Protein Alignment CG30440 and trio

DIOPT Version :10

• Sequence 1: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Sequence 2: XP_061507587.1
• Gene: trio / 1276778
• VectorBaseID: AGAMI1_007407
• Length: 2372
• Species: Anopheles gambiae
• Alignment Length: 1290
• Identity: 282/1290 - (21%)
• Similarity: 470/1290 - (36%)
• Gaps: 393/1290 - (30%)

  Fly     1 MSAPKMQIHPTKMEEDSDTRNSTYVPKMELLMTHY------------------------IHEGK- 40
            :||.:.|:|.....|:|          :||...|.                        |.:|:
Mosquito   652 ISAWQEQLHAEVTNEES----------LELANEHLEGTERMLEQCKEQEENTLKTCMQAIAQGEA 706

  Fly    41 -----KAIMYRSSEPQIAARRNKKTRFVGNRRQLRNLSQPENSHKTSRSLCPDTAKTEPKVYSLR 100
                 :||....|...:.|.:|...|...||..|..|.|              |.:.:..:| ||
Mosquito   707 LLQELRAIEEEDSSGSLTAVQNALDRIQKNRLDLEGLWQ--------------TRRMKIDLY-LR 756

  Fly   101 FVLNKSEDKDYMSRL----------KAQNDFSQSS--CLCNNLSHANTEAGAYQ--NDGILKGQR 151
            ..:.:.:..:..|:|          :...||.::.  ...:|.|....:...||  |.|....|
Mosquito   757 LRIFERDALEVSSQLEMWSEELQHTEVSRDFQKTEQFLRLHNESVNQMQTTTYQVMNQGHELMQ- 820

  Fly   152 DHSDFLTAAGGIQSRADRIARIET---CGIRTTHLQPETQI-LKPVTEPNETRFDQHSPDWLFKN 212
                 |..:.|:...||.....:|   |.:...|   :.:: |:.:.|....:.:|......|:|
Mosquito   821 -----LFESSGLLIMADANHTAQTRVQCLLEFLH---DRELDLEDMAEAKRIKLEQSMQLCHFQN 877

  Fly   213 SR---IGDVSNSSKLSACNSELPPE----------------------------EYKGRTLYHDTK 246
            ..   |..:.|...:...|..:|..                            :|:...|.:...
Mosquito   878 DANQVISWIRNGEAMLMANFSIPNNFQEAEQLRKEHEQFQVAIERTHTSAVQVKYRADALMNANH 942

  Fly   247 FDCAYIKNRRPLITTESKMSITEAEHPQTKYTDIKYDYKT----CSISQGLHQNKAFLNKVPPSK 307
            :|...||:....:|.:.:..:|.||......|..:..:||    ||:...|.:...
Mosquito   943 YDPQSIKDIAEDVTKKWQKLVTCAEERHKLVTASQNFFKTAEQVCSVLDSLEKEYR--------- 998

  Fly   308 QSKPFHSVDY-------DYYENIQKLHLSKESERQIRDNGDPNDLQNFLKK-NLIKATTNELLKA 364
                 ...|:       |..:.|.:| :||..|::          :.|||. .|.:.|....||.
Mosquito   999 -----REEDWCGGGGSTDKGQQIVQL-ISKHQEQK----------EAFLKACTLARRTAETFLKY 1047

  Fly   365 AAQS-----TKKCNIDLERKLNDLNIKEEDHTSNDSGNSYKNDPYLVSMSKINSCK----FIRSY 420
            |.:|     .|...::.|.::.  :|.|:..........|    :.....:::.|:    |.||.
Mosquito  1048 ANRSLQFYHVKPTTVNSESRVK--SILEKLLAQETQVLEY----WTQRKKRLDQCQQFVLFERSA 1106

  Fly   421 NRDCETIFPTGDHSDLNEFRKSFMPQSVDLLSSASVSLSSCDGSCLNKDSICGSEED----CCEC 481
            .:..|.|..||:                       ..|||      .|:.:|.|.|:    ..|.
Mosquito  1107 KQAIEWIHDTGE-----------------------AYLSS------RKNKLCSSREESELLLREH 1142

  Fly   482 NEYQCIATPPNELSK------DCLNAVEEG-----------VFCNTEYDDFHE-------NLTSS 522
            ||::..|....|..|      |.|  ||:|           ...:..|.||.:       ||..|
Mosquito  1143 NEFKSTAKETRERVKLLIQLADTL--VEKGHAHASSIKQWVATVDYRYKDFSQRMEIYRSNLEKS 1205

