Protein Alignment CG30440 and Vav2

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_006497917.1
• Gene: Vav2 / 22325
• MGIID: 102718
• Length: 878
• Species: Mus musculus
• Alignment Length: 662
• Identity: 133/662 - (20%)
• Similarity: 254/662 - (38%)
• Gaps: 193/662 - (29%)

  Fly   375 DLERKLND-LNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCKFIRSYNRDC--------ETIFPT 430
            ||.:.|.| :.:.:..|..:......|:..:...||:....|.||::.:.|        ..:|..
Mouse    32 DLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDP 96

  Fly   431 GDHSDLNEFRKSFMPQSVDLLSSASVSLSS------CDGSCLNKDSICGSEEDCCECNEYQCIAT 489
            .|..|:.:|.|  :..:|..||..|::.|.      .:.:..|.|.:..|.|:..:
Mouse    97 FDLFDVRDFGK--VISAVSRLSLHSIAQSKGIRPFPSEETAENDDDVYRSLEELAD--------- 150

  Fly   490 PPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSL 554
             .::|.:|..:.|.    |..|.||.:|::                      :.|:::...::.:
Mouse   151 -EHDLGEDIYDCVP----CEDEGDDIYEDI----------------------IKVEVQQPMIRYM 188

  Fly   555 HESGTDEKLSRKTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRR 619
            .:.|             .|||                                         .:|
Mouse   189 QKMG-------------MTED-----------------------------------------DKR 199

  Fly   620 GHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDL 684
            ...|.|:.|||..|...:..|.|.|...|:...| ||.:.    .:|.||.::...|:. ||:.:
Mouse   200 SCCLLEIQETEAKYYRTLEDIEKNYMGPLRLVLS-PADMA----AVFINLEDLIKVHHS-FLRAI 258

  Fly   685 E-NCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFK----ECQIGL-GHK 743
            : :.::....:|..|::.:::.. :|..||.:::.::.....|:.:...|:    ||.:.: ..|
Mouse   259 DVSMMAGGSTLAKVFLEFKERLL-IYGEYCSHMEHAQSTLNQLLASREDFRQKVEECTLRVQDGK 322

  Fly   744 LPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVND-----------S 797
            ..|...|:.|:||:.||.||||:||..:.:...|.:||.||:.|..:...:|:           |
Mouse   323 FKLQDLLVVPMQRVLKYHLLLKELLSHSADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKIS 387

  Fly   798 MHQISITGFSGDLAK------QGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQT 856
            ..|.||......|.:      .|||.::   .:...:|:|         |::||:.|.:::||
Mouse   388 EFQCSIENLQVKLEEFGRPKIDGELKVR---SIVNHTKQD---------RYLFLFDKVVIVCK-- 438

  Fly   857 SKSGYNKSSYQFKSDVKMSQIGLTESV--SGDAKRF--EVW--------LKGRQEVYTLQASTIG 909
             :.||   ||:.|..:::....:|:..  :.|.|:.  ::|        |:|:|. :.....|..
Mouse   439 -RKGY---SYELKEVIELLFHKMTDDPMHNKDIKKSHGKMWSYGFYLIHLQGKQG-FQFFCKTED 498

  Fly   910 VKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLW-----QKSSCEAPNI------------TH 957
            :|..|:.:.:..:.|    :|.|   :.|..|.|..     :.::|:|..:            |.
Mouse   499 MKRKWMEQFEMAMSN----IKPD---KANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTR 556

  Fly   958 CSL-RRTECFEL 968
            |.: ...||.|:
Mouse   557 CGVGAHKECLEV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	48/179 (27%)
		PH-like	802..925	CDD:473070	29/140 (21%)
Vav2	XP_006497917.1	CH_VAV2	2..120	CDD:409112	20/89 (22%)
		RhoGEF	202..374	CDD:459876	48/178 (27%)
		PH_Vav	389..516	CDD:269930	31/149 (21%)
		C1_VAV2	519..576	CDD:410418	10/50 (20%)
		SH3_VAV2_1	590..649	CDD:212913
		SH2_Vav2	667..769	CDD:198269
		SH3_VAV2_2	819..876	CDD:212910