DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30440 and MCF2L2

DIOPT Version :9

Sequence 1:NP_610172.1 Gene:CG30440 / 35496 FlyBaseID:FBgn0050440 Length:1057 Species:Drosophila melanogaster
Sequence 2:NP_055893.4 Gene:MCF2L2 / 23101 HGNCID:30319 Length:1114 Species:Homo sapiens


Alignment Length:899 Identity:216/899 - (24%)
Similarity:350/899 - (38%) Gaps:266/899 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 LSKE----SERQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKC-----NID-------L 376
            ||.|    |..:.||.     ||:.||  |:......||....:...||     |::       :
Human   234 LSTEDLLMSHTRQRDK-----LQDELK--LLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTM 291

  Fly   377 ERKLNDLNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCKFIRSYNRD-CETIFP----------- 429
            ||.|..|:..|:      :.:.:.::.:|    |:|.|..::.:..| |:....           
Human   292 ERLLVQLDETEK------AFSHFWSEHHL----KLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF 346

  Fly   430 TG-------------DHSDLNEFRKSFMP-QSVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCE 480
            ||             :|..|.|  ||..| :...||:             |..|.:..|.....:
Human   347 TGIGDSVMHVEQILKEHKKLEE--KSQEPLEKAQLLA-------------LVGDQLIQSHHYAAD 396

  Fly   481 CNEYQCIATPPNELSKDCLNAVEEGVFCNTEYD------DFHENL--TSSCCCSGSF-------- 529
            ....:|:..  ..|..|.:|..::      ::|      :||..|  .|..|.:|.:        
Human   397 AIRPRCVEL--RHLCDDFINGNKK------KWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVD 453

  Fly   530 -CD---------DDGCSYL------------------DEGLSVDIKSK---------NVQSL--- 554
             |.         :|..::|                  :..|::|.|:|         :||.:   
Human   454 KCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHK 518

  Fly   555 ---------------------HESGTDEKLSRKT------ILLARTEDTNDV--------TQGIS 584
                                 |...:.:.:|.||      :.|||...|::.        ::|..
Human   519 RQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKE 583

  Fly   585 DGTTYFTGSLNITHLPKSNEIFKKPQD---PEMQRHR-------RGHILKELFETEKIYVNEIAS 639
            |..|.|.        .||.|||:...:   ||:::..       |..|:::|.|||:||:.||.|
Human   584 DDETKFE--------VKSEEIFESHHERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKS 640

  Fly   640 ILKGY---YDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKR 701
            |:.||   .|.:......|..||...:.||||:.|:|.|||..|||:||.|....|.:|.||:||
Human   641 IIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKR 705

  Fly   702 RDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKD 766
            ::.. |:|..|.:|:.|:..:.:...|. .:|..||..|.|.|||..||..|.||:.|||:|||.
Human   706 KEDL-QIYFKYHKNLPRARAIWQECQDC-AYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKG 768

  Fly   767 LLLF-----------------------TDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSG 808
            ||.|                       |.:.:...||:.||..:..::|....::...::|....
Human   769 LLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPD 833

  Fly   809 DLAKQGELLMQDSFQVWIESK-----KDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSS--Y 866
            |:.|.|:||:...|.||...|     ||: :|.||.:|.|:|:::.::.||...:.|....|  |
Human   834 DIGKLGKLLLHGPFSVWTIHKDRYKMKDL-IRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHY 897

  Fly   867 QFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKG 931
            .||..:|:..:.:.:...|..::||:..:...|.|.|||::..:::.|.:||.::|..|...:|.
Human   898 SFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962

  Fly   932 DQIARYNI-------RHQSLWQK------SSCEAP-----NITHCSLRR---TECFELPLNDSNR 975
            ....::.:       .....|.|      :|.|.|     .|..||.|.   .:.||    |...
Human   963 QGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFE----DCEG 1023

  Fly   976 NTNIRSEKTCLSDQNIVNGPSVQDQHEKNSWSS-----------DCSDIDEDET 1018
            ..::..|.:.||...:...   .|.||..|..|           :..:.||:||
Human  1024 AEDMEKESSALSLAGLFQS---DDSHETCSSKSAFLERGESSQGEKEERDEEET 1074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30440NP_610172.1 RhoGEF 622..796 CDD:214619 72/199 (36%)
PH-like 802..925 CDD:302622 38/129 (29%)
PH 829..922 CDD:278594 28/99 (28%)
MCF2L2NP_055893.4 SEC14 52..190 CDD:214706
SPEC 321..523 CDD:238103 35/224 (16%)
Spectrin 323..428 20/127 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..614 19/91 (21%)
RhoGEF 623..820 CDD:214619 72/198 (36%)
PH-like 827..956 CDD:418428 38/129 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..1114 24/120 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001442
OrthoInspector 1 1.000 - - otm40749
orthoMCL 1 0.900 - - OOG6_102562
Panther 1 1.100 - - O PTHR22826
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X905
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.870

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