELSSERQALRAAVQLLQEQEARGRDLLAVEAVRGCEIDLKEQGQLLHR 1273

  Fly   820 DSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSSYQFKSDVKMSQIGLTESVS 884
            |.|.|....||.:        ||:||::..||..|.....| ...::.:|...|.:.:||||::.
Mouse  1274 DPFTVICGRKKCL--------RHVFLFEDLLLFSKLKGSEG-GSETFVYKQAFKTADMGLTENIG 1329

  Fly   885 GDAKRFEVWLKGR--QEVYTLQASTIGVKEMWVAEIKRVLFNQL---EKLKGDQIARYNI 939
            .....||:|.:.|  :|.|||||::...|..|.:.|.::|:.|.   ::|:..|:....|
Mouse  1330 DSGLCFELWFRRRRAREAYTLQATSPETKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGI 1389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	43/188 (23%)
		PH-like	802..925	CDD:302622	40/124 (32%)
		PH	829..922	CDD:278594	29/94 (31%)
Arhgef40	XP_006519104.1	RecN	<755..>874	CDD:223571
		RhoGEF	1084..1243	CDD:383033	43/184 (23%)
		PH_puratrophin-1	1242..1377	CDD:270062	42/143 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810