DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30440 and PLEKHG4

DIOPT Version :9

Sequence 1:NP_610172.1 Gene:CG30440 / 35496 FlyBaseID:FBgn0050440 Length:1057 Species:Drosophila melanogaster
Sequence 2:NP_001123199.1 Gene:PLEKHG4 / 25894 HGNCID:24501 Length:1191 Species:Homo sapiens


Alignment Length:495 Identity:135/495 - (27%)
Similarity:224/495 - (45%) Gaps:73/495 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   517 ENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNV---QSLHESGTDEKLSRKTILLARTEDTND 578
            |.:...|..:.:.|.|...: ||:.|...:|...|   .||..|......:...:..|.:.|.| 
Human   619 EAIRQECRWAWARCQDTWLA-LDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRN- 681

  Fly   579 VTQGISDGTTYFTGSLNIT----------HLPKSNEIFKKP--QDPEMQRHRRGHILKELFETEK 631
            :.|.:|:...:...:..|.          .||:::.....|  .||. ..:|...:|.|:..||:
Human   682 LGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPR-SLNRLQLVLAEMVATER 745

  Fly   632 IYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVAL 696
            .||..:...::.|:..|...: .|..|:|:...|||||.::..||...||::||.|.....|||.
Human   746 EYVRALEYTMENYFPELDRPD-VPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAY 809

  Fly   697 CFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQ 761
            .|::.|.:| .:|:.|.:|..||:.|..:.  .|.|||:.|..||..|.|.:|||||:||:.||.
Human   810 AFLRHRVQF-GMYALYSKNKPRSDALMSSY--GHTFFKDKQQALGDHLDLASYLLKPIQRMGKYA 871

  Fly   762 LLLKDLLLFTDNDSC------RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQD 820
            |||::|.     .:|      .:.|:.|...:...|:..||.:...:|.|...:|.:||:|:.||
Human   872 LLLQELA-----RACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931

  Fly   821 SFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCK-QTSKSGYNKSSYQFKSDVKMSQIGLTESVS 884
            .|.|.....|.:        |.|||:::.||..| :...:|.:  ::.:|...||:.:||||...
Human   932 EFVVRTGRHKSV--------RRIFLFEELLLFSKPRHGPTGVD--TFAYKRSFKMADLGLTECCG 986

  Fly   885 GDAKRFEVWLKGR--QEVYTLQASTIGVKEMWVAEIKRVLFNQL--------------------- 926
            ....|||:|.:.|  ::.:.||||::.:|:.|.|:|..:|:.|.                     
Human   987 NSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAF 1051

  Fly   927 ------EKLKGDQIARYNIRHQSLWQKSSCEAPNITHCSL 960
                  |:...|:...|.::.:.:..::|.......|.||
Human  1052 RDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSL 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30440NP_610172.1 RhoGEF 622..796 CDD:214619 61/179 (34%)
PH-like 802..925 CDD:302622 40/125 (32%)
PH 829..922 CDD:278594 29/95 (31%)
PLEKHG4NP_001123199.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..152
SPEC 447..>598 CDD:321951
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..728 4/20 (20%)
RhoGEF 736..906 CDD:306973 61/178 (34%)
PH_puratrophin-1 899..1034 CDD:270062 44/144 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1176
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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