DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30440 and TIAM2

DIOPT Version :10

Sequence 1:NP_610172.1 Gene:CG30440 / 35496 FlyBaseID:FBgn0050440 Length:1057 Species:Drosophila melanogaster
Sequence 2:NP_036586.3 Gene:TIAM2 / 26230 HGNCID:11806 Length:1701 Species:Homo sapiens


Alignment Length:1321 Identity:265/1321 - (20%)
Similarity:455/1321 - (34%) Gaps:468/1321 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAPKMQIHPTKMEEDSDTRNSTYVPKMELLMTHYIHEGK---KAIMYRSSEPQIAARRNKKTRF 62
            :|..|.::...:.:|.||..:|    :.:.|.|..  :|.   .|.::.....||.::|::.|..
Human   390 LSRKKRKLQEPRSKEGSDYFDS----RSDGLNTDV--QGSSQASAFLWSGGSTQILSQRSESTHA 448

  Fly    63 VGN-----------RRQLR----NLSQPENSHKTSRSLCPDTAKTEPKVYSLRFVLNKSE----- 107
            :|:           .|:|.    |....|.|.:|:.|.....:..|    .|..:..|.:     
Human   449 IGSDPLRQNIYENFMRELEMSRTNTENIETSTETAESSSESLSSLE----QLDLLFEKEQGVVRK 509

  Fly   108 ------------DKDYMSRLKAQNDFSQSSCLCNNLSHANTEAGA----YQNDGILKGQRDHSDF 156
                        .|:....|.|:..:.|         :..|..|.    |:..|  |...|    
Human   510 AGWLFFKPLVTVQKERKLELVARRKWKQ---------YWVTLKGCTLLFYETYG--KNSMD---- 559

  Fly   157 LTAAGGIQSRADRIARIETCGIRTTHLQPETQILKPVTE--PNETRF---DQHSPDWLFKNSRIG 216
                   ||.|.|.|           |..|..|::.|.|  ..|..|   :.....:||:.:...
Human   560 -------QSSAPRCA-----------LFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQT 606

  Fly   217 DVSN--SSKLSACNSELPPEEYKGRTLYHDTKFDCAYIKNRRPLITTESKMSITEAEHPQTKYTD 279
            |:.|  ::..|||.|....:..|..||        ..:||:     |::.:...:.:....|..:
Human   607 DLENWVTAVHSACASLFAKKHGKEDTL--------RLLKNQ-----TKNLLQKIDMDSKMKKMAE 658

  Fly   280 IKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENIQKLHLSKESERQIRDNGDPND 344
            ::                  |:.|...|..|...:....:.:|::|.|:.....|....:....:
Human   659 LQ------------------LSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGE 705

  Fly   345 LQNFLKKNLIKATTNE---------LLKAAAQSTKKCNID---LERKLNDLNIKEEDHTSNDSGN 397
            |.|  .|:|:.|.:..         :|..::.....|:.|   |.::  .|::.:.........:
Human   706 LPN--PKSLLAAASRPSKLALGRLGILSVSSFHALVCSRDDSALRKR--TLSLTQRGRNKKGIFS 766

  Fly   398 SYKNDPYLV--------SMSKINSCKFIRSYN-------RDCETIFPTGDH-SDLNEFRKSFMPQ 446
            |.|....|.        |:::::  :.:..|.       ||......|..| .|.:.......|:
Human   767 SLKGLDTLARKGKEKRPSITQVD--ELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPE 829

  Fly   447 S--VDLLSSASVSLSSCD---------GSCLNK---DSICGSEEDCCECNEYQCIATPPNELSKD 497
            .  .|:|:.|      |.         |..|.|   |::           || ||..|...:.:.
Human   830 HRVEDILTLA------CKMRQLEPSHYGLQLRKLVDDNV-----------EY-CIPAPYEYMQQQ 876

  Fly   498 CLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCD------------------------DDGCSYL 538
            ..:.:|  ||....||   ..||.    :||.||                        .||.:| 
Human   877 VYDEIE--VFPLNVYD---VQLTK----TGSVCDFGFAVTAQVDERQHLSRIFISDVLPDGLAY- 931

