DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG30440 and cgef-1

DIOPT Version :9

Sequence 1:NP_610172.1 Gene:CG30440 / 35496 FlyBaseID:FBgn0050440 Length:1057 Species:Drosophila melanogaster
Sequence 2:NP_741736.2 Gene:cgef-1 / 180571 WormBaseID:WBGene00006496 Length:1055 Species:Caenorhabditis elegans


Alignment Length:1106 Identity:242/1106 - (21%)
Similarity:405/1106 - (36%) Gaps:308/1106 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 TSRSLCPDTAKTEPKVYSL-----------RFVLNKSED-KDYMSRLK---AQNDFSQSSCLCNN 130
            ||..:...|....|...|:           .|..:...| ||..:.||   ..||....|.: ..
 Worm    15 TSEEVTTSTLSRGPMTMSVSKSNSQFIEAPAFFYDMDTDLKDLKTALKDVDLLNDSGYRSVM-ER 78

  Fly   131 LSHANTEAGAYQNDGILKGQRDHSD-----FLTAAGG-IQSR------ADRIARIETCGIRTTH- 182
            .:|....:..:..|.....:.|.:|     :||..|. |:.|      |.|.|.|.  |.|||. 
 Worm    79 STHPFATSLVFHEDNGFDSEDDATDEHWDGYLTVGGDRIKIRDMSDILATRYAFIS--GARTTEG 141

  Fly   183 --------------LQPETQILK-----PVTEPNETRF----DQHSPDWLFKNSRIGDVSNSSKL 224
                          .:..:.::|     |..|.:...|    |:.|..|....:.:..:|:....
 Worm   142 LTIVTFPDSRSTLPFEDYSLLVKYLLQVPPLEDSHKGFVIIIDRRSDKWSSVRTLLLQISSFFPG 206

  Fly   225 SAC-NSELPPEEYKGRTL---YHDTKFDCAYIKNRRPLITTESKMSITEAEHPQTKYTDIKYDYK 285
            ..| ...:.||....|.|   |......|::     .:|..||...:       .||  |.:::.
 Worm   207 KICVTFVIKPEGVLQRALEVGYRGAADTCSF-----QVIQLESSAEL-------RKY--IHHEFL 257

  Fly   286 TCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYE------NIQKLHLS--------KESERQI 336
            |..:. ||                     :.|::.|      :|:::..|        .|..:.:
 Worm   258 TMDVG-GL---------------------IKYNHLEWVQHRMDIERMKASATAIAASLTEFGKTL 300

  Fly   337 RDNGDPNDLQNFLKKNLIKATTNE-----------------LLKAAAQSTKKCNID--------- 375
            |:...|||..:..:  :::..|.|                 |||:..|..||...:         
 Worm   301 RETELPNDADSTAR--ILELQTAEKMAIKEEFKIAVRKGFTLLKSVRQLDKKPTPEQLSPTRLHN 363

  Fly   376 ---LERKLNDLNIKEEDHTSNDS------------------GNSY--------KNDPYLVSMSKI 411
               :||.|..|   ||...|.||                  .:|:        ::..||....::
 Worm   364 VTAIERMLVQL---EETERSFDSFWTKHERRLRYCLELRQFEDSFRKLQAAFARHMLYLEEHREV 425

  Fly   412 NSCKFIRSYNRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKDSICGSEE 476
            .:|.....:..:....:..|...:: |..::......||::|             |:..:.||.|
 Worm   426 GNCTEKALHLAEQHRQYAEGAMEEV-EASRNLKKAGEDLINS-------------NEAELSGSLE 476

  Fly   477 DCCECNEYQCIA-TPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSGSFCDDDGCSYLDE 540
            ..||..|....| |...|...|||.          .....||.:..    :.|:| ..|...|..
 Worm   477 PKCEELERMAAALTSALERRGDCLK----------RSATMHEQIAK----ANSWC-TRGADLLTN 526

  Fly   541 GLSVDIKSKN-------VQSLHESGTD---EKLSRKT-----ILLARTEDTNDVTQGISDGTTYF 590
            |:: |..:.|       :.:..|.||:   |.|...|     :||..|.:|:.:...|.:.    
 Worm   527 GMT-DFTNPNPSSSLTTLDAFIEEGTNLNIEFLKDTTSPMNQLLLLTTIETSTLLNLIEER---- 586

  Fly   591 TGSLNITHLPKSNEIFK----KPQ--------------------------------------DPE 613
            .|.:....|.|.:::.|    ||.                                      .|.
 Worm   587 IGDIRRMSLAKRDQLTKLHLQKPPPVQVVTPEKKSKKNSSKNELDSKDVPSCSGESTPAGTLSPR 651

  Fly   614 MQRHRRGHILKELFETEKIYVNEIASILKGY---YDRLKSDESAPASLQGKANVLFGNLNEIYSF 675
            .:.....:...|:..||..||.::..|:..|   ::..::..|.|.:|:||.:.||||:.|:|.|
 Worm   652 RETREVTNAFDEMIATEISYVADLKDIIIHYLEPFEATENQNSLPDTLRGKPDCLFGNVRELYKF 716

  Fly   676 HNDVFLKDLENCISVTERVALC--FVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQI 738
            |:...|:||....|..|   :|  .::.|::.|..|..|||....::|:|:: |..|.||||||.
 Worm   717 HHRTVLEDLVAARSTAE---MCRVLMQHRNQIYVTYRTYCQIHGSNQKVRDS-VKNHPFFKECQR 777

  Fly   739 GLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSC----RNELKNALDCMLIVLKCVNDSMH 799
            ...|.:.:.:|||||:|||.||||||.:::     |.|    |:|:....|.|:.:|..::.||.
 Worm   778 NANHNMDMSSYLLKPIQRIMKYQLLLGNIM-----DDCPADVRDEVAMTRDSMVELLNQIDASMQ 837

  Fly   800 QISITGFSGDLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLC-KQTSKSGYNK 863
            |:.|:|::|||...|.|.:|....|:..::|......:.::|.||.:..:::.| |:.|..|...
 Worm   838 QLHISGYNGDLKSLGLLRLQTECDVFTYNRKKKAKLSRAQKRFIFFFDGAVMFCKKRVSNPGTTL 902

  Fly   864 SS----YQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFN 924
            :|    ::.|..:.:..:|...|....|.|||||...:.:.|.::......:..|:        .
 Worm   903 NSEPEYFEHKFCIPIISLGYDTSSRTGASRFEVWDDAKTDAYVIETIDQTARTKWI--------Q 959

  Fly   925 QLEKLKGDQIA-RYNIRHQSLW-----QKSSCEAPNITHCSLRRTECFELPLNDSNRNTNIRSEK 983
            :|.|.:..|.| ..|.:....|     .:|||.:      |.|.::.     .||..:||..::.
 Worm   960 RLGKSETAQDACLENRQRPKSWASTVSNESSCSS------STRESDS-----TDSTMDTNGNTQT 1013

  Fly   984 T 984
            |
 Worm  1014 T 1014

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30440NP_610172.1 RhoGEF 622..796 CDD:214619 64/182 (35%)
PH-like 802..925 CDD:302622 29/127 (23%)
PH 829..922 CDD:278594 20/97 (21%)
cgef-1NP_741736.2 CRAL_TRIO_2 141..269 CDD:372686 25/163 (15%)
RhoGEF 658..833 CDD:238091 64/183 (35%)
PH-like 841..968 CDD:388408 31/134 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166481
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001442
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102562
Panther 1 1.100 - - LDO PTHR22826
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3352
SonicParanoid 1 1.000 - - X905
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.870

Return to query results.
Submit another query.