  Fly   523 CCCSGSFCDDDGCSYLDEGLSVDIKSKNVQSLHESGTDEKLSRKTILLARTEDTNDVTQGISDG- 586
            .                 ||...|:.::..:|..|.:....|..::...|:..:.:.:.|||.|
Mosquito  1206 L-----------------GLPGIIQQQDDNNLSSSNSSNNSSNSSLNAGRSLSSANSSSGISSGS 1253

  Fly   587 ------------------------------------TTYFTGS---------LNITHLPKSNE-- 604
                                                :|..||:         |...|...|.|
Mosquito  1254 GSYASVIAVGGASPVPAGGVTGGSNGDGSSSSSGPCSTSSTGTSAGSAGGSVLEYRHSDPSLETK 1318

  Fly   605 ------------IFKKPQDPEMQR--HRRGHILKELFETEKIYVNEIASILKGYYDRLKSDESAP 655
                        ..:|..:.|.::  .::..|:.||.:||:.||.::.:.:..:...|||.:..|
Mosquito  1319 LNAAAAGAGAVGAVQKEINEEKRKSARKKEFIMAELLQTERTYVKDLETCISVFLRELKSGQQVP 1383

  Fly   656 ASLQGKANVLFGNLNEIYSFHNDVFLKDLENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSE 720
            .:|.|:.::||.|:.:||.||..:||::||...::.|.|..|||....|| .:|..||||  :.:
Mosquito  1384 PNLVGREHILFANIEDIYQFHEKIFLRELEKYETMPEDVGHCFVTWATKF-DMYVHYCQN--KPQ 1445

  Fly   721 KLRETLVDTHMFFKECQ--IGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSC----RNE 779
            .:...:.....:|.|.|  ..|.|.||  |||:||||||||||||||||      .||    |.|
Mosquito  1446 SMDYMVQHGGTYFDEVQRKHKLEHSLP--AYLIKPVQRITKYQLLLKDL------QSCCDEGRGE 1502

  Fly   780 LKNALDCMLIVLKCVNDSMHQISITGFSGDLAKQGELLMQDSFQVWIESKKDIRLRMKPKRRHIF 844
            :|:.|:.||.|.|..||.||...:......:...|::::||||.||  ..|.|.:: |.:.||:|
Mosquito  1503 IKDGLEVMLNVPKKANDVMHLSLLEQCDMPIDNLGDVVLQDSFLVW--DTKQILIK-KGRERHVF 1564

  Fly   845 LYQKSLLLCKQTSKSGYNKSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYT-----LQ 904
            |::..:|..|:. |.......|.:|:.:..|..|:||.:.||..:|.:| .||..:.:     |:
Mosquito  1565 LFELYILFSKEV-KDTNGTVKYIYKNKLLTSDFGVTEHIEGDECKFAIW-TGRAPILSDYRIVLK 1627

  Fly   905 ASTIGVKEMWVAEIKRVL---------FNQLE---KLKGDQIARYNIRHQSLWQKSSCEAPNITH 957
            |:::..|::||..::.|:         |:.|:   |:.|..:.:
Mosquito  1628 ANSLETKQLWVKRMREVMQETYFSGTSFSLLKSPAKVSGKNLGQ--------------------- 1671

  Fly   958 CSLRRTECFELPLNDSNR-----------NTNIRSEKTCLSDQNIVNGPSVQDQHEKNSWSSDCS 1011
               |.::..:..|||:::           ||. .|||..|::...|    :.| |.....:|:.|
Mosquito  1672 ---RLSKDIDDTLNDNDQDGSSLASFGSGNTT-DSEKGGLAEMTWV----IAD-HTAAPGTSELS 1727

  Fly  1012 DIDEDETINPILMQKTGQP-----KLLWNRSSSHQ----VFIKSKYILSRKTVNN 1057
             :.:.:.:..:.|..:|.|     :|..|.|.|.:    |.:......|...:||
Mosquito  1728 -VSKGQQVEIVDMNCSGAPDYCLVRLSINASDSQEGLVPVTVLKPLPSSHSKLNN 1781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	72/179 (40%)
		PH-like	802..925	CDD:473070	36/136 (26%)
trio	XP_061507587.1	None