  Fly   539 DEGLSVDIKSKNVQSLH-ESGTDEKL-------SRKTI---LLARTEDTN--------------- 577
            .|||.   |...:.:|: |:.:|..|       |.|::   |:||..||.               
Human   932 GEGLR---KGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSR 993

  Fly   578 ----------------------------------DVTQGISDGTTYFTGSLN-ITHLPKSNEIF- 606
                                              |:|.|:....|  .|:|: ::|..|..:.| 
Human   994 DQKSLLPPPNQSQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQT--DGTLDQVSHREKMEQTFR 1056

  Fly   607 -----------------------KKPQDP---EMQRH-----RRGHILKELFETEKIYVNEIASI 640
                                   ::.|||   .:.||     |...:::||.:|||.||.:::.:
Human  1057 SAEQITALCRSFNDSQANGMEGPRENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCL 1121

  Fly   641 LKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTE-----------RV 694
            .:.|.:.|:::...   .|.:...|||:|.|:..|.. |||:.||:.||.:.           |.
Human  1122 FELYLEPLQNETFL---TQDEMESLFGSLPEMLEFQK-VFLETLEDGISASSDFNTLETPSQFRK 1182

  Fly   695 AL-----CFVKRRDKFYQLYSFYCQN---IQ------RSEKLRETLVDTHMFFKECQIGLGHKLP 745
            .|     .|:...|.| :|||.:|.|   :|      :::|..:..:|.....|:      |...
Human  1183 LLFSLGGSFLYYADHF-KLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQ------HSST 1240

  Fly   746 LGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRN-ELKNALDCMLIVLKCVND--SMHQISITGFS 807
            |.:||:|||||:.||.||||:|:..||.:|..: .|..||..|..|...:|:  .:::...|.|.
Human  1241 LESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFD 1305

  Fly   808 GDLAKQ------------GELLMQDSFQVWI-------ESKKDIRLRMKPKRRHIFLYQKSLLL- 852
            ..:|:|            |||||..:.. |:       :::||:.|.       :|:::::::| 
Human  1306 QLVAEQSGTEKEVTELSMGELLMHSTVS-WLNPFLSLGKARKDLELT-------VFVFKRAVILV 1362

  Fly   853 ----CK------QTSKSGYNKSS---YQFKSDVKMSQIGLTESVSGDAKRFEVW--------LKG 896
                ||      ..|:..:|.:.   ::|:..:.:|.:.:........:...:|        ::|
Human  1363 YKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEG 1427

  Fly   897 RQE-VYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQKSSCEAPNITHCSL 960
            |.| ::.|..|....|...|..|:.:|             |.|.|                    
Human  1428 RPETIFQLCCSDSESKTNIVKVIRSIL-------------RENFR-------------------- 1459

  Fly   961 RRTECFELPLNDSNRNTNIRSEKTC------LSDQNIVNGP-------SVQDQHEKNSWSSDCSD 1012
            |..:| ||||           ||||      |.::..|:..       .|......|.|:.:...
Human  1460 RHIKC-ELPL-----------EKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGK 1512

  Fly  1013 ---IDEDETINPILMQKTGQP 1030
               :|.||.......|.:|.|
Human  1513 GTLLDSDEGSLSSGTQSSGCP 1533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30440NP_610172.1 RhoGEF 622..796 CDD:214619 61/199 (31%)
PH-like 802..925 CDD:473070 31/164 (19%)
TIAM2NP_036586.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..250
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..293
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..417 6/30 (20%)
PH1_Tiam1_2 505..631 CDD:269937 31/158 (20%)
Tiam_CC_Ex 645..742 CDD:408184 16/116 (14%)
Ubl1_cv_Nsp3_N-like 811..881 CDD:475130 17/87 (20%)
PDZ 887..976 CDD:214570 24/99 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1092 3/21 (14%)
RhoGEF 1103..1292 CDD:214619 61/199 (31%)
PH2_Tiam1_2 1294..1466 CDD:269957 36/213 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1500..1556 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1568..1628
Blue background indicates that the domain is not in the aligned region.

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