Protein Alignment CG30440 and MCF2L

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_011535788.2
• Gene: MCF2L / 23263
• HGNCID: 14576
• Length: 1238
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 290/1087 - (26%)
• Similarity: 438/1087 - (40%)
• Gaps: 299/1087 - (27%)

  Fly   163 IQSRADRIARIETCGIRTTHLQPETQILKPVTEPNETRFDQHS-PDWLFKNSR------------ 214
            |..|.|:...::...:|.....|....|..|..|  |.|.|.: .|..||.:|
Human   162 IDRRRDKWTSVKASVLRIAASFPANLQLVLVLRP--TGFFQRTLSDIAFKFNRDDFKMKVPVIML 224

  Fly   215 --IGDVSNSSKLSACNSELPPEEYKGRTL-YHDTKFDCAYIKNRRPLITTESKMSITEAEHPQT- 275
              :.|:......|....:|      |.|| |..:::.|     :|..|.:.:.|....|:..|:
Human   225 SSVPDLHGYIDKSQLTEDL------GGTLDYCHSRWLC-----QRTAIESFALMVKQTAQMLQSF 278

  Fly   276 ----KYTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENIQKLHLSKESERQI 336
                ..|::..|.::.|.....|..|....|.......|..|||    .|::::|. ::.||..:
Human   279 GTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV----LESLRELQ-AEGSEPSV 338

  Fly   337 RDNGDPNDLQNFLKK-----NLIKATTNELLKAAAQSTKKCNIDLERKLNDLNIKE--------- 387
              |.|..|.|..:::     |..:|..:|......|..::|   |:.:..:...:|
Human   339 --NQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQC---LQLRHFEQGFREVKAILDAAS 398

  Fly   388 -EDHTSNDSGNSYKNDPYLVSMSKINSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLL 451
             :..|..|.|||..:..:|:                           .||..|.:.   ..|.:.
Human   399 QKIATFTDIGNSLAHVEHLL---------------------------RDLASFEEK---SGVAVE 433

  Fly   452 SSASVSLSSCDGSCL--NKDSICGSEEDCCE-----CNEYQC-IATPPNELSKDCLNAVEEGVFC 508
            .:.::||   ||..|  ||.....|....|:     |:::.. ||.....|||..
Human   434 RARALSL---DGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSL---------- 485

  Fly   509 NTEYDDFHENLTSSCCCSGSFCDD----------DGCSYLDEGLSVDIKSKNVQSLHESGTDEKL 563
                 :.|..|.:|.    .:||:          |.|...|   ..:...:.::...|:|.:.|:
Human   486 -----ELHRRLETSM----KWCDEGIYLLASQPVDKCQSQD---GAEAALQEIEKFLETGAENKI 538

  Fly   564 SRKTILLARTED--TNDVTQGI--------SDGTTYFTGSLNITHL------------PKSNEIF 606
            .....:....|.  ..|:.:.:        |....:.....::..|            |:...:.
Human   539 QELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALA 603

  Fly   607 KKP---------------------QDP------EMQRHRRG----------------HILKELFE 628
            |.|                     :.|      ||...|:|                |::.||.:
Human   604 KSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLD 668

  Fly   629 TEKIYVNEIASILKGYYDRLKSDESA---PASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISV 690
            ||:.||.|:..:|:||...:.:...|   ...|..|.:|||||:.|||.|||.:||::|||....
Human   669 TERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDC 733

  Fly   691 TERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQ 755
            .|.|..||::|.:.| |:|..||||..|||.|.....|. .||:|||..|.|||.|.:|||||||
Human   734 PELVGRCFLERMEDF-QIYEKYCQNKPRSESLWRQCSDC-PFFQECQRKLDHKLSLDSYLLKPVQ 796

  Fly   756 RITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQD 820
            ||||||||||::|.::.|.....:|:.||..:|.:||.||||||.|:|||:.|:|...|:||||.
Human   797 RITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 861

  Fly   821 SFQVWIESK------KDIRLRMKPKRRHIFLYQKSLLLCKQTSKS--GYNKS-SYQFKSDVKMSQ 876
            ||.||.:.|      |:: .|.||.:||:||::|::|.||:..::  ||.|: ||.:|..:.|:.
Human   862 SFSVWTDHKRGHTKVKEL-ARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAA 925

  Fly   877 IGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRH 941
            :|:||:|.||||:||:|...|:|||.:||.|..:|..||.||::||.:||      |..|...:|
Human   926 VGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQL------QACREASQH 984

  Fly   942 QSLWQKSSCEAP-------------NITHCSLRRTECFEL-------PL------NDSNRNTNIR 980
            ::|.|..|...|             ||.....|:|:...|       ||      ...:..|:..
Human   985 RALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKDDTVTSSA 1049

  Fly   981 SEKTCLSD-----QNIVN------GPSVQD----QHEKNS------------------------- 1005
            ||.:.||.     |...|      .|:..|    :||..|
Human  1050 SESSALSRKRFTLQGFANLKGQKASPTSPDKKAKRHEVKSDPTPFGVRGWSKTSHSLEAPEDDGG 1114

  Fly  1006 WSS-----DCSDIDEDETINP----------ILMQKTGQPKLLWNRS 1037
            |||     :.||.:||..:.|          :...:.|.|..|..||
Human  1115 WSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRS 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	82/176 (47%)
		PH-like	802..925	CDD:302622	59/131 (45%)
		PH	829..922	CDD:278594	43/101 (43%)
MCF2L	XP_011535788.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3967
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm40749
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	O	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.870