Protein Alignment CG30440 and Vav1

DIOPT Version :9

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: NP_035821.3
• Gene: Vav1 / 22324
• MGIID: 98923
• Length: 845
• Species: Mus musculus
• Alignment Length: 600
• Identity: 128/600 - (21%)
• Similarity: 234/600 - (39%)
• Gaps: 155/600 - (25%)

  Fly   480 ECNEY--QCIATPPN-----ELSKDC--LNAVEEGV-FC-----------NTEYDDFHENLTSSC 523
            :|..:  ||...||:     |.::.|  ..|:.:|| .|           |....:....::...
Mouse     6 QCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPQAINLREVNLRPQMSQFL 70

  Fly   524 CCS------GSFCDDDGC--SYLDEGLSV-DIK--SKNVQSLHESGTDEKLSRKTILLARTEDT- 576
            |..      .:.|:..|.  |.|.|...: |::  .|.:.:|...........|.|:...|||:
Mouse    71 CLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMPFPTEDSA 135

  Fly   577 ---NDVTQGISDGTTYFTGSLNIT-------------HLPKSNEIFKK-------PQDPEMQRH- 617
               .|:..|:||       .::.|             ...:.:||::.       |..|:|..:
Mouse   136 LNDEDIYSGLSD-------QIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRLESVPTPPKMTEYD 193

  Fly   618 RRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLK 682
            :|...|:|:.:||:.|.:.:.||.:.:...|:. ...|..::    .:|.|:.|::|.|.. |||
Mouse   194 KRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQR-FLKPQDME----TIFVNIEELFSVHTH-FLK 252

  Fly   683 DLENCISVTERVAL--CFVKRRDKFYQLYSFYCQNIQRSEKLRETLV----DTHMFFKEC-QIGL 740
            :|::.::......|  .|:|.:::|. :|..||..::.:.|..:.:.    |..|..:|| |...
Mouse   253 ELKDALAGPGATTLYQVFIKYKERFL-VYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRAN 316

  Fly   741 GHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVND--------- 796
            ..:..|...|:.|:||:.||.|||::|:..|.:.:.:..|:.|||.|..:.:|||:
Mouse   317 NGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLR 381

  Fly   797 --SMHQISITGFSGDLAKQGELLMQDSFQVW-IE--SKKDIRLRMKPKRRHIFLYQKSLLLCKQT 856
              :..|:||......||..|...:....::. :|  ||.|         |:.||..|:||:||:.
Mouse   382 QITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTD---------RYAFLLDKALLICKRR 437

  Fly   857 SKSGYNKSSYQFKSDVKMSQIGLTESVSGD-----------------AKRFEVWLKGRQEVYTLQ 904
            .      .||..|:.|.:....:.:..||:                 |:.:|::.|.|:
Mouse   438 G------DSYDLKASVNLHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRE------ 490

  Fly   905 ASTIGVKEMWVAEIKRVL-------------------FNQLEKLKGDQIARYNIRHQSLWQKSSC 950
                 :|:.|:.:.:..:                   |.:....|..|:......:|. ::...|
Mouse   491 -----LKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQG-YRCYRC 549

  Fly   951 EAPNITHCSLRRTEC 965
            .||....|..|...|
Mouse   550 RAPAHKECLGRVPPC 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	50/180 (28%)
		PH-like	802..925	CDD:302622	30/161 (19%)
		PH	829..922	CDD:278594	22/109 (20%)
Vav1	NP_035821.3	CH	18..102	CDD:320720	15/83 (18%)
		RhoGEF	195..371	CDD:238091	50/182 (27%)
		PH_Vav	385..508	CDD:269930	30/148 (20%)
		C1_1	516..567	CDD:278556	9/49 (18%)
		SH3_VAV1_1	596..658	CDD:212912
		SH2_Vav1	665..767	CDD:198268
		SH3_VAV1_2	786..839	CDD:212909

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910