DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30440 and PLEKHG4B

DIOPT Version :9

Sequence 1:	NP_610172.1	Gene:	CG30440 / 35496	FlyBaseID:	FBgn0050440	Length:	1057	Species:	Drosophila melanogaster
Sequence 2:	NP_443141.4	Gene:	PLEKHG4B / 153478	HGNCID:	29399	Length:	1627	Species:	Homo sapiens

Alignment Length:	1256	Identity:	267/1256 - (21%)
Similarity:	449/1256 - (35%)	Gaps:	373/1256 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKMQIHPTKMEEDSDTRN-STYVPK------MELLMTHYI-------HEGKKAIMYR------SS 48
            |..|.||.:......|.: .:.|||      .|||.:..:       ..|:..:..|      :.
Human   520 PARQPHPEQEGWPPGTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTR 584

  Fly    49 EPQIAARRNKKTRFVGN--RRQLRNLS--------QPENSHKTSRSLCPDTAKTEPKVYSLRFVL 103
            |....|...:...:..:  |:::|:|.        :...:...|::|......|.|.::|:..::
Human   585 EHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLV 649

  Fly   104 NKSE----DKD------YMSRLKAQNDFSQSSCLCNNLSHANTEAGAYQNDGILKGQRDHSDFLT 158
            :|..    |||      .:|.|||.:.|..|..|..:|            ||..  ...|.|::.
Human   650 DKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADL------------DGSF--PYSHGDWIC 700

  Fly   159 AAGGIQSRADRIA----------RIETCGIRTTHLQPET-QILKPVTEPNETRFDQHSPDWLFKN 212
                .:.|.:..|          :...|.: .||..|.| |.:..:.:.:||.......|.|..:
Human   701 ----FRQRLEHFAANCEEAIIFLQNSFCSL-NTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVS 760

  Fly   213 SRIGDVSNSSKLSACNSELPPEEYKGRTLYHDTKFDCAYIKNRRPLITTESKMSITEAEHPQTKY 277
            .|:...:..::|.  ..||..|:.:.......:.:|....:..|.::|:.:::.  :.||.:
Human   761 LRLEGGTVLARLR--REELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQ--QLEHLR--- 818

  Fly   278 TDIKYDYKTCSISQGLHQNKAFLNKVPPSKQSKPFHSVDYDYYENIQK-LHLSKESERQIRDNGD 341
                   :..|:.:|..|                         ::.|| |.|:||:.::..:.
Human   819 -------ELASLLEGNDQ-------------------------QSCQKGLQLAKENPQRTEEM-- 849

  Fly   342 PNDLQNFLKKNLIKATTNELLKAAAQSTKKCNI-DLERKLNDLNIKEEDHTSNDSGNSYKN--DP 403
               :|:| ::.|          :|..|..:|.. :|.|......:.|       :.:|:..  ||
Human   850 ---VQDF-RRGL----------SAVVSQAECREGELARWTRSSELCE-------TVSSWMGPLDP 893

  Fly   404 YLVSMSKINSCKFIRSYNRDCETIF-------------------PTGDHSDL------------- 436
            .....|.:..|  :||.:::..::.                   |.....||
Human   894 EACPSSPVAEC--LRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE 956

  Fly   437 -------------------------NEFRKSFMPQSVDLLSSA------SVSLSSCDGSCLNKDS 470
                                     ...|:...|.|.....|.      :..||...|..|
Human   957 ALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRAL---- 1017

  Fly   471 ICGSEEDCCECNEYQCIATPPNELSKDCLNAVEEGVFCNTEYDDFHENLTSSCCCSG-------- 527
            :||.:.:.....  .|....|..|.:..     .|....|.:      |..|..||.
Human  1018 LCGQDGETLRPG--LCALWDPLSLLRGL-----PGAGATTAH------LEDSSACSSEPTQTLAS 1069

  Fly   528 ---------------SF------------CDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSR 565
                           ||            |..|..|...:||.|              |....:.
Human  1070 RPRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEV--------------TSTVATE 1120

  Fly   566 KTILLARTEDTNDVTQGISDGTTYFTGSLNITHLPKSNEIFKKPQDPEMQ--RHRRGHILKELFE 628
            |.:.|.:...:..|||..|              |...:.:....:|...|  ..|..||:.|:..
Human  1121 KKLPLWQHARSPPVTQSRS--------------LSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIA 1171

  Fly   629 TEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTER 693
            ||:.|:..:..::..|:..::..: .|..|:||.:|:||||.:::.||...||::||.|......
Human  1172 TEREYIRCLGYVIDNYFPEMERMD-LPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLA 1235

  Fly   694 VALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTH--MFFKECQIGLGHKLPLGAYLLKPVQR 756
            |...|::..::| .:|..|.:|..:|    :.|:.:|  .|||:.|..||.|:.|.:|||:||||
Human  1236 VGRSFLRHEEQF-GMYVIYSKNKPQS----DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQR 1295

  Fly   757 ITKYQLLLKDLLLFTDNDSC-------RNELKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQG 814
            :.||.|||:|||   ...||       ..||:.|...:...|:..||.:...:|.|...:|.:||
Human  1296 VAKYALLLQDLL---KEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQG 1357

  Fly   815 ELLMQDSFQVWIESKKDIRLRMKPKRRHIFLYQKSLLLCKQTSKSGYNKSSYQFKSDVKMSQIGL 879
            :|..:|.|.|....||.:        ||:||:: .|:|..:|.|...:...|.:|...|.::||:
Human  1358 QLRCRDEFIVCCGRKKYL--------RHVFLFE-DLILFSKTQKVEGSHDVYLYKQSFKTAEIGM 1413

  Fly   880 TESVSGDAKRFEVWLKGR---QEVYTLQASTIGVKEMWVAEIKRVLFNQLEK---LKGDQIARYN 938
            ||:|.....|||:|.:.|   |:.|.||||:..||..|...|.|:|:.|..|   |:..::|...
Human  1414 TENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMG 1478

  Fly   939 IRHQSLWQ-KSSCEAPNITHCSLRRTEC---------------------------------FELP 969
            |.:|.... |.....|:....|.|..:|                                 |:.|
Human  1479 IGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRP 1543

  Fly   970 ---LNDSNRNTNIRSEKTCLSDQNIVNGPSVQDQH------EKNSWSSD---CSDIDEDETINPI 1022
               ::||:.:::.....:.|....::  .|....|      ..:.||||   |.:.||.|   |.
Human  1544 HSTISDSSTSSSSSQSSSILGSLGLL--VSSSPAHPGLWSPAHSPWSSDIRACVEEDEPE---PE 1603

  Fly  1023 LMQKT------GQPKLLWNRS 1037
            |...|      |.|.:|.:|:
Human  1604 LETGTQAAVCEGAPAVLLSRT 1624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	60/182 (33%)
		PH-like	802..925	CDD:302622	44/125 (35%)
		PH	829..922	CDD:278594	34/95 (36%)
PLEKHG4B	NP_443141.4	Herpes_ICP4_C	186..>468	CDD:332854
		RhoGEF	1165..1308	CDD:306973	54/151 (36%)
		PH_puratrophin-1	1332..1467	CDD:270062	49/143 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810