DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30440 and PLEKHG4

DIOPT Version :10

Sequence 1:NP_610172.1 Gene:CG30440 / 35496 FlyBaseID:FBgn0050440 Length:1057 Species:Drosophila melanogaster
Sequence 2:NP_001123199.1 Gene:PLEKHG4 / 25894 HGNCID:24501 Length:1191 Species:Homo sapiens


Alignment Length:495 Identity:135/495 - (27%)
Similarity:224/495 - (45%) Gaps:73/495 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   517 ENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNV---QSLHESGTDEKLSRKTILLARTEDTND 578
            |.:...|..:.:.|.|...: ||:.|...:|...|   .||..|......:...:..|.:.|.| 
Human   619 EAIRQECRWAWARCQDTWLA-LDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRN- 681

  Fly   579 VTQGISDGTTYFTGSLNIT----------HLPKSNEIFKKP--QDPEMQRHRRGHILKELFETEK 631
            :.|.:|:...:...:..|.          .||:::.....|  .||. ..:|...:|.|:..||:
Human   682 LGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPR-SLNRLQLVLAEMVATER 745

  Fly   632 IYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVAL 696
            .||..:...::.|:..|...: .|..|:|:...|||||.::..||...||::||.|.....|||.
Human   746 EYVRALEYTMENYFPELDRPD-VPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAY 809

  Fly   697 CFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQ 761
            .|::.|.:| .:|:.|.:|..||:.|..:.  .|.|||:.|..||..|.|.:|||||:||:.||.
Human   810 AFLRHRVQF-GMYALYSKNKPRSDALMSSY--GHTFFKDKQQALGDHLDLASYLLKPIQRMGKYA 871

  Fly   762 LLLKDLLLFTDNDSC------RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQD 820
            |||::|.     .:|      .:.|:.|...:...|:..||.:...:|.|...:|.:||:|:.||
Human   872 LLLQELA-----RACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931

  Fly   821 SFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCK-QTSKSGYNKSSYQFKSDVKMSQIGLTESVS 884
            .|.|.....|.:        |.|||:::.||..| :...:|.:  ::.:|...||:.:||||...
Human   932 EFVVRTGRHKSV--------RRIFLFEELLLFSKPRHGPTGVD--TFAYKRSFKMADLGLTECCG 986

  Fly   885 GDAKRFEVWLKGR--QEVYTLQASTIGVKEMWVAEIKRVLFNQL--------------------- 926
            ....|||:|.:.|  ::.:.||||::.:|:.|.|:|..:|:.|.                     
Human   987 NSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAF 1051

  Fly   927 ------EKLKGDQIARYNIRHQSLWQKSSCEAPNITHCSL 960
                  |:...|:...|.::.:.:..::|.......|.||
Human  1052 RDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSL 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30440NP_610172.1 RhoGEF 622..796 CDD:214619 61/179 (34%)
PH-like 802..925 CDD:473070 40/125 (32%)
PLEKHG4NP_001123199.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..152
SEC14 193..321 CDD:469559
SPEC 447..>598 CDD:413338
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..728 4/20 (20%)
RhoGEF 736..898 CDD:459876 60/170 (35%)
PH_puratrophin-1 899..1034 CDD:270062 44/144 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1176
Blue background indicates that the domain is not in the aligned region.

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