DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and Mcf2l

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	NP_001357978.1	Gene:	Mcf2l / 17207	MGIID:	103263	Length:	1178	Species:	Mus musculus

Alignment Length:	1078	Identity:	296/1078 - (27%)
Similarity:	443/1078 - (41%)	Gaps:	284/1078 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IQSRADRIARIETCGIRTTHLQPETQILKPVTEPNETRFDQHS-PDWLFKNSR--------IGDV 218
            |..|.|:...::...:|.....|....|..|..|  |.|.|.: .|..||.:|        :..:
Mouse   105 IDRRQDKWTSVKASVLRIAASFPANLQLVLVLRP--TGFFQRTLSDIAFKFNRDEFKMKVPVMML 167

  Fly   219 SNSSKLSACNSELPPEEYKGRTL-YHDTKFDC--AYIKNRRPLITTESKM------SITEAEHPQ 274
            |:..:|.....:....|..|.|| |..:::.|  ..|::...::...::|      .:.|.|.|.
Mouse   168 SSVPELHGYIDKSQLTEDLGGTLDYCHSRWLCHRTAIESFALMVKQTAQMLQAFGTELAETELPN 232

  Fly   275 ---------TKYTDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYEN---IQKL- 326
                     :.:|:.|...|. .:...|.:..:.|..:.........|||:.|..:|   :|:|
Mouse   233 DVQSTSLVLSAHTEKKAKVKE-DLQLALKEGNSILESLREPLAESAAHSVNQDQLDNQATVQRLL 296

  Fly   327 ----------------HLSK-ESERQIRDNGDPNDLQNFLKKNLIKATTNELLKAAAQSTKKCN- 373
                            |..| |...|:|     :..|.|.:   :|.|.:.:.:..|..|...|
Mouse   297 AQLNETEAAFDEFWAKHQQKLEQCLQLR-----HFEQGFRE---VKTTLDSMSQKIAAFTDVGNS 353

  Fly   374 -IDLERKLNDLNIKEEDHT---------SNDSGNSYKNDPYLVSMSKINSCKFIRSYNRDCETIF 428
             ..::..|.||...||..:         |.:.....:|..|.|.           |.:..||.:.
Mouse   354 LAHVQHLLKDLTAFEEKSSVAVDKARALSLEGQQLIENRHYAVD-----------SIHPKCEELQ 407

  Fly   429 PTGDH--SDLNEFRKSFMPQSVDLLSSASVSLSSCD-----------GSCLNKDSI--------- 471
            ...||  |::.. |:..:.:|::|.|....|:...|           ..|.::|..
Mouse   408 HLCDHFASEVTR-RRGLLSKSLELHSLLETSMKWSDEGIFLLASQPVDKCQSQDGAEAALQEIEK 471

  Fly   472 ---CGSEEDCCECN----EYQCIATPPNELSKDCLNAVEEGVFCNTEYDD--FH----------- 516
               .|:|....|.|    ||:||      |::|.|..|:: ||...|..:  ||
Mouse   472 FLETGAENKIQELNEIYKEYECI------LNQDLLEHVQK-VFQKQESTEEMFHRRQASLKKLAA 529

  Fly   517 -------------ENLTSSCCCS-GSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKT 567
                         |.||.|...| ||:...:..|  .||                   ..|.|..
Mouse   530 KQTRPVQPVAPRPEALTKSPSPSPGSWRSSENSS--SEG-------------------NALRRGP 573

  Fly   568 ILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQRHRRGHILKELFETEKI 632
            ...|::|.:..     ..|.|..||                 ::.|.....|.|::.||.:||:.
Mouse   574 YRRAKSEMSEP-----RQGRTSSTG-----------------EEEESLAILRRHVMNELLDTERA 616

  Fly   633 YVNEIASILKGYYDRLKSDESA---PASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERV 694
            ||.|:..:|:||...:.:...|   ...||.|.|:||||:.|||.|||.:||::||:||...|.|
Mouse   617 YVEELLCVLEGYAAEMDNPLMAHLISTGLQNKKNILFGNMEEIYHFHNRIFLRELESCIDCPELV 681

  Fly   695 ALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITK 759
            ..||::|.::| |:|..||||..|||.|.....|. .||:|||..|.|||.|.:|||||||||||
Mouse   682 GRCFLERMEEF-QIYEKYCQNKPRSESLWRQCSDC-PFFQECQKKLDHKLSLDSYLLKPVQRITK 744

  Fly   760 YQLLLKDLLLFTDNDSCRNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQV 824
            ||||||::|.::.:.....:|:.||..:|.:||.||||||.|:|||:.|:|...|:||||.||.|
Mouse   745 YQLLLKEMLKYSKHCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSV 809

  Fly   825 WIESKKDIR-----LRMKPKRRHIFLYQKSLLLCKQTSKS--GYNKS-SYQFKSDVKMSQIGLTE 881
            |.:.||...     .|.||.:||:||::|::|.||:..::  ||.|: ||.:|..:.|:.:|:||
Mouse   810 WTDHKKGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMTAVGITE 874

  Fly   882 SVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRVLFNQLEKLKGDQIARYNIRHQSLWQ 946
            :|.||.|:||:|...|:|||.:||.|..:|..||.||::||.:||      |..|...:|::|.|
Mouse   875 NVKGDTKKFEIWYNAREEVYIIQAPTPEIKAAWVNEIRKVLTSQL------QACREASQHRALEQ 933

  Fly   947 KSSCEAP-------------NITHCSLRRTECFEL--------------------PLNDSNRNTN 978
            ..|...|             |:.....|:|:...|                    |.:.|..:..
Mouse   934 SHSLPLPTPSSTSPTKGNTRNVKKLEDRKTDPLSLEGYVSSSLPKPPEKGKDDAVPSSTSESSAL 998

  Fly   979 IRSEKTCLSDQNIVNGPSVQD----QHEKNS-------------------------WSS-----D 1009
            .|...|.....|:...|:..|    :||..|                         |||     :
Mouse   999 SRKRFTLQGLANLKASPTSPDKKAKRHEVKSDPTPFGLRGWSKTSHSLEAPEEDGGWSSAEELIN 1063

  Fly  1010 CSDIDEDETINP----------ILMQKTGQPKLLWNRS 1037
            .||.:||..:.|          ::..:.|.|..|..||
Mouse  1064 SSDAEEDGGVGPKKLVPGKYTVVMDDEKGGPDTLAMRS 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	83/176 (47%)
		PH-like	802..925	CDD:302622	58/130 (45%)
		PH	829..922	CDD:278594	42/100 (42%)
Mcf2l	NP_001357978.1	SEC14	46..191	CDD:214706	20/87 (23%)
		SPEC	322..524	CDD:238103	49/228 (21%)
		RhoGEF	603..780	CDD:238091	84/178 (47%)
		PH_Dbs	787..918	CDD:269934	58/130 (45%)
		SH3_DBS	1082..1136	CDD:212791	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001442
OrthoInspector	1	1.000	-	-		otm42821
orthoMCL	1	0.900	-	-		OOG6_102562
Panther	1	1.100	-	-	O	PTHR22826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X905
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.870