Protein Alignment CG30440 and MCF2L2

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_055893.4
• Gene: MCF2L2 / 23101
• HGNCID: 30319
• Length: 1114
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 216/899 - (24%)
• Similarity: 350/899 - (38%)
• Gaps: 266/899 - (29%)

  Fly   328 LSKE----SERQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKC-----NID-------L 376
            ||.|    |..:.||.     ||:.||  |:......||....:...||     |::       :
Human   234 LSTEDLLMSHTRQRDK-----LQDELK--LLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTM 291

  Fly   377 ERKLNDLNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCKFIRSYNRD-CETIFP----------- 429
            ||.|..|:..|:      :.:.:.::.:|    |:|.|..::.:..| |:....
Human   292 ERLLVQLDETEK------AFSHFWSEHHL----KLNQCLQLQHFEHDFCKAKLALDNLLEEQAEF 346

  Fly   430 TG-------------DHSDLNEFRKSFMP-QSVDLLSSASVSLSSCDGSCLNKDSICGSEEDCCE 480
            ||             :|..|.|  ||..| :...||:             |..|.:..|.....:
Human   347 TGIGDSVMHVEQILKEHKKLEE--KSQEPLEKAQLLA-------------LVGDQLIQSHHYAAD 396

  Fly   481 CNEYQCIATPPNELSKDCLNAVEEGVFCNTEYD------DFHENL--TSSCCCSGSF-------- 529
            ....:|:..  ..|..|.:|..::      ::|      :||..|  .|..|.:|.:
Human   397 AIRPRCVEL--RHLCDDFINGNKK------KWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVD 453

  Fly   530 -CD---------DDGCSYL------------------DEGLSVDIKSK---------NVQSL--- 554
             |.         :|..::|                  :..|::|.|:|         :||.:
Human   454 KCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHK 518

  Fly   555 ---------------------HESGTDEKLSRKT------ILLARTEDTNDV--------TQGIS 584
                                 |...:.:.:|.||      :.|||...|::.        ::|..
Human   519 RQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKE 583

  Fly   585 DGTTYFTGSLNITHLPKSNEIFKKPQD---PEMQRHR-------RGHILKELFETEKIYVNEIAS 639
            |..|.|.        .||.|||:...:   ||:::..       |..|:::|.|||:||:.||.|
Human   584 DDETKFE--------VKSEEIFESHHERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKS 640

  Fly   640 ILKGY---YDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKR 701
            |:.||   .|.:......|..||...:.||||:.|:|.|||..|||:||.|....|.:|.||:||
Human   641 IIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKR 705

  Fly   702 RDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKD 766
            ::.. |:|..|.:|:.|:..:.:...|. .:|..||..|.|.|||..||..|.||:.|||:|||.
Human   706 KEDL-QIYFKYHKNLPRARAIWQECQDC-AYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKG 768

  Fly   767 LLLF-----------------------TDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSG 808
            ||.|                       |.:.:...||:.||..:..::|....::...::|....
Human   769 LLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPD 833

  Fly   809 DLAKQGELLMQDSFQVWIESK-----KDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSS--Y 866
            |:.|.|:||:...|.||...|     ||: :|.||.:|.|:|:::.::.||...:.|....|  |
Human   834 DIGKLGKLLLHGPFSVWTIHKDRYKMKDL-IRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHY 897

  Fly   867 QFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKG 931
            .||..:|:..:.:.:...|..::||:..:...|.|.|||::..:::.|.:||.::|..|...:|.
Human   898 SFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962

  Fly   932 DQIARYNI-------RHQSLWQK------SSCEAP-----NITHCSLRR---TECFELPLNDSNR 975
            ....::.:       .....|.|      :|.|.|     .|..||.|.   .:.||    |...
Human   963 QGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFE----DCEG 1023

  Fly   976 NTNIRSEKTCLSDQNIVNGPSVQDQHEKNSWSS-----------DCSDIDEDET 1018
            ..::..|.:.||...:...   .|.||..|..|           :..:.||:||
Human  1024 AEDMEKESSALSLAGLFQS---DDSHETCSSKSAFLERGESSQGEKEERDEEET 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	72/199 (36%)
		PH-like	802..925	CDD:473070	38/129 (29%)
MCF2L2	NP_055893.4	SEC14	52..190	CDD:214706
		SPEC	321..523	CDD:238103	35/224 (16%)
		Spectrin	323..428		20/127 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..614		19/91 (21%)
		RhoGEF	623..820	CDD:214619	72/198 (36%)
		PH-like	827..956	CDD:473070	38/129 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..1114		24/120 (20